STRINGSTRING
pgk pgk gmk gmk aroK aroK relA relA ppgK ppgK galK galK ribF ribF pyrH pyrH thiL thiL pfkA pfkA thrB thrB coaA coaA prs prs ispE ispE ALE19592.1 ALE19592.1 ALE18751.1 ALE18751.1 ALE19609.1 ALE19609.1 adk adk xylB xylB ALE19620.1 ALE19620.1 senX3 senX3 ALE18856.1 ALE18856.1 ALE18876.1 ALE18876.1 pknG pknG ackA ackA glpK glpK ALE18995.1 ALE18995.1 ALE19666.1 ALE19666.1 ALE19131.1 ALE19131.1 ask ask folK folK ALE19698.1 ALE19698.1 glpK-2 glpK-2 ALE19714.1 ALE19714.1 ALE19290.1 ALE19290.1 ndk ndk proB proB adoK adoK ALE19425.1 ALE19425.1 ALE19467.1 ALE19467.1 coaE coaE thiD thiD argB argB ALE19497.1 ALE19497.1 nadK nadK ALE19504.1 ALE19504.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (403 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (181 aa)
aroKHypothetical protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (183 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (761 aa)
ppgKPolyphosphate glucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
galKHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GHMP kinase family. GalK subfamily. (435 aa)
ribFHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (345 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (243 aa)
thiLHypothetical protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (379 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (346 aa)
thrBSerine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (301 aa)
coaAPantothenate kinase; Catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (325 aa)
ispE4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (311 aa)
ALE19592.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (490 aa)
ALE18751.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
ALE19609.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (181 aa)
xylBHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (522 aa)
ALE19620.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
senX3Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (420 aa)
ALE18856.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (365 aa)
ALE18876.1Polyphosphate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
pknGHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (829 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (507 aa)
ALE18995.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (613 aa)
ALE19666.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the fructosamine kinase family. (305 aa)
ALE19131.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
askAspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (421 aa)
folKHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa)
ALE19698.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (496 aa)
glpK-2Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (506 aa)
ALE19714.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
ALE19290.1Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa)
proBGamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa)
adoKRibokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
ALE19425.1Glucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
ALE19467.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
coaEHypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (196 aa)
thiDPhosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (316 aa)
ALE19497.1Protein YcaR in KDO2-Lipid A biosynthesis cluster; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0434 family. (73 aa)
nadKHypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (320 aa)
ALE19504.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
Your Current Organism:
Lawsonella clevelandensis
NCBI taxonomy Id: 1528099
Other names: CCUG 66657, Corynebacteriales bacterium CCF1, Corynebacteriales bacterium CCF2, Corynebacteriales bacterium X1036, Corynebacteriales bacterium X1698, Corynebacterineae bacterium NML 120705, Corynebacterineae bacterium X1698, DSM 45743, L. clevelandensis, Lawsonella clevelandensis Bell et al. 2016, bacterium CCF-01, strain X1036
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