STRINGSTRING
ALE18400.1 ALE18400.1 pafA pafA ALE18404.1 ALE18404.1 arc arc ALE18414.1 ALE18414.1 tpiA tpiA pgk pgk gap gap rpe rpe ALE18460.1 ALE18460.1 pdxT pdxT ALE18474.1 ALE18474.1 dut dut ALE18489.1 ALE18489.1 galT galT pnp pnp ALE18545.1 ALE18545.1 rnhB rnhB ALE18583.1 ALE18583.1 pfkA pfkA ALE18599.1 ALE18599.1 ALE18602.1 ALE18602.1 xseA xseA xseB xseB ALE19582.1 ALE19582.1 eno eno ALE19584.1 ALE19584.1 crt crt pgi pgi cysQ cysQ ALE18756.1 ALE18756.1 fucA fucA gpmA gpmA deoC deoC ALE19627.1 ALE19627.1 fbpA fbpA ALE19635.1 ALE19635.1 ALE18929.1 ALE18929.1 ALE18933.1 ALE18933.1 ALE18967.1 ALE18967.1 ALE18975.1 ALE18975.1 ALE18976.1 ALE18976.1 glpK glpK gpmA_2 gpmA_2 ALE18995.1 ALE18995.1 ALE19647.1 ALE19647.1 ALE19001.1 ALE19001.1 cwlM cwlM ALE19043.1 ALE19043.1 ALE19044.1 ALE19044.1 ALE19045.1 ALE19045.1 ALE19046.1 ALE19046.1 ALE19062.1 ALE19062.1 ALE19069.1 ALE19069.1 ALE19071.1 ALE19071.1 ALE19075.1 ALE19075.1 ALE19665.1 ALE19665.1 ALE19672.1 ALE19672.1 ALE19149.1 ALE19149.1 fba fba ALE19158.1 ALE19158.1 ALE19164.1 ALE19164.1 ALE19173.1 ALE19173.1 ALE19188.1 ALE19188.1 ALE19245.1 ALE19245.1 glpK-2 glpK-2 ALE19256.1 ALE19256.1 ALE19720.1 ALE19720.1 ALE19726.1 ALE19726.1 suhB_2 suhB_2 rph rph ALE19320.1 ALE19320.1 dgt dgt ald ald ALE19408.1 ALE19408.1 ALE19417.1 ALE19417.1 ALE19759.1 ALE19759.1 ALE19467.1 ALE19467.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALE18400.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (887 aa)
pafAPup--protein ligase; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. (458 aa)
ALE18404.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (520 aa)
arcAAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (566 aa)
ALE18414.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (557 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (260 aa)
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (403 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa)
rpeRibulose phosphate epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (219 aa)
ALE18460.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
pdxTGlutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (201 aa)
ALE18474.1Diadenosine tetraphosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (158 aa)
ALE18489.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the inositol monophosphatase superfamily. (309 aa)
galTGalactose-1-phosphate uridylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (393 aa)
pnpPolynucleotide phosphorylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (747 aa)
ALE18545.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (203 aa)
ALE18583.12-hydroxyhepta-2,4-diene-1,7-dioate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (346 aa)
ALE18599.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (714 aa)
ALE18602.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (699 aa)
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (419 aa)
xseBExodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (91 aa)
ALE19582.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
ALE19584.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
crtHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (575 aa)
cysQMFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
ALE18756.1ATP synthase F0 subunit B; Derived by automated computational analysis using gene prediction method: Protein Homology. (453 aa)
fucAHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (254 aa)
deoCHypothetical protein; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (244 aa)
ALE19627.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (492 aa)
fbpAHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
ALE19635.1Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
ALE18929.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
ALE18933.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
ALE18967.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
ALE18975.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
ALE18976.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (438 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (507 aa)
gpmA_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate mutase family. (332 aa)
ALE18995.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (613 aa)
ALE19647.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (320 aa)
ALE19001.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
cwlMHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
ALE19043.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
ALE19044.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
ALE19045.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
ALE19046.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
ALE19062.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
ALE19069.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
ALE19071.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
ALE19075.1Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (422 aa)
ALE19665.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
ALE19672.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
ALE19149.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
fbaFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (344 aa)
ALE19158.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
ALE19164.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (340 aa)
ALE19173.1LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa)
ALE19188.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
ALE19245.1Gamma-glutamyl cyclotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
glpK-2Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (506 aa)
ALE19256.1Glycerol-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (520 aa)
ALE19720.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
ALE19726.1Histidinol phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa)
suhB_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (259 aa)
ALE19320.1Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (229 aa)
dgtDeoxyguanosinetriphosphate triphosphohydrolase; dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (437 aa)
aldAlanine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the AlaDH/PNT family. (367 aa)
ALE19408.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
ALE19417.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (681 aa)
ALE19759.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
ALE19467.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
Your Current Organism:
Lawsonella clevelandensis
NCBI taxonomy Id: 1528099
Other names: CCUG 66657, Corynebacteriales bacterium CCF1, Corynebacteriales bacterium CCF2, Corynebacteriales bacterium X1036, Corynebacteriales bacterium X1698, Corynebacterineae bacterium NML 120705, Corynebacterineae bacterium X1698, DSM 45743, L. clevelandensis, Lawsonella clevelandensis Bell et al. 2016, bacterium CCF-01, strain X1036
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