(54 nodes) Cell communication network (Rickettsiales bacterium Ac37b)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ruvA	Holliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (201 aa)
	cheA	Chemotaxis protein CheA. (868 aa)
	AIL65654.1	Chemotaxis protein CheW. (163 aa)
	cheY_2	Chemotaxis protein CheY. (121 aa)
	cheB	Chemotaxis response regulator protein-glutamate methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (409 aa)
	AIL65619.1	Hypothetical protein. (134 aa)
	YycG_5	Sensor histidine kinase. (496 aa)
	phoR	Phosphate regulon sensor protein phoR. (452 aa)
	DivK_2	Sensor histidine kinase. (603 aa)
	AIL65482.1	ComEC family competence protein. (669 aa)
	AIL65436.1	Sensory histidine kinase CreC. (566 aa)
	bdlA	Methyl-accepting chemotaxis protein CtpH. (558 aa)
	cph1	Histidine kinase-like ATPase. (236 aa)
	cheY_1	Chemotaxis protein CheY. (162 aa)
	aer	Methyl-accepting chemotaxis protein. (554 aa)
	DivK_1	Chemotaxis protein CheY. (145 aa)
	YycG_3	Sensor histidine kinase. (484 aa)
	yfiH	Laccase domain protein yfiH; Belongs to the multicopper oxidase YfiH/RL5 family. (254 aa)
	AIL65656.1	Uncharacterized protein conserved in bacteria. (210 aa)
	ruvB	Holliday junction ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (340 aa)
	recF	DNA replication and repair protein recF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (373 aa)
	uvrB	UvrB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA prein [...] (663 aa)
	pleD_2	Response regulator PleD. (457 aa)
	ctrA	Cell cycle response regulator CtrA. (240 aa)
	pleD_1	Response regulator PleD. (319 aa)
	AIL65060.1	Transcriptional regulatory protein. (225 aa)
	AIL65059.1	Uncharacterized protein conserved in bacteria. (144 aa)
	envZ	Osmolarity sensor protein EnvZ. (441 aa)
	kdpE	KDP operon transcriptional regulatory protein KdpE. (235 aa)
	AIL64733.1	Hypothetical protein. (363 aa)
	AIL64705.1	Two component system sensor kinase SsrA. (422 aa)
	YycG_2	Sensor histidine kinase. (309 aa)
	cqsS	CAI-1 autoinducer sensor kinase/phosphatase CqsS. (299 aa)
	afsQ1_1	Transcriptional regulatory protein AfsQ1. (360 aa)
	YycG_1	Sensor histidine kinase. (785 aa)
	AIL64581.1	Hypothetical protein. (236 aa)
	glnG	Nitrogen regulation protein NR(I). (484 aa)
	uvrC	Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (619 aa)
	evgS	Sensor protein evgS precursor. (769 aa)
	AIL65664.1	RNA polymerase-binding transcription factor CarD. (168 aa)
	YycG_6	Sensor histidine kinase. (603 aa)
	ompR	Transcriptional regulatory protein OmpR. (229 aa)
	zraR	Transcriptional regulatory protein ZraR. (441 aa)
	phoB	Phosphate regulon transcriptional regulatory protein phoB. (245 aa)
	recA	Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (341 aa)
	YycG_7	Sensor histidine kinase. (796 aa)
	AfsQ1_2	Hypothetical protein; Contains HATPase_c and CheY domains. (244 aa)
	LuxQ	Sensor histidine kinase. (796 aa)
	PleC	Sensor histidine kinase. (787 aa)
	YycG_8	Sensor histidine kinase. (613 aa)
	WalK	Sensor histidine kinase. (729 aa)
	ArcB	Sensor histidine kinase. (782 aa)
	mcpB	Methyl-accepting chemotaxis protein. (689 aa)
	AIL65939.2	Hypothetical protein. (873 aa)

Your Current Organism:

Rickettsiales bacterium Ac37b

NCBI taxonomy Id: 1528098
Other names: R. bacterium Ac37b

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIL64581.1	ArcB	NOVO_00855	NOVO_07865	Hypothetical protein.	Sensor histidine kinase.	0.460
AIL64581.1	YycG_2	NOVO_00855	NOVO_01535	Hypothetical protein.	Sensor histidine kinase.	0.727
AIL64581.1	afsQ1_1	NOVO_00855	NOVO_00965	Hypothetical protein.	Transcriptional regulatory protein AfsQ1.	0.428
AIL64705.1	AfsQ1_2	NOVO_01540	NOVO_07750	Two component system sensor kinase SsrA.	Hypothetical protein; Contains HATPase_c and CheY domains.	0.433
AIL64705.1	DivK_2	NOVO_01540	NOVO_05720	Two component system sensor kinase SsrA.	Sensor histidine kinase.	0.433
AIL64705.1	LuxQ	NOVO_01540	NOVO_07760	Two component system sensor kinase SsrA.	Sensor histidine kinase.	0.582
AIL64705.1	PleC	NOVO_01540	NOVO_07780	Two component system sensor kinase SsrA.	Sensor histidine kinase.	0.582
AIL64705.1	YycG_2	NOVO_01540	NOVO_01535	Two component system sensor kinase SsrA.	Sensor histidine kinase.	0.993
AIL64705.1	YycG_5	NOVO_01540	NOVO_06330	Two component system sensor kinase SsrA.	Sensor histidine kinase.	0.582
AIL64705.1	YycG_7	NOVO_01540	NOVO_07425	Two component system sensor kinase SsrA.	Sensor histidine kinase.	0.433
AIL64705.1	YycG_8	NOVO_01540	NOVO_07795	Two component system sensor kinase SsrA.	Sensor histidine kinase.	0.582
AIL64705.1	afsQ1_1	NOVO_01540	NOVO_00965	Two component system sensor kinase SsrA.	Transcriptional regulatory protein AfsQ1.	0.466
AIL64705.1	cph1	NOVO_01540	NOVO_05025	Two component system sensor kinase SsrA.	Histidine kinase-like ATPase.	0.807
AIL64705.1	pleD_1	NOVO_01540	NOVO_03665	Two component system sensor kinase SsrA.	Response regulator PleD.	0.763
AIL64733.1	ArcB	NOVO_01685	NOVO_07865	Hypothetical protein.	Sensor histidine kinase.	0.460
AIL64733.1	YycG_2	NOVO_01685	NOVO_01535	Hypothetical protein.	Sensor histidine kinase.	0.727
AIL64733.1	afsQ1_1	NOVO_01685	NOVO_00965	Hypothetical protein.	Transcriptional regulatory protein AfsQ1.	0.428
AIL65059.1	AIL65060.1	NOVO_03355	NOVO_03360	Uncharacterized protein conserved in bacteria.	Transcriptional regulatory protein.	0.623
AIL65060.1	AIL65059.1	NOVO_03360	NOVO_03355	Transcriptional regulatory protein.	Uncharacterized protein conserved in bacteria.	0.623
AIL65060.1	AIL65656.1	NOVO_03360	NOVO_06530	Transcriptional regulatory protein.	Uncharacterized protein conserved in bacteria.	0.699