STRINGSTRING
ogt ogt bioB bioB ALE18400.1 ALE18400.1 ALE18420.1 ALE18420.1 sufC sufC argC argC ALE18422.1 ALE18422.1 ALE18423.1 ALE18423.1 gap gap ALE18454.1 ALE18454.1 ALE18456.1 ALE18456.1 pdxS pdxS ALE19540.1 ALE19540.1 argA argA ribF ribF ALE19551.1 ALE19551.1 hemH hemH sdh_1 sdh_1 menF menF ALE18583.1 ALE18583.1 ALE18595.1 ALE18595.1 ALE19559.1 ALE19559.1 ALE18601.1 ALE18601.1 ALE19570.1 ALE19570.1 ALE18620.1 ALE18620.1 metE metE ALE18626.1 ALE18626.1 ychF ychF crt crt ispE ispE ALE19479.1 ALE19479.1 ALE19589.1 ALE19589.1 ALE19590.1 ALE19590.1 serC serC ALE18725.1 ALE18725.1 ALE19608.1 ALE19608.1 ALE18762.1 ALE18762.1 truA truA rpsM rpsM rplP rplP rpsS rpsS argB argB rpsL rpsL ALE18835.1 ALE18835.1 deoC deoC ALE18866.1 ALE18866.1 tadA tadA pheA pheA ALE19065.1 ALE19065.1 ALE19662.1 ALE19662.1 ALE19083.1 ALE19083.1 ALE19664.1 ALE19664.1 ALE19101.1 ALE19101.1 clpB clpB leuA leuA ALE19167.1 ALE19167.1 nth nth ALE19179.1 ALE19179.1 folK folK draG draG purD purD ALE19700.1 ALE19700.1 purF purF ALE19231.1 ALE19231.1 ALE19235.1 ALE19235.1 ALE19236.1 ALE19236.1 ALE19264.1 ALE19264.1 ALE19267.1 ALE19267.1 ALE19723.1 ALE19723.1 pabB pabB ALE19733.1 ALE19733.1 ALE19318.1 ALE19318.1 fas2 fas2 ALE19736.1 ALE19736.1 nadD nadD ybeY ybeY ALE19743.1 ALE19743.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ogtHypothetical protein; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (185 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (339 aa)
ALE18400.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (887 aa)
ALE18420.1Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (412 aa)
sufCCysteine desulfurase; Part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (353 aa)
ALE18422.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
ALE18423.1Fe-S cluster assembly protein SufB; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa)
ALE18454.1Hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (164 aa)
ALE18456.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (297 aa)
ALE19540.1DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (835 aa)
argAN-acetylglutamate synthase; Catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetyltransferase family. (181 aa)
ribFHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (345 aa)
ALE19551.1Recombinase XerC; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 'phage' integrase family. (296 aa)
hemHHypothetical protein; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (337 aa)
sdh_1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (279 aa)
menFHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
ALE18583.12-hydroxyhepta-2,4-diene-1,7-dioate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
ALE18595.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
ALE19559.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (320 aa)
ALE18601.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
ALE19570.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
ALE18620.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (973 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (771 aa)
ALE18626.1Magnesium transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
ychFGTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (359 aa)
crtHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
ispE4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (311 aa)
ALE19479.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (604 aa)
ALE19589.1Dolichyl-phosphate-mannose-protein mannosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (505 aa)
ALE19590.1protein-S-isoprenylcysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (373 aa)
ALE18725.1Nitroreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
ALE19608.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
ALE18762.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
truAPseudouridine synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (278 aa)
rpsM30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (122 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (138 aa)
rpsS30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (316 aa)
rpsL30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (123 aa)
ALE18835.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycosyl hydrolase 35 family. (1064 aa)
deoCHypothetical protein; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (244 aa)
ALE18866.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
tadAHypothetical protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (165 aa)
pheAPrephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
ALE19065.1acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (672 aa)
ALE19662.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (96 aa)
ALE19083.1Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (542 aa)
ALE19664.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (553 aa)
ALE19101.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
clpBClp protease ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (858 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (605 aa)
ALE19167.1Catalase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the catalase family. (499 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (270 aa)
ALE19179.1DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (830 aa)
folKHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa)
draGHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (441 aa)
ALE19700.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (520 aa)
ALE19231.14-hydroxybutyrate CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
ALE19235.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
ALE19236.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
ALE19264.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
ALE19267.1Cation diffusion facilitator family transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
ALE19723.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
pabBHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (874 aa)
ALE19733.1ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (672 aa)
ALE19318.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
fas2Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
ALE19736.1Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (507 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (221 aa)
ybeYHeat-shock protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (156 aa)
ALE19743.1NADH:ubiquinone oxidoreductase subunit L; Derived by automated computational analysis using gene prediction method: Protein Homology. (632 aa)
Your Current Organism:
Lawsonella clevelandensis
NCBI taxonomy Id: 1528099
Other names: CCUG 66657, Corynebacteriales bacterium CCF1, Corynebacteriales bacterium CCF2, Corynebacteriales bacterium X1036, Corynebacteriales bacterium X1698, Corynebacterineae bacterium NML 120705, Corynebacterineae bacterium X1698, DSM 45743, L. clevelandensis, Lawsonella clevelandensis Bell et al. 2016, bacterium CCF-01, strain X1036
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