(69 nodes) DNA replication network (Torrubiella hemipterigena)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

gene neighborhood

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Your Input:
	VHEMI01050	DNA helicase; Belongs to the MCM family. (720 aa)
	VHEMI10766	Putative Polyprotein. (1525 aa)
	VHEMI10645	Uncharacterized protein. (424 aa)
	VHEMI10379	DNA helicase; Belongs to the MCM family. (944 aa)
	VHEMI10759	Putative Pol-like protein. (642 aa)
	VHEMI10380	Uncharacterized protein. (154 aa)
	VHEMI10024	Putative Cell cycle control protein cwf16. (279 aa)
	VHEMI09867	Uncharacterized protein. (226 aa)
	VHEMI08702	Putative DNA polymerase alpha/epsilon subunit B. (772 aa)
	VHEMI08448	Uncharacterized protein. (651 aa)
	VHEMI08508	Uncharacterized protein. (1225 aa)
	VHEMI08150	Uncharacterized protein. (763 aa)
	VHEMI07663	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (516 aa)
	VHEMI07641	DNA ligase. (859 aa)
	VHEMI07205	Uncharacterized protein. (149 aa)
	VHEMI07316	Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (321 aa)
	VHEMI07185	CCHC-type domain-containing protein. (430 aa)
	VHEMI06057	Putative UDP-galactopyranose mutase. (499 aa)
	VHEMI06723	Putative Whole genome shotgun sequence assembly, scaffold_30, strain Mel28. (718 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (807 aa)
	VHEMI06221	Macro domain-containing protein. (205 aa)
	VHEMI06299	DNA helicase; Belongs to the MCM family. (1014 aa)
	VHEMI04989	Uncharacterized protein. (499 aa)
	VHEMI09774	Putative YALI0F12793p. (901 aa)
	VHEMI09434	DNA ligase. (842 aa)
	VHEMI04014	Putative Proliferating cell nuclear antigen. (645 aa)
	VHEMI10765	Uncharacterized protein. (597 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (394 aa)
	VHEMI10668	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa)
	VHEMI03335	Uncharacterized protein. (106 aa)
	VHEMI04015	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
	VHEMI04073	RNase H domain-containing protein. (160 aa)
	VHEMI10198	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (600 aa)
	VHEMI03807	Putative Replication factor C subunit 5. (354 aa)
	VHEMI03809	Replication factor C subunit 1. (1014 aa)
	VHEMI03464	Putative Exocyst complex component EXO84. (671 aa)
	VHEMI07522	AAA domain-containing protein. (1189 aa)
	VHEMI07412	Uncharacterized protein. (378 aa)
	VHEMI07393	Putative DNA replication factor Dna2. (1542 aa)
	VHEMI07110	DNA polymerase. (1636 aa)
	VHEMI01847	Putative Replication factor C subunit 2. (382 aa)
	VHEMI02599	Uncharacterized protein. (519 aa)
	VHEMI08851	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (501 aa)
	VHEMI01586	Zn(2)-C6 fungal-type domain-containing protein. (635 aa)
	VHEMI02373	Putative DNA polymerase epsilon subunit D. (252 aa)
	VHEMI08509	CCHC-type domain-containing protein. (680 aa)
	VHEMI01172	DNA polymerase. (1107 aa)
	VHEMI01144	Putative Activator 1 37 kDa subunit. (358 aa)
	VHEMI06082	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2221 aa)
	VHEMI08255	Uncharacterized protein. (451 aa)
	VHEMI06040	DNA helicase; Belongs to the MCM family. (862 aa)
	VHEMI08152	Putative DNA replication ATPase. (577 aa)
	VHEMI01522	Uncharacterized protein. (273 aa)
	VHEMI00564	Putative Histone-like transcription factor and archaeal histone. (189 aa)
	VHEMI07229	BRCT domain-containing protein. (292 aa)
	VHEMI00723	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (348 aa)
	VHEMI00461	DNA helicase; Belongs to the MCM family. (889 aa)
	VHEMI04621	Uncharacterized protein. (1090 aa)
	VHEMI00165	Putative Replication factor C subunit 3. (392 aa)
	VHEMI03197	RNase H domain-containing protein. (283 aa)
	VHEMI05289	Putative Single-stranded DNA-binding protein. (137 aa)
	VHEMI02819	Uncharacterized protein. (184 aa)
	VHEMI03592	Uncharacterized protein. (268 aa)
	VHEMI01039	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (657 aa)
	VHEMI00200	Putative DUF1168 domain protein. (216 aa)
	VHEMI00190	Putative UDP-galactopyranose mutase. (536 aa)
	VHEMI01525	DNA polymerase. (1459 aa)
	VHEMI01244	Putative DNA polymerase delta subunit 2. (499 aa)
	VHEMI00160	Uncharacterized protein. (198 aa)

Your Current Organism:

Torrubiella hemipterigena

NCBI taxonomy Id: 1531966
Other names: T. hemipterigena, Verticillium hemipterigenum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	MCM7	A0A0A1TDZ2	A0A0A1TJ23	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.723
FEN1	VHEMI00160	A0A0A1TDZ2	A0A0A1SIG9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.821
FEN1	VHEMI00165	A0A0A1TDZ2	A0A0A1T1F9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Putative Replication factor C subunit 3.	0.900
FEN1	VHEMI00461	A0A0A1TDZ2	A0A0A1T2F5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.919
FEN1	VHEMI00723	A0A0A1TDZ2	A0A0A1T2R4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.762
FEN1	VHEMI01039	A0A0A1TDZ2	A0A0A1SS08	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.830
FEN1	VHEMI01050	A0A0A1TDZ2	A0A0A1SKV4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.922
FEN1	VHEMI01144	A0A0A1TDZ2	A0A0A1T6K9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Putative Activator 1 37 kDa subunit.	0.920
FEN1	VHEMI01172	A0A0A1TDZ2	A0A0A1T6P6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.990
FEN1	VHEMI01244	A0A0A1TDZ2	A0A0A1SLE0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Putative DNA polymerase delta subunit 2.	0.968
FEN1	VHEMI01522	A0A0A1TDZ2	A0A0A1T5M0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.896
FEN1	VHEMI01525	A0A0A1TDZ2	A0A0A1SM55	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.896
FEN1	VHEMI01586	A0A0A1TDZ2	A0A0A1T7X2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Zn(2)-C6 fungal-type domain-containing protein.	0.438
FEN1	VHEMI01847	A0A0A1TDZ2	A0A0A1T8Q1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Putative Replication factor C subunit 2.	0.937
FEN1	VHEMI02373	A0A0A1TDZ2	A0A0A1T7P0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Putative DNA polymerase epsilon subunit D.	0.776
FEN1	VHEMI02819	A0A0A1TDZ2	A0A0A1SWU8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.438
FEN1	VHEMI03197	A0A0A1TDZ2	A0A0A1SXY1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	RNase H domain-containing protein.	0.438
FEN1	VHEMI03592	A0A0A1TDZ2	A0A0A1ST02	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.861
FEN1	VHEMI03807	A0A0A1TDZ2	A0A0A1TCC2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Putative Replication factor C subunit 5.	0.946
FEN1	VHEMI03809	A0A0A1TDZ2	A0A0A1TBY6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication factor C subunit 1.	0.873