STRINGSTRING
AIM35371.1 AIM35371.1 nadA nadA gmk gmk nadD nadD surE surE purD purD AIM35541.1 AIM35541.1 AIM35741.1 AIM35741.1 AIM35750.1 AIM35750.1 AIM35751.1 AIM35751.1 AIM35753.1 AIM35753.1 purC purC AIM35861.1 AIM35861.1 purK purK purE purE AIM36013.1 AIM36013.1 AIM36063.1 AIM36063.1 thyA thyA pncB pncB AIM36146.1 AIM36146.1 tdk tdk ppnK ppnK asnB asnB AIM36433.1 AIM36433.1 AIM36434.1 AIM36434.1 AIM36459.1 AIM36459.1 apt apt purH purH AIM36566.1 AIM36566.1 carA carA AIM36610.1 AIM36610.1 AIM36633.1 AIM36633.1 guaA guaA AIM36657.1 AIM36657.1 AIM36658.1 AIM36658.1 AIM36806.1 AIM36806.1 AIM36880.1 AIM36880.1 cobB cobB AIM37067.1 AIM37067.1 surE-2 surE-2 AIM37287.1 AIM37287.1 purA purA pyrD pyrD AIM37505.1 AIM37505.1 asnA asnA pyrE pyrE AIM37774.1 AIM37774.1 AIM37775.1 AIM37775.1 AIM37776.1 AIM37776.1 AIM37777.1 AIM37777.1 purN purN guaB guaB AIM37899.1 AIM37899.1 AIM37900.1 AIM37900.1 purL purL AIM37991.1 AIM37991.1 AIM38104.1 AIM38104.1 AIM38384.1 AIM38384.1 pyrG pyrG AIM38497.1 AIM38497.1 AIM38514.1 AIM38514.1 AIM38624.1 AIM38624.1 AIM38625.1 AIM38625.1 pyrB pyrB AIM38633.1 AIM38633.1 nadE nadE AIM38867.1 AIM38867.1 AIM38894.1 AIM38894.1 AIM39130.1 AIM39130.1 AIM39131.1 AIM39131.1 AIM39132.1 AIM39132.1 AIM39234.1 AIM39234.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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AIM35371.1L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (530 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (331 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (189 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (191 aa)
surEStationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (257 aa)
purDPhosphoribosylamine--glycine ligase; Catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (424 aa)
AIM35541.1Arginase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the arginase family. (394 aa)
AIM35741.1Carbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (938 aa)
AIM35750.1NadR; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)
AIM35751.1Nicotinamide mononucleotide transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
AIM35753.1Uracil phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
AIM35861.1Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (191 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (380 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa)
AIM36013.1Damage-inducible protein CinA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CinA family. (420 aa)
AIM36063.1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (164 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (273 aa)
pncBNicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (390 aa)
AIM36146.1Dihydroorotase; Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
tdkThymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
ppnKInorganic polyphosphate kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (295 aa)
asnBFunctions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; Derived by automated computational analysis using gene prediction method: Protein Homology. (562 aa)
AIM36433.1Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (190 aa)
AIM36434.1GCN5 family acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
AIM36459.1Dihydroorotase; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (176 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (508 aa)
AIM36566.1Uridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (366 aa)
AIM36610.1Phosphoribosylformylglycinamidine cyclo-ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (392 aa)
AIM36633.1Orotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (516 aa)
AIM36657.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
AIM36658.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
AIM36806.1Pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
AIM36880.1Aspartate racemase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/glutamate racemases family. (474 aa)
cobBNAD-dependent deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily. (233 aa)
AIM37067.1Aspartate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
surE-25'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (241 aa)
AIM37287.1Nicotinate-nucleotide pyrophosphorylase; Catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family. (284 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (425 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (346 aa)
AIM37505.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa)
asnAAsparagine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (215 aa)
AIM37774.15'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
AIM37775.15'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (319 aa)
AIM37776.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
AIM37777.1Amidophosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (636 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (190 aa)
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (491 aa)
AIM37899.1Thymidylate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
AIM37900.1Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1224 aa)
AIM37991.1Phosphoribosylaminoimidazole-succinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
AIM38104.1Thymidylate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
AIM38384.1Isochorismatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (544 aa)
AIM38497.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (449 aa)
AIM38514.1Phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
AIM38624.11-alkyl-2-acetylglycerophosphocholine esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
AIM38625.1Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. (432 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (312 aa)
AIM38633.1PyrR protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (182 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (546 aa)
AIM38867.1Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa)
AIM38894.1Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (271 aa)
AIM39130.1dCTP deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (207 aa)
AIM39131.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
AIM39132.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (101 aa)
AIM39234.1Deoxycytidine triphosphate deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
Your Current Organism:
Sphingobacterium sp. ML3W
NCBI taxonomy Id: 1538644
Other names: S. sp. ML3W
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