(36 nodes) Transferase complex network (Rickettsiales bacterium Ac37b)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	iscA	Iron-sulfur cluster assembly protein; Belongs to the HesB/IscA family. (113 aa)
	hscB	Co-chaperone protein hscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (184 aa)
	AIL65473.1	DNA polymerase III subunit delta. (338 aa)
	rpoA	DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (340 aa)
	dnaG	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (601 aa)
	sigA	RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (666 aa)
	dnaX_2	DNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (569 aa)
	prs	Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa)
	ribH	6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (146 aa)
	AIL65960.1	Ribonuclease J 1. (565 aa)
	dnaN	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (398 aa)
	trmB	tRNA (guanine-N(7)-)-methyltransferase. (173 aa)
	traC	DNA primase TraC. (319 aa)
	AIL66025.1	PAS fold protein. (307 aa)
	rpoH	RNA polymerase sigma-32 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (293 aa)
	ybjQ	Heavy-metal-binding protein; Belongs to the UPF0145 family. (111 aa)
	rpoC	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1386 aa)
	sucB	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (393 aa)
	sucA	2-oxoglutarate dehydrogenase E1 component. (937 aa)
	dnaQ	DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (226 aa)
	dnaX_1	DNA polymerase III subunit tau. (330 aa)
	AIL65011.1	Bifunctional NMN adenylyltransferase/Nudix hydrolase. (349 aa)
	AIL64942.1	Hypothetical protein; Belongs to the UPF0758 family. (229 aa)
	rplK	Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (146 aa)
	rplA	Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (240 aa)
	suhB	Inositol-1-monophosphatase. (259 aa)
	AIL64878.1	RNA polymerase factor sigma-54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (451 aa)
	dnaE1	DNA polymerase III subunit alpha. (1144 aa)
	AIL64798.1	Hypothetical protein. (99 aa)
	pyrB	Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (304 aa)
	AIL64639.1	Hypothetical protein. (303 aa)
	AIL64587.1	DNA polymerase III subunit chi. (154 aa)
	dgt	Deoxyguanosinetriphosphate triphosphohydrolase; Belongs to the dGTPase family. Type 2 subfamily. (389 aa)
	rpoZ	DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (130 aa)
	rpoB	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1352 aa)
	nifU	NifU-like protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (134 aa)

Your Current Organism:

Rickettsiales bacterium Ac37b

NCBI taxonomy Id: 1528098
Other names: R. bacterium Ac37b

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIL64587.1	AIL65473.1	NOVO_00885	NOVO_05525	DNA polymerase III subunit chi.	DNA polymerase III subunit delta.	0.995
AIL64587.1	dnaE1	NOVO_00885	NOVO_02200	DNA polymerase III subunit chi.	DNA polymerase III subunit alpha.	0.997
AIL64587.1	dnaN	NOVO_00885	NOVO_08275	DNA polymerase III subunit chi.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.981
AIL64587.1	dnaQ	NOVO_00885	NOVO_04560	DNA polymerase III subunit chi.	DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.	0.934
AIL64587.1	dnaX_1	NOVO_00885	NOVO_03565	DNA polymerase III subunit chi.	DNA polymerase III subunit tau.	0.997
AIL64587.1	dnaX_2	NOVO_00885	NOVO_06760	DNA polymerase III subunit chi.	DNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.997
AIL64798.1	dnaN	NOVO_02015	NOVO_08275	Hypothetical protein.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.883
AIL64798.1	dnaX_2	NOVO_02015	NOVO_06760	Hypothetical protein.	DNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.410
AIL64878.1	rpoA	NOVO_02420	NOVO_06225	RNA polymerase factor sigma-54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.969
AIL64878.1	rpoB	NOVO_02420	NOVO_02635	RNA polymerase factor sigma-54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.967
AIL64878.1	rpoC	NOVO_02420	NOVO_02630	RNA polymerase factor sigma-54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.965
AIL64878.1	rpoZ	NOVO_02420	NOVO_00615	RNA polymerase factor sigma-54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.922
AIL65011.1	dnaQ	NOVO_03110	NOVO_04560	Bifunctional NMN adenylyltransferase/Nudix hydrolase.	DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.	0.452
AIL65473.1	AIL64587.1	NOVO_05525	NOVO_00885	DNA polymerase III subunit delta.	DNA polymerase III subunit chi.	0.995
AIL65473.1	dnaE1	NOVO_05525	NOVO_02200	DNA polymerase III subunit delta.	DNA polymerase III subunit alpha.	0.997
AIL65473.1	dnaN	NOVO_05525	NOVO_08275	DNA polymerase III subunit delta.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.997
AIL65473.1	dnaQ	NOVO_05525	NOVO_04560	DNA polymerase III subunit delta.	DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.	0.971
AIL65473.1	dnaX_1	NOVO_05525	NOVO_03565	DNA polymerase III subunit delta.	DNA polymerase III subunit tau.	0.998
AIL65473.1	dnaX_2	NOVO_05525	NOVO_06760	DNA polymerase III subunit delta.	DNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.998
dgt	dnaG	NOVO_00830	NOVO_06550	Deoxyguanosinetriphosphate triphosphohydrolase; Belongs to the dGTPase family. Type 2 subfamily.	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.	0.611