STRINGSTRING
AIL65060.1 AIL65060.1 osmY osmY pleD_1 pleD_1 ctrA ctrA pleD_2 pleD_2 uvrB uvrB recF recF nth nth recJ recJ ruvB ruvB ruvA ruvA ruvC ruvC yfiH yfiH YycG_3 YycG_3 DivK_1 DivK_1 aer aer grxC grxC cheY_1 cheY_1 AIL65348.1 AIL65348.1 bdbD_1 bdbD_1 AIL65356.1 AIL65356.1 barA barA cph1 cph1 rssB rssB mrcA mrcA tag tag estB estB bdlA bdlA fliN fliN fliG fliG AIL65436.1 AIL65436.1 AIL65463.1 AIL65463.1 lptD lptD AIL65482.1 AIL65482.1 DivK_2 DivK_2 clpB clpB bcp bcp AIL65549.1 AIL65549.1 phoR phoR motB motB YycG_5 YycG_5 AIL65619.1 AIL65619.1 cheB cheB cheY_2 cheY_2 AIL65654.1 AIL65654.1 cheA cheA AIL65656.1 AIL65656.1 AIL65664.1 AIL65664.1 recO recO AIL65676.1 AIL65676.1 YycG_6 YycG_6 ompR ompR recR recR AIL65699.1 AIL65699.1 zraR zraR phoB phoB recN recN AIL65758.1 AIL65758.1 mfd mfd lon lon recA recA uvrA uvrA ssb ssb AIL65821.1 AIL65821.1 YycG_7 YycG_7 mscM mscM rpfC rpfC mutM mutM AfsQ1_2 AfsQ1_2 LuxQ LuxQ PleC PleC YycG_8 YycG_8 WalK WalK ArcB ArcB dnaJ dnaJ mcpB mcpB AIL65939.2 AIL65939.2 AIL66027.1 AIL66027.1 AIL66030.1 AIL66030.1 radA radA evgS evgS ligA ligA yoaE yoaE tlpA tlpA AIL66116.1 AIL66116.1 AIL66126.1 AIL66126.1 htrA htrA mutS mutS tsaA tsaA trxB trxB AIL64474.1 AIL64474.1 AIL64475.1 AIL64475.1 xthA_1 xthA_1 uvrC uvrC glnG glnG AIL64581.1 AIL64581.1 YycG_1 YycG_1 afsQ1_1 afsQ1_1 cqsS cqsS apaG apaG polA polA bla bla fliM fliM fliL fliL YycG_2 YycG_2 AIL64705.1 AIL64705.1 xthA_2 xthA_2 uspF uspF AIL64727.1 AIL64727.1 AIL64733.1 AIL64733.1 AIL64741.1 AIL64741.1 AIL64874.1 AIL64874.1 ychF ychF mutL mutL kdpE kdpE ada ada envZ envZ sugE sugE cutA cutA sodB sodB AIL65059.1 AIL65059.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AIL65060.1Transcriptional regulatory protein. (225 aa)
osmYOsmotically-inducible protein Y precursor. (198 aa)
pleD_1Response regulator PleD. (319 aa)
ctrACell cycle response regulator CtrA. (240 aa)
pleD_2Response regulator PleD. (457 aa)
uvrBUvrB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA prein [...] (663 aa)
recFDNA replication and repair protein recF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (373 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (211 aa)
recJSingle-stranded-DNA-specific exonuclease recJ. (590 aa)
ruvBHolliday junction ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (340 aa)
ruvAHolliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (201 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (159 aa)
yfiHLaccase domain protein yfiH; Belongs to the multicopper oxidase YfiH/RL5 family. (254 aa)
YycG_3Sensor histidine kinase. (484 aa)
DivK_1Chemotaxis protein CheY. (145 aa)
aerMethyl-accepting chemotaxis protein. (554 aa)
grxCGlutaredoxin-3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. (85 aa)
cheY_1Chemotaxis protein CheY. (162 aa)
AIL65348.1Hypothetical protein. (285 aa)
bdbD_1Thiol-disulfide oxidoreductase D. (264 aa)
AIL65356.1Uncharacterized protein conserved in bacteria. (265 aa)
barASignal transduction histidine-protein kinase BarA. (1009 aa)
cph1Histidine kinase-like ATPase. (236 aa)
rssBSwarming motility regulation protein rssB. (138 aa)
mrcAPenicillin-binding protein 1A. (788 aa)
tagDNA-3-methyladenine glycosylase 1. (191 aa)
estBCarboxylesterase 2. (215 aa)
bdlAMethyl-accepting chemotaxis protein CtpH. (558 aa)
fliNFlagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family. (92 aa)
fliGFlagellar motor switch protein FliG; FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. (339 aa)
AIL65436.1Sensory histidine kinase CreC. (566 aa)
AIL65463.1DnaJ domain protein. (61 aa)
lptDLPS-assembly protein LptD precursor; Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane; Belongs to the LptD family. (721 aa)
AIL65482.1ComEC family competence protein. (669 aa)
DivK_2Sensor histidine kinase. (603 aa)
clpBChaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (853 aa)
bcpPutative peroxiredoxin bcp. (156 aa)
AIL65549.1Peroxiredoxin (PRX)-like protein. (183 aa)
phoRPhosphate regulon sensor protein phoR. (452 aa)
motBChemotaxis protein MotB. (289 aa)
YycG_5Sensor histidine kinase. (496 aa)
AIL65619.1Hypothetical protein. (134 aa)
cheBChemotaxis response regulator protein-glutamate methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (409 aa)
cheY_2Chemotaxis protein CheY. (121 aa)
AIL65654.1Chemotaxis protein CheW. (163 aa)
cheAChemotaxis protein CheA. (868 aa)
AIL65656.1Uncharacterized protein conserved in bacteria. (210 aa)
AIL65664.1RNA polymerase-binding transcription factor CarD. (168 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (243 aa)
AIL65676.1Phosphoribosyl transferase domain protein. (210 aa)
YycG_6Sensor histidine kinase. (603 aa)
ompRTranscriptional regulatory protein OmpR. (229 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (197 aa)
AIL65699.1YbaB/EbfC family DNA-binding protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (100 aa)
zraRTranscriptional regulatory protein ZraR. (441 aa)
phoBPhosphate regulon transcriptional regulatory protein phoB. (245 aa)
recNRecombination protein N; May be involved in recombinational repair of damaged DNA. (552 aa)
AIL65758.1Nitronate monooxygenase. (330 aa)
mfdTranscription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1163 aa)
lonLon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (796 aa)
recARecombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (341 aa)
uvrAUvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (959 aa)
ssbSingle-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (154 aa)
AIL65821.1Hypothetical protein; Belongs to the UPF0246 family. (253 aa)
YycG_7Sensor histidine kinase. (796 aa)
mscMMiniconductance mechanosensitive channel. (392 aa)
rpfCSensory/regulatory protein RpfC. (752 aa)
mutMFormamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (273 aa)
AfsQ1_2Hypothetical protein; Contains HATPase_c and CheY domains. (244 aa)
LuxQSensor histidine kinase. (796 aa)
PleCSensor histidine kinase. (787 aa)
YycG_8Sensor histidine kinase. (613 aa)
WalKSensor histidine kinase. (729 aa)
ArcBSensor histidine kinase. (782 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (378 aa)
mcpBMethyl-accepting chemotaxis protein. (689 aa)
AIL65939.2Hypothetical protein. (873 aa)
AIL66027.1Protein of unknown function (DUF541). (258 aa)
AIL66030.1DoxX membrane protein. (273 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (465 aa)
evgSSensor protein evgS precursor. (769 aa)
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (713 aa)
yoaEIntegral membrane protein TerC. (243 aa)
tlpACytochrome biogenesis protein tlpA. (239 aa)
AIL66116.1Protein of unknown function (DUF541). (270 aa)
AIL66126.1Phage-related protein. (111 aa)
htrAPutative serine protease HtrA. (332 aa)
mutSDNA mismatch repair protein mutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (868 aa)
tsaAPutative peroxiredoxin. (200 aa)
trxBThioredoxin reductase. (315 aa)
AIL64474.1Hypothetical protein. (84 aa)
AIL64475.1Hypothetical protein. (76 aa)
xthA_1Exodeoxyribonuclease III. (263 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (619 aa)
glnGNitrogen regulation protein NR(I). (484 aa)
AIL64581.1Hypothetical protein. (236 aa)
YycG_1Sensor histidine kinase. (785 aa)
afsQ1_1Transcriptional regulatory protein AfsQ1. (360 aa)
cqsSCAI-1 autoinducer sensor kinase/phosphatase CqsS. (299 aa)
apaGCO2+/MG2+ efflux protein ApaG. (131 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (887 aa)
blaBeta-lactamase OXA-1 precursor. (271 aa)
fliMFlagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. (345 aa)
fliLFlagellar FliL protein; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family. (182 aa)
YycG_2Sensor histidine kinase. (309 aa)
AIL64705.1Two component system sensor kinase SsrA. (422 aa)
xthA_2Exodeoxyribonuclease III. (261 aa)
uspFUniversal stress protein F. (142 aa)
AIL64727.1Ferredoxin--NADP reductase. (335 aa)
AIL64733.1Hypothetical protein. (363 aa)
AIL64741.1Conjugal transfer protein TrbD; Type IV secretion system protein virB3. (107 aa)
AIL64874.1Uracil DNA glycosylase superfamily protein. (196 aa)
ychFRibosome-binding ATPase YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (363 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (619 aa)
kdpEKDP operon transcriptional regulatory protein KdpE. (235 aa)
adaRegulatory protein of adaptative response. (172 aa)
envZOsmolarity sensor protein EnvZ. (441 aa)
sugEQuaternary ammonium compound-resistance protein sugE. (106 aa)
cutADivalent-cation tolerance protein CutA. (103 aa)
sodBSuperoxide dismutase [Fe]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (216 aa)
AIL65059.1Uncharacterized protein conserved in bacteria. (144 aa)
Your Current Organism:
Rickettsiales bacterium Ac37b
NCBI taxonomy Id: 1528098
Other names: R. bacterium Ac37b
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