(19 nodes) Homologous recombination network (Rickettsiales bacterium Ac37b)

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Your Input:
	AIL64587.1	DNA polymerase III subunit chi. (154 aa)
	polA	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (887 aa)
	dnaE1	DNA polymerase III subunit alpha. (1144 aa)
	dnaX_1	DNA polymerase III subunit tau. (330 aa)
	recF	DNA replication and repair protein recF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (373 aa)
	recJ	Single-stranded-DNA-specific exonuclease recJ. (590 aa)
	ruvB	Holliday junction ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (340 aa)
	ruvA	Holliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (201 aa)
	ruvC	Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (159 aa)
	dnaQ	DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (226 aa)
	AIL65473.1	DNA polymerase III subunit delta. (338 aa)
	recG	ATP-dependent DNA helicase recG. (699 aa)
	recO	DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (243 aa)
	recR	Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (197 aa)
	dnaX_2	DNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (569 aa)
	recA	Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (341 aa)
	ssb	Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (154 aa)
	dnaN	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (398 aa)
	priA	Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (744 aa)

Your Current Organism:

Rickettsiales bacterium Ac37b

NCBI taxonomy Id: 1528098
Other names: R. bacterium Ac37b

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIL64587.1	AIL65473.1	NOVO_00885	NOVO_05525	DNA polymerase III subunit chi.	DNA polymerase III subunit delta.	0.995
AIL64587.1	dnaE1	NOVO_00885	NOVO_02200	DNA polymerase III subunit chi.	DNA polymerase III subunit alpha.	0.997
AIL64587.1	dnaN	NOVO_00885	NOVO_08275	DNA polymerase III subunit chi.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.981
AIL64587.1	dnaQ	NOVO_00885	NOVO_04560	DNA polymerase III subunit chi.	DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.	0.934
AIL64587.1	dnaX_1	NOVO_00885	NOVO_03565	DNA polymerase III subunit chi.	DNA polymerase III subunit tau.	0.997
AIL64587.1	dnaX_2	NOVO_00885	NOVO_06760	DNA polymerase III subunit chi.	DNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.997
AIL64587.1	polA	NOVO_00885	NOVO_01190	DNA polymerase III subunit chi.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.457
AIL64587.1	recO	NOVO_00885	NOVO_06610	DNA polymerase III subunit chi.	DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.	0.669
AIL64587.1	ssb	NOVO_00885	NOVO_07395	DNA polymerase III subunit chi.	Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	0.968
AIL65473.1	AIL64587.1	NOVO_05525	NOVO_00885	DNA polymerase III subunit delta.	DNA polymerase III subunit chi.	0.995
AIL65473.1	dnaE1	NOVO_05525	NOVO_02200	DNA polymerase III subunit delta.	DNA polymerase III subunit alpha.	0.997
AIL65473.1	dnaN	NOVO_05525	NOVO_08275	DNA polymerase III subunit delta.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.997
AIL65473.1	dnaQ	NOVO_05525	NOVO_04560	DNA polymerase III subunit delta.	DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.	0.971
AIL65473.1	dnaX_1	NOVO_05525	NOVO_03565	DNA polymerase III subunit delta.	DNA polymerase III subunit tau.	0.998
AIL65473.1	dnaX_2	NOVO_05525	NOVO_06760	DNA polymerase III subunit delta.	DNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.998
AIL65473.1	polA	NOVO_05525	NOVO_01190	DNA polymerase III subunit delta.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.585
AIL65473.1	recO	NOVO_05525	NOVO_06610	DNA polymerase III subunit delta.	DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.	0.693
dnaE1	AIL64587.1	NOVO_02200	NOVO_00885	DNA polymerase III subunit alpha.	DNA polymerase III subunit chi.	0.997
dnaE1	AIL65473.1	NOVO_02200	NOVO_05525	DNA polymerase III subunit alpha.	DNA polymerase III subunit delta.	0.997
dnaE1	dnaN	NOVO_02200	NOVO_08275	DNA polymerase III subunit alpha.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.997