STRINGSTRING
ADZ25123.1 ADZ25123.1 gyrB gyrB nth nth ADZ25185.1 ADZ25185.1 ADZ25215.1 ADZ25215.1 radA radA ADZ25298.1 ADZ25298.1 ADZ25460.1 ADZ25460.1 ruvC ruvC ruvA ruvA ruvB ruvB ADZ25464.1 ADZ25464.1 ADZ25465.1 ADZ25465.1 ADZ25466.1 ADZ25466.1 ADZ25487.1 ADZ25487.1 ADZ25523.1 ADZ25523.1 mfd mfd uvrA uvrA ADZ25634.1 ADZ25634.1 ADZ25635.1 ADZ25635.1 polA polA gyrA gyrA ADZ26161.1 ADZ26161.1 ADZ26266.1 ADZ26266.1 ADZ26352.1 ADZ26352.1 uvrB uvrB ADZ26484.1 ADZ26484.1 ADZ26485.1 ADZ26485.1 dnaX dnaX ADZ26677.1 ADZ26677.1 hrcA hrcA priA priA ADZ26790.1 ADZ26790.1 ADZ26817.1 ADZ26817.1 ADZ26821.1 ADZ26821.1 ADZ26822.1 ADZ26822.1 ADZ26878.1 ADZ26878.1 ADZ26939.1 ADZ26939.1 ADZ26940.1 ADZ26940.1 ADZ26941.1 ADZ26941.1 ADZ27060.1 ADZ27060.1 ADZ27172.1 ADZ27172.1 uvrC uvrC ADZ27330.1 ADZ27330.1 ADZ27331.1 ADZ27331.1 ADZ27332.1 ADZ27332.1 mutL mutL yacG yacG dnaQ dnaQ rnhA rnhA ADZ27587.1 ADZ27587.1 recX recX recA recA ADZ27777.1 ADZ27777.1 rpoH rpoH dnaG dnaG ADZ27879.1 ADZ27879.1 mutS mutS
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
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ADZ25123.1DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (371 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (806 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (210 aa)
ADZ25185.1HhH-GPD family protein; KEGG: neu:NE0981 HhH-GPD; PFAM: HhH-GPD domain; SMART: HhH-GPD domain; Helix-hairpin-helix DNA-binding motif, class 1. (205 aa)
ADZ25215.1TIGRFAM: DNA polymerase III, delta subunit; KEGG: nmu:Nmul_A0513 DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta. (334 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (449 aa)
ADZ25298.1PHP domain protein; PFAM: PHP, C-terminal; KEGG: tin:Tint_3224 SMC domain protein. (885 aa)
ADZ25460.1Protein of unknown function DUF28; KEGG: nmu:Nmul_A2722 hypothetical protein; TIGRFAM: Protein of unknown function DUF28; PFAM: Protein of unknown function DUF28. (241 aa)
ruvCCrossover junction endodeoxyribonuclease ruvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (172 aa)
ruvAHolliday junction ATP-dependent DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (193 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (348 aa)
ADZ25464.1KEGG: ure:UREG_02430 hypothetical protein. (143 aa)
ADZ25465.1Protein of unknown function UPF0005; PFAM: Inhibitor of apoptosis-promoting Bax1-related; KEGG: net:Neut_1715 hypothetical protein; Belongs to the BI1 family. (223 aa)
ADZ25466.1KEGG: hna:Hneap_0467 hypothetical protein. (59 aa)
ADZ25487.1PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; KEGG: mca:MCA0551 hypothetical protein. (947 aa)
ADZ25523.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (462 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1154 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (939 aa)
ADZ25634.1PFAM: Major facilitator superfamily MFS-1; KEGG: net:Neut_2460 major facilitator transporter. (460 aa)
ADZ25635.1Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (150 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (916 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (852 aa)
ADZ26161.1TIGRFAM: Exodeoxyribonuclease III xth; AP endonuclease, family 1; KEGG: nmu:Nmul_A0224 exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase. (257 aa)
ADZ26266.1PFAM: DNA helicase, UvrD/REP type; KEGG: nmu:Nmul_A0563 UvrD/REP helicase. (738 aa)
ADZ26352.1DNA polymerase III, alpha subunit; SMART: Polymerase/histidinol phosphatase, N-terminal; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: nmu:Nmul_A2731 DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type. (1167 aa)
uvrBUvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (676 aa)
ADZ26484.1HhH-GPD family protein; PFAM: HhH-GPD domain; KEGG: eba:ebA7191 DNA-3-methyladenine glycosidase II. (316 aa)
ADZ26485.1methylated-DNA/protein-cysteine methyltransferase; KEGG: pfl:PFL_3409 ADA regulatory protein; TIGRFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding; PFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding. (177 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (537 aa)
ADZ26677.1DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (559 aa)
hrcAHeat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (339 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (737 aa)
ADZ26790.1KEGG: net:Neut_1339 DNA mismatch repair protein MutS domain-containing protein; PFAM: DNA mismatch repair protein MutS, C-terminal; SMART: DNA mismatch repair protein MutS, C-terminal. (582 aa)
ADZ26817.1TIGRFAM: DNA helicase, ATP-dependent, RecQ type, bacterial; DNA helicase, ATP-dependent, RecQ type; PFAM: RQC domain; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; Helicase/RNase D C-terminal, HRDC domain; KEGG: rme:Rmet_3328 ATP-dependent DNA helicase RecQ; SMART: RQC domain; DEAD-like helicase, N-terminal; Helicase, C-terminal; Helicase/RNase D C-terminal, HRDC domain. (651 aa)
ADZ26821.1TIGRFAM: Exodeoxyribonuclease III xth; AP endonuclease, family 1; KEGG: neu:NE0023 exodeoxyribonuclease III:exodeoxyribonuclease III xth; PFAM: Endonuclease/exonuclease/phosphatase. (261 aa)
ADZ26822.1KEGG: nmu:Nmul_A1412 helicase C2; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; SMART: Helicase, ATP-dependent, c2 type; DEAD-like helicase, N-terminal. (642 aa)
ADZ26878.1KEGG: nhl:Nhal_1339 hypothetical protein. (824 aa)
ADZ26939.1PFAM: Modulator of Rho-dependent transcription termination; KEGG: neu:NE0186 hypothetical protein. (84 aa)
ADZ26940.1A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (357 aa)
ADZ26941.1KEGG: nmu:Nmul_A0079 5-formyltetrahydrofolate cyclo-ligase; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (198 aa)
ADZ27060.1PFAM: DNA polymerase III chi subunit, HolC; KEGG: nmu:Nmul_A0745 DNA polymerase III chi subunit, HolC. (159 aa)
ADZ27172.1TIGRFAM: DNA polymerase III, delta prime subunit; KEGG: nmu:Nmul_A1386 DNA polymerase III, delta prime subunit. (346 aa)
uvrCUvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (605 aa)
ADZ27330.1PFAM: Peptidase S24/S26A/S26B, conserved region; KEGG: mmb:Mmol_0462 peptidase S24 and S26 domain protein; Belongs to the peptidase S24 family. (206 aa)
ADZ27331.1DNA polymerase III, epsilon subunit; SMART: Exonuclease; Excinuclease ABC, C subunit, N-terminal; TIGRFAM: DNA polymerase III, epsilon subunit; KEGG: mei:Msip34_2797 DNA polymerase III, epsilon subunit; PFAM: Exonuclease, RNase T/DNA polymerase III; Excinuclease ABC, C subunit, N-terminal. (463 aa)
ADZ27332.1KEGG: rcu:RCOM_1869020 uv inducible DNA polymerase umuc / mucb, putative; PFAM: DNA-repair protein, UmuC-like. (431 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (597 aa)
yacGUncharacterized zinc-binding family protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. (58 aa)
dnaQDNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (245 aa)
rnhARibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (151 aa)
ADZ27587.1PFAM: Methyltransferase type 11; KEGG: nmu:Nmul_A1620 generic methyl-transferase. (256 aa)
recXRegulatory protein recX; Modulates RecA activity; Belongs to the RecX family. (152 aa)
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (344 aa)
ADZ27777.1SMART: DNA topoisomerase, type IA, DNA-binding; DNA topoisomerase, type IA, domain 2; Toprim domain; TIGRFAM: DNA topoisomerase III, bacterial-type; KEGG: nmu:Nmul_A0396 DNA topoisomerase III; PFAM: DNA topoisomerase, type IA, central; Toprim domain. (838 aa)
rpoHRNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (281 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (599 aa)
ADZ27879.1KEGG: slo:Shew_0457 ATP-dependent helicase HepA; PFAM: RNA polymerase recycling, bacterial, C-terminal; Helicase, C-terminal; SNF2-related; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal. (966 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (865 aa)
Your Current Organism:
Nitrosomonas sp. AL212
NCBI taxonomy Id: 153948
Other names: N. sp. AL212
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