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| | acnA | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (898 aa) |
| | ALE18426.1 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (697 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (370 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (260 aa) |
| | pgk | Phosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (403 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa) |
| | rpe | Ribulose phosphate epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (219 aa) |
| | porC | 2-oxoacid:acceptor oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa) |
| | porA | Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (426 aa) |
| | ALE18487.1 | Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa) |
| | sfrB | Glutamate synthase; Unknown function; Derived by automated computational analysis using gene prediction method: Protein Homology. (552 aa) |
| | ppgK | Polyphosphate glucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa) |
| | fruA | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (689 aa) |
| | ptsH | Serine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (86 aa) |
| | leuD | Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (195 aa) |
| | leuC | Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (480 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (338 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa) |
| | ilvH | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (167 aa) |
| | ilvB1 | Acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (620 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (614 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (346 aa) |
| | kgd | Alpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology. (1239 aa) |
| | ALE19574.1 | Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa) |
| | aspA | Aspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (480 aa) |
| | fumA | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (559 aa) |
| | pflA | Pyruvate formate lyase-activating protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa) |
| | pflB | Formate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (753 aa) |
| | ALE18643.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (123 aa) |
| | ALE18644.1 | Zinc-binding dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa) |
| | ALE19582.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa) |
| | glpX | Type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa) |
| | sucD | succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa) |
| | sucC | succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa) |
| | pgi | Glucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (575 aa) |
| | ALE18712.1 | Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa) |
| | ALE19598.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (425 aa) |
| | xylB | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (522 aa) |
| | gpmA | Phosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (254 aa) |
| | deoC | Hypothetical protein; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (244 aa) |
| | frdB | Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa) |
| | sdhA | Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (669 aa) |
| | ALE19627.1 | Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (492 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa) |
| | ALE18885.1 | Hypothetical protein; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (711 aa) |
| | ALE18928.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa) |
| | ALE18930.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa) |
| | ALE19639.1 | Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (537 aa) |
| | ALE19643.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1647 aa) |
| | ALE19644.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (613 aa) |
| | ALE18986.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa) |
| | ALE18987.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (492 aa) |
| | ALE18988.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (2036 aa) |
| | ALE18989.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (3412 aa) |
| | ALE18995.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (613 aa) |
| | ALE19000.1 | Succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (519 aa) |
| | ALE19062.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa) |
| | kstD | 3-oxosteroid 1-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa) |
| | ALE19065.1 | acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (672 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (619 aa) |
| | queE | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa) |
| | ALE19089.1 | Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (587 aa) |
| | pckG-2 | Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (608 aa) |
| | fba | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (344 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (605 aa) |
| | ALE19682.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (86 aa) |
| | mrpD | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (511 aa) |
| | mrpC | NADH-ubiquinone oxidoreductase subunit 4L; Derived by automated computational analysis using gene prediction method: Protein Homology. (111 aa) |
| | ALE19197.1 | Enoate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (756 aa) |
| | ALE19205.1 | LacI family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa) |
| | icd | Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (406 aa) |
| | ALE19734.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa) |
| | fas2 | Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa) |
| | ALE19333.1 | Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (85 aa) |
| | nuoN | NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (520 aa) |
| | ALE19743.1 | NADH:ubiquinone oxidoreductase subunit L; Derived by automated computational analysis using gene prediction method: Protein Homology. (632 aa) |
| | nuoK | NADH:ubiquinone oxidoreductase subunit K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (99 aa) |
| | ALE19744.1 | NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (273 aa) |
| | nuoI | NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (179 aa) |
| | nuoG | NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (776 aa) |
| | nuoF | NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (438 aa) |
| | nuoE | NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa) |
| | nuoD | NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family. (456 aa) |
| | nuoC | NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 30 kDa subunit family. (222 aa) |
| | nuoB | NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (190 aa) |
| | nuoA | NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (119 aa) |
| | ALE19393.1 | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa) |
| | ALE19394.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (106 aa) |
| | ALE19417.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (681 aa) |
| | ilvE | Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa) |
| | ALE19425.1 | Glucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (428 aa) |
| | ALE19467.1 | Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa) |
| | ALE19475.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa) |
| | gdh | Converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (446 aa) |
