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| | AIL65278.1 | Nucleotidyltransferase family protein. (255 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (289 aa) |
| | lptD | LPS-assembly protein LptD precursor; Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane; Belongs to the LptD family. (721 aa) |
| | purF | Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (474 aa) |
| | AIL65497.1 | CDP-diacylglycerol-serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (252 aa) |
| | AIL65499.1 | Pentapeptide repeat protein. (1017 aa) |
| | AIL65506.1 | Hypothetical protein. (327 aa) |
| | DivK_2 | Sensor histidine kinase. (603 aa) |
| | phbC | Poly-beta-hydroxybutyrate polymerase. (586 aa) |
| | scoA | Putative succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A. (232 aa) |
| | scoB | Putative succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B. (212 aa) |
| | eptB | Phosphoethanolamine transferase eptB. (514 aa) |
| | AIL65521.1 | Serine/Threonine kinase. (683 aa) |
| | phbA | Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa) |
| | rlpA | RlpA-like protein precursor; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (280 aa) |
| | glmS | Glucosamine 6-phosphate synthetase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (608 aa) |
| | yrdA | Gamma carbonic anhydrase-like protein. (180 aa) |
| | wecA | Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase. (309 aa) |
| | phoR | Phosphate regulon sensor protein phoR. (452 aa) |
| | rsmE | Ribosomal RNA small subunit methyltransferase E; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (241 aa) |
| | AIL65572.1 | Putative TrmH family tRNA/rRNA methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (247 aa) |
| | rplB | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (275 aa) |
| | secY | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (440 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (222 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (340 aa) |
| | AIL65613.1 | N-glycosyltransferase. (607 aa) |
| | YycG_5 | Sensor histidine kinase. (496 aa) |
| | AIL65619.1 | Hypothetical protein. (134 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (316 aa) |
| | eptA | Phosphoethanolamine transferase eptA. (520 aa) |
| | rph | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (243 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (277 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (287 aa) |
| | cheR | Chemotaxis protein methyltransferase; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (274 aa) |
| | cheA | Chemotaxis protein CheA. (868 aa) |
| | AIL65656.1 | Uncharacterized protein conserved in bacteria. (210 aa) |
| | AIL65659.1 | Cytidylyltransferase family protein. (201 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (601 aa) |
| | AIL65663.1 | Hypothetical protein. (182 aa) |
| | AIL65666.1 | Aminoglycoside N(6')-acetyltransferase type 1. (177 aa) |
| | lysC | Aspartokinase; Belongs to the aspartokinase family. (414 aa) |
| | AIL65674.1 | Transglycosylase SLT domain protein. (257 aa) |
| | AIL65676.1 | Phosphoribosyl transferase domain protein. (210 aa) |
| | AIL65681.1 | Biotin biosynthesis protein BioC. (263 aa) |
| | ubiG | Ubiquinone biosynthesis O-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (240 aa) |
| | YycG_6 | Sensor histidine kinase. (603 aa) |
| | AIL65691.1 | Putative O-methyltransferase. (219 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (210 aa) |
| | AIL65696.1 | Hypothetical protein. (329 aa) |
| | dnaX_2 | DNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (569 aa) |
| | trmJ | tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. (243 aa) |
| | ppdK | Pyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (874 aa) |
| | uppS | Undecaprenyl pyrophosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (233 aa) |
| | cdsA | Phosphatidate cytidylyltransferase. (242 aa) |
| | dacF | D-alanyl-D-alanine carboxypeptidase dacF precursor; Belongs to the peptidase S11 family. (377 aa) |
| | AIL65751.1 | Pentapeptide repeat protein. (1196 aa) |
| | AIL65758.1 | Nitronate monooxygenase. (330 aa) |
| | AIL65764.1 | Putative O-linked N-acetylglucosamine transferase, SPINDLY family. (676 aa) |
| | lnt | Apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (520 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (641 aa) |
| | waaA | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (427 aa) |
| | AIL65811.1 | Uncharacterized protein conserved in bacteria. (225 aa) |
| | AIL65815.1 | Lipoprotein NlpI. (391 aa) |
| | YycG_7 | Sensor histidine kinase. (796 aa) |
| | AIL65825.1 | Hypothetical protein. (128 aa) |
| | rpfC | Sensory/regulatory protein RpfC. (752 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (313 aa) |
| | AIL65847.1 | Hypothetical protein. (56 aa) |
| | fabI | Enoyl-[acyl-carrier-protein] reductase [NADH] FabI. (281 aa) |
| | AfsQ1_2 | Hypothetical protein; Contains HATPase_c and CheY domains. (244 aa) |
| | AIL65887.1 | Methyltransferase domain protein. (354 aa) |
| | LuxQ | Sensor histidine kinase. (796 aa) |
| | AIL65890.1 | Hypothetical protein. (356 aa) |
| | PleC | Sensor histidine kinase. (787 aa) |
| | YycG_8 | Sensor histidine kinase. (613 aa) |
| | WalK | Sensor histidine kinase. (729 aa) |
| | AIL65905.1 | Hypothetical protein. (328 aa) |
| | ArcB | Sensor histidine kinase. (782 aa) |
| | cca | CCA-adding enzyme; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (409 aa) |
| | AIL65917.1 | Hypothetical protein. (289 aa) |
| | trmD | tRNA (guanine-N(1)-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (238 aa) |
| | AIL65925.1 | Hypothetical protein. (341 aa) |
| | AIL65193.1 | ComFC type amidophosphoribosyltransferase. (248 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (195 aa) |
| | RibF_2 | Riboflavin kinase. (133 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (146 aa) |
| | ribE | Riboflavin synthase alpha chain. (202 aa) |
| | ctaB | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (313 aa) |
| | lpxB | Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (389 aa) |
| | coaX | Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (257 aa) |
| | tme | NADP-dependent malic enzyme. (766 aa) |
| | ftsI | Peptidoglycan synthase FtsI precursor. (605 aa) |
| | AIL65979.1 | Rhodanese-related sulfurtransferase. (149 aa) |
| | dnaN | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (398 aa) |
| | trmB | tRNA (guanine-N(7)-)-methyltransferase. (173 aa) |
| | AIL66013.1 | Putative acetyltransferase. (328 aa) |
| | AIL66015.1 | Hypothetical protein. (88 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (249 aa) |
| | ilvE | Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (298 aa) |
| | rlmN | Ribosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (357 aa) |
| | AIL66035.1 | Uncharacterized protein conserved in bacteria. (272 aa) |
| | pipB2 | Pentapeptide repeat protein. (605 aa) |
| | rlmH | Ribosomal RNA large subunit methyltransferase H; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (148 aa) |
| | evgS | Sensor protein evgS precursor. (769 aa) |
| | AIL66068.1 | 4-amino-4-deoxy-L-arabinose transferase. (502 aa) |
| | AIL66076.1 | Hypothetical protein. (56 aa) |
| | AIL66078.1 | Phage portal protein, HK97 family. (361 aa) |
| | ppnK | Putative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (259 aa) |
| | rsmH | Ribosomal RNA small subunit methyltransferase H; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (311 aa) |
| | penA | Penicillin-binding protein 2. (569 aa) |
| | aarA | Citrate synthase; Belongs to the citrate synthase family. (432 aa) |
| | AIL64450.1 | Hypothetical protein. (147 aa) |
| | AIL64451.1 | Hypothetical protein. (204 aa) |
| | bsdB | Phenolic acid decarboxylase subunit B; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (192 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (416 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (365 aa) |
| | ftsW | Cell division protein FtsW; Belongs to the SEDS family. (379 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis methyltransferase ubiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (273 aa) |
| | ubiB | Putative ubiquinone biosynthesis protein UbiB; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. (486 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (130 aa) |
| | thiD | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (268 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (265 aa) |
| | thiE | Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (250 aa) |
| | AIL64545.1 | Spermidine synthase. (683 aa) |
| | AIL64557.1 | Hypothetical protein. (64 aa) |
| | pgsA | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (193 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (427 aa) |
| | AIL64567.1 | Hypothetical protein. (365 aa) |
| | dat | D-alanine aminotransferase. (287 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (223 aa) |
| | AIL64573.1 | Phosphatidylethanolamine-binding protein. (153 aa) |
| | AIL64581.1 | Hypothetical protein. (236 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (355 aa) |
| | AIL64587.1 | DNA polymerase III subunit chi. (154 aa) |
| | YycG_1 | Sensor histidine kinase. (785 aa) |
| | afsQ1_1 | Transcriptional regulatory protein AfsQ1. (360 aa) |
| | AIL64604.1 | Hypothetical protein. (219 aa) |
| | cqsS | CAI-1 autoinducer sensor kinase/phosphatase CqsS. (299 aa) |
| | AIL64611.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase. (241 aa) |
| | tlyA | 16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA. (246 aa) |
| | AIL64616.1 | SAM-dependent methyltransferase. (255 aa) |
| | hisC2 | Histidinol-phosphate aminotransferase 2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (887 aa) |
| | speG | Spermidine N(1)-acetyltransferase. (189 aa) |
| | AIL64671.1 | Tetratricopeptide repeat protein. (247 aa) |
| | bla | Beta-lactamase OXA-1 precursor. (271 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (204 aa) |
| | YycG_2 | Sensor histidine kinase. (309 aa) |
| | AIL64705.1 | Two component system sensor kinase SsrA. (422 aa) |
| | bioF | 8-amino-7-oxononanoate synthase. (371 aa) |
| | znuB | High-affinity zinc uptake system membrane protein znuB. (273 aa) |
| | rsmD | Ribosomal RNA small subunit methyltransferase D. (187 aa) |
| | AIL64725.1 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (296 aa) |
| | mrdB | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (380 aa) |
| | AIL64733.1 | Hypothetical protein. (363 aa) |
| | AIL64759.1 | LemA family protein. (180 aa) |
| | cmk | Cytidylate kinase. (217 aa) |
| | rmlA | Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (313 aa) |
| | rlmCD | 23S rRNA (uracil-C(5))-methyltransferase RlmCD; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (361 aa) |
| | pyrB | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (304 aa) |
| | AIL64781.1 | Spermidine synthase. (581 aa) |
| | miaB_1 | (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB. (427 aa) |
| | arnB | UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase; Belongs to the DegT/DnrJ/EryC1 family. (358 aa) |
| | AIL64808.1 | Hypothetical protein. (189 aa) |
| | AIL64809.1 | Hypothetical protein. (179 aa) |
| | leuA | 2-isopropylmalate synthase. (324 aa) |
| | pnp | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (745 aa) |
| | glyA2 | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa) |
| | dnaE1 | DNA polymerase III subunit alpha. (1144 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (305 aa) |
| | AIL64878.1 | RNA polymerase factor sigma-54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (451 aa) |
| | mraY | Phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (363 aa) |
| | fabD | Malonyl CoA-acyl carrier protein transacylase. (313 aa) |
| | ada | Regulatory protein of adaptative response. (172 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (161 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1386 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1352 aa) |
| | envZ | Osmolarity sensor protein EnvZ. (441 aa) |
| | miaB_2 | (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (446 aa) |
| | AIL64943.1 | Pentapeptide repeats containing protein. (791 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (325 aa) |
| | gtaB | UTP--glucose-1-phosphate uridylyltransferase. (297 aa) |
| | trpD | Anthranilate synthase component II; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (347 aa) |
| | ispDF | Bifunctional enzyme IspD/IspF; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). (393 aa) |
| | AIL64978.1 | Stringent starvation protein A. (206 aa) |
| | mlaC | Putative phospholipid-binding protein mlaC precursor. (204 aa) |
| | lpxA | Acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (265 aa) |
| | fabZ | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (149 aa) |
| | lpxD | UDP-3-O-acylglucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (363 aa) |
| | thyX | Thymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (309 aa) |
| | AIL65007.1 | Squalene synthase HpnD. (282 aa) |
| | AIL65010.1 | Putative nicotinate phosphoribosyltransferase; Belongs to the NAPRTase family. (456 aa) |
| | rsmA | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (276 aa) |
| | ribF | Riboflavin biosynthesis protein ribF; Belongs to the ribF family. (279 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa) |
| | rsfS | Ribosomal silencing factor RsfS; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (127 aa) |
| | hemA | 5-aminolevulinate synthase. (404 aa) |
| | bioC | Malonyl-CoA O-methyltransferase BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (263 aa) |
| | AIL65053.1 | Outer membrane protein W. (251 aa) |
| | prmC | Release factor glutamine methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (288 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (311 aa) |
| | dnaX_1 | DNA polymerase III subunit tau. (330 aa) |
| | folP | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (271 aa) |
| | plsY | G3P acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (212 aa) |
| | yceG | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (339 aa) |
| | fabF | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (418 aa) |
| | fabG_1 | 3-oxoacyl-[acyl-carrier-protein] reductase FabG; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa) |
| | pbpD | Penicillin-binding protein 4 precursor. (635 aa) |
| | pleD_1 | Response regulator PleD. (319 aa) |
| | aroK | Shikimate kinase 1; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (179 aa) |
| | miaA | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (306 aa) |
| | gcp | tRNA N6-adenosine threonylcarbamoyltransferase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (337 aa) |
| | AIL65127.1 | Outer membrane protein W. (210 aa) |
| | AIL65128.1 | Outer membrane protein W. (243 aa) |
| | AIL65129.1 | Outer membrane protein W. (258 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (401 aa) |
| | tktA | Transketolase 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (665 aa) |
| | lgt | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (265 aa) |
| | AIL65146.1 | Uncharacterized protein conserved in bacteria. (169 aa) |
| | AIL65147.1 | Lipid A biosynthesis lauroyl acyltransferase. (291 aa) |
| | purH | Bifunctional purine biosynthesis protein PurH. (519 aa) |
| | AIL65159.1 | Hypothetical protein. (361 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa) |
| | AIL65164.1 | Acetyltransferase (GNAT) family protein. (192 aa) |
| | pleD_2 | Response regulator PleD. (457 aa) |
| | pdhC | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (423 aa) |
| | mnmA | tRNA-specific 2-thiouridylase mnmA; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (365 aa) |
| | ispB | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. (331 aa) |
| | AIL65189.1 | Aspartate aminotransferase. (400 aa) |
| | AIL65190.1 | Biotin biosynthesis protein BioC. (335 aa) |
| | glmU | Bifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (452 aa) |
| | AIL65436.1 | Sensory histidine kinase CreC. (566 aa) |
| | AIL65441.1 | Glycogen synthase. (371 aa) |
| | acpS | Holo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (133 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (243 aa) |
| | mfpsA | GT1 family glycosyltransferase. (360 aa) |
| | rsmI | Ribosomal RNA small subunit methyltransferase I; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (286 aa) |
| | rsmG | Ribosomal RNA small subunit methyltransferase G; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (206 aa) |
| | AIL65242.1 | Beta 1,4 Glucosyltransferase. (265 aa) |
| | cotSA | GT1 family glycosyltransferase. (385 aa) |
| | AIL65244.1 | acyl-CoA esterase. (260 aa) |
| | yfiH | Laccase domain protein yfiH; Belongs to the multicopper oxidase YfiH/RL5 family. (254 aa) |
| | anmK | Anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (400 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (181 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (322 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (346 aa) |
| | AIL65261.1 | Hypothetical protein. (327 aa) |
| | YycG_3 | Sensor histidine kinase. (484 aa) |
| | lipB | Octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (218 aa) |
| | pal | Minor outer membrane protein Omp16; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (160 aa) |
| | fmt | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (303 aa) |
| | dnaQ | DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (226 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (196 aa) |
| | yqfL | Putative phosphotransferase yqfL; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (270 aa) |
| | sucB | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (393 aa) |
| | AIL65309.1 | Hypothetical protein; Belongs to the peptidase S1B family. (139 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (373 aa) |
| | rlmE | Ribosomal RNA large subunit methyltransferase E; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (231 aa) |
| | metK | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (387 aa) |
| | prmA | Ribosomal protein L11 methyltransferase. (321 aa) |
| | arnC | Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase. (308 aa) |
| | AIL65348.1 | Hypothetical protein. (285 aa) |
| | ubiA | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (294 aa) |
| | algA | Alginate biosynthesis protein AlgA; Belongs to the mannose-6-phosphate isomerase type 2 family. (477 aa) |
| | barA | Signal transduction histidine-protein kinase BarA. (1009 aa) |
| | cph1 | Histidine kinase-like ATPase. (236 aa) |
| | rssB | Swarming motility regulation protein rssB. (138 aa) |
| | AIL65386.1 | Aminomethyltransferase related to GcvT; Belongs to the GcvT family. (297 aa) |
| | iscS | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (405 aa) |
| | mrcA | Penicillin-binding protein 1A. (788 aa) |
| | AIL65402.1 | Colanic acid biosynthesis glycosyltransferase WcaL. (341 aa) |
| | AIL65406.1 | Hypothetical protein. (303 aa) |
| | AIL65417.1 | S-adenosylmethionine-dependent methyltransferase. (260 aa) |
| | astC | Succinylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (388 aa) |
