(13 nodes) Vitamin binding network (Rickettsiales bacterium Ac37b)

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Your Input:
	bioF	8-amino-7-oxononanoate synthase. (371 aa)
	AIL64712.1	Hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (218 aa)
	dadX	Alanine racemase, catabolic; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (371 aa)
	glyA2	Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
	bioA	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (416 aa)
	hemA	5-aminolevulinate synthase. (404 aa)
	AIL65189.1	Aspartate aminotransferase. (400 aa)
	sucA	2-oxoglutarate dehydrogenase E1 component. (937 aa)
	iscS	Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (405 aa)
	astC	Succinylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (388 aa)
	lysA	Diaminopimelate decarboxylase. (332 aa)
	hisC2	Histidinol-phosphate aminotransferase 2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa)
	dxs	1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (641 aa)

Your Current Organism:

Rickettsiales bacterium Ac37b

NCBI taxonomy Id: 1528098
Other names: R. bacterium Ac37b

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIL65189.1	astC	NOVO_04030	NOVO_05260	Aspartate aminotransferase.	Succinylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.	0.405
AIL65189.1	hisC2	NOVO_04030	NOVO_01090	Aspartate aminotransferase.	Histidinol-phosphate aminotransferase 2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.935
AIL65189.1	lysA	NOVO_04030	NOVO_05860	Aspartate aminotransferase.	Diaminopimelate decarboxylase.	0.622
AIL65189.1	sucA	NOVO_04030	NOVO_04610	Aspartate aminotransferase.	2-oxoglutarate dehydrogenase E1 component.	0.807
astC	AIL65189.1	NOVO_05260	NOVO_04030	Succinylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.	Aspartate aminotransferase.	0.405
astC	glyA2	NOVO_05260	NOVO_02170	Succinylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.	Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.442
astC	hemA	NOVO_05260	NOVO_03265	Succinylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.	5-aminolevulinate synthase.	0.580
astC	hisC2	NOVO_05260	NOVO_01090	Succinylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.	Histidinol-phosphate aminotransferase 2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.720
astC	lysA	NOVO_05260	NOVO_05860	Succinylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.	Diaminopimelate decarboxylase.	0.463
bioA	bioF	NOVO_00220	NOVO_01545	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	8-amino-7-oxononanoate synthase.	0.987
bioA	hemA	NOVO_00220	NOVO_03265	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	5-aminolevulinate synthase.	0.774
bioF	bioA	NOVO_01545	NOVO_00220	8-amino-7-oxononanoate synthase.	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.987
dadX	glyA2	NOVO_01960	NOVO_02170	Alanine racemase, catabolic; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.	Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.456
glyA2	astC	NOVO_02170	NOVO_05260	Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Succinylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.	0.442
glyA2	dadX	NOVO_02170	NOVO_01960	Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Alanine racemase, catabolic; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.	0.456
glyA2	hemA	NOVO_02170	NOVO_03265	Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	5-aminolevulinate synthase.	0.915
glyA2	lysA	NOVO_02170	NOVO_05860	Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Diaminopimelate decarboxylase.	0.437
glyA2	sucA	NOVO_02170	NOVO_04610	Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	2-oxoglutarate dehydrogenase E1 component.	0.540
hemA	astC	NOVO_03265	NOVO_05260	5-aminolevulinate synthase.	Succinylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.	0.580
hemA	bioA	NOVO_03265	NOVO_00220	5-aminolevulinate synthase.	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.774