(22 nodes) Helicase superfamily 1/2, ATP-binding domain network (Sphingobacterium sp. ML3W)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AIM38876.1	Helicase SNF2; Derived by automated computational analysis using gene prediction method: Protein Homology. (961 aa)
	recG	ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (701 aa)
	secA	Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (1098 aa)
	mfd	Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1111 aa)
	uvrB	Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (676 aa)
	AIM35903.1	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family. (449 aa)
	AIM36054.1	ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (633 aa)
	AIM36139.1	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family. (634 aa)
	AIM36251.1	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family. (433 aa)
	AIM36378.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1117 aa)
	AIM36497.1	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
	AIM36991.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (840 aa)
	AIM36993.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1088 aa)
	AIM36995.1	Type I restriction endonuclease; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1045 aa)
	AIM37085.1	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (830 aa)
	AIM37464.1	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family. (411 aa)
	AIM37683.1	Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
	AIM37725.1	ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (729 aa)
	AIM37751.1	DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (635 aa)
	AIM38369.1	DEAD/DEAH box helicase; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1003 aa)
	AIM38540.1	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family. (380 aa)
	priA	Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (827 aa)

Your Current Organism:

Sphingobacterium sp. ML3W

NCBI taxonomy Id: 1538644
Other names: S. sp. ML3W

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM35903.1	AIM36054.1	KO02_03800	KO02_04635	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.708
AIM35903.1	AIM36378.1	KO02_03800	KO02_06455	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.426
AIM35903.1	AIM36991.1	KO02_03800	KO02_10000	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.656
AIM35903.1	AIM37725.1	KO02_03800	KO02_14340	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.581
AIM35903.1	AIM38876.1	KO02_03800	KO02_20840	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	Helicase SNF2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.426
AIM36054.1	AIM35903.1	KO02_04635	KO02_03800	ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	0.708
AIM36054.1	AIM36378.1	KO02_04635	KO02_06455	ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.603
AIM36054.1	AIM36497.1	KO02_04635	KO02_07125	ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.655
AIM36054.1	AIM38876.1	KO02_04635	KO02_20840	ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.	Helicase SNF2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.601
AIM36139.1	AIM36378.1	KO02_05080	KO02_06455	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.426
AIM36139.1	AIM36497.1	KO02_05080	KO02_07125	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.929
AIM36139.1	AIM36991.1	KO02_05080	KO02_10000	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.656
AIM36139.1	AIM37683.1	KO02_05080	KO02_14105	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.926
AIM36139.1	AIM38876.1	KO02_05080	KO02_20840	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	Helicase SNF2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.426
AIM36251.1	AIM36378.1	KO02_05730	KO02_06455	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.426
AIM36251.1	AIM36991.1	KO02_05730	KO02_10000	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.656
AIM36251.1	AIM38876.1	KO02_05730	KO02_20840	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	Helicase SNF2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.426
AIM36378.1	AIM35903.1	KO02_06455	KO02_03800	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	0.426
AIM36378.1	AIM36054.1	KO02_06455	KO02_04635	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.603
AIM36378.1	AIM36139.1	KO02_06455	KO02_05080	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	0.426