STRINGSTRING
ADZ26280.1 ADZ26280.1 ADZ26279.1 ADZ26279.1 rnr rnr ADZ26163.1 ADZ26163.1 ADZ26161.1 ADZ26161.1 rne rne polA polA ADZ25979.1 ADZ25979.1 rnc rnc ADZ25886.1 ADZ25886.1 ADZ25863.1 ADZ25863.1 ADZ25851.1 ADZ25851.1 ADZ25850.1 ADZ25850.1 ADZ25846.1 ADZ25846.1 ADZ25693.1 ADZ25693.1 uvrA uvrA ADZ25539.1 ADZ25539.1 ADZ25537.1 ADZ25537.1 rph rph ruvC ruvC ybeY ybeY ADZ25442.1 ADZ25442.1 ADZ25381.1 ADZ25381.1 ADZ25380.1 ADZ25380.1 vapC vapC ADZ25376.1 ADZ25376.1 ADZ25320.1 ADZ25320.1 ADZ25314.1 ADZ25314.1 ADZ25313.1 ADZ25313.1 ADZ25281.1 ADZ25281.1 cas1 cas1 ADZ25183.1 ADZ25183.1 ADZ25123.1 ADZ25123.1 ADZ26352.1 ADZ26352.1 ADZ26311.1 ADZ26311.1 ADZ26314.1 ADZ26314.1 ADZ26316.1 ADZ26316.1 ADZ26321.1 ADZ26321.1 cas2 cas2 cas1-2 cas1-2 ADZ26346.1 ADZ26346.1 ADZ26350.1 ADZ26350.1 ADZ27929.1 ADZ27929.1 ADZ27923.1 ADZ27923.1 rnhB rnhB ADZ27812.1 ADZ27812.1 orn orn ADZ27762.1 ADZ27762.1 cas9 cas9 cas2-2 cas2-2 ADZ27712.1 ADZ27712.1 ADZ27685.1 ADZ27685.1 rnhA rnhA dnaQ dnaQ xseA xseA rnpA rnpA xseB xseB ADZ27452.1 ADZ27452.1 ADZ27441.1 ADZ27441.1 ADZ27398.1 ADZ27398.1 ADZ27397.1 ADZ27397.1 ADZ27379.1 ADZ27379.1 ADZ27368.1 ADZ27368.1 ADZ27336.1 ADZ27336.1 ADZ27331.1 ADZ27331.1 uvrC uvrC ADZ27306.1 ADZ27306.1 ADZ27292.1 ADZ27292.1 ADZ27281.1 ADZ27281.1 vapC-2 vapC-2 ADZ27262.1 ADZ27262.1 ADZ27132.1 ADZ27132.1 ADZ27093.1 ADZ27093.1 ADZ27090.1 ADZ27090.1 ADZ27074.1 ADZ27074.1 ADZ26821.1 ADZ26821.1 ADZ26810.1 ADZ26810.1 ADZ26722.1 ADZ26722.1 ADZ26688.1 ADZ26688.1 ADZ26515.1 ADZ26515.1 ADZ26467.1 ADZ26467.1 uvrB uvrB ADZ26400.1 ADZ26400.1 ADZ26389.1 ADZ26389.1 ADZ26383.1 ADZ26383.1 ADZ26364.1 ADZ26364.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADZ26280.1PFAM: DNA helicase, UvrD/REP type; KEGG: nmu:Nmul_A0723 UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (1158 aa)
ADZ26279.1TIGRFAM: DNA repair protein, predicted; KEGG: nmu:Nmul_A0722 hypothetical protein. (923 aa)
rnrRibonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (741 aa)
ADZ26163.1KEGG: gpb:HDN1F_07110 hypothetical protein. (259 aa)
ADZ26161.1TIGRFAM: Exodeoxyribonuclease III xth; AP endonuclease, family 1; KEGG: nmu:Nmul_A0224 exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase. (257 aa)
rneRibonuclease, Rne/Rng family; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (837 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (916 aa)
ADZ25979.1PFAM: IstB-like ATP-binding protein; Integrase, catalytic core; KEGG: mms:mma_2809 transposase IstA. (664 aa)
rncRibonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (237 aa)
ADZ25886.1KEGG: nmi:NMO_1071 hypothetical protein. (204 aa)
ADZ25863.1PFAM: Ribonuclease T2; KEGG: nhl:Nhal_0810 ribonuclease T2; Belongs to the RNase T2 family. (338 aa)
ADZ25851.1KEGG: gur:Gura_1482 hypothetical protein; PFAM: Restriction endonuclease, type I, EcoRI, R subunit/Type III, Res subunit, N-terminal; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: DEAD-like helicase, N-terminal. (1103 aa)
ADZ25850.1PFAM: Protein of unknown function DUF86; KEGG: mmw:Mmwyl1_1312 hypothetical protein. (146 aa)
ADZ25846.1PFAM: Excinuclease ABC, C subunit, N-terminal; KEGG: cpc:Cpar_1954 excinuclease ABC C subunit domain protein. (95 aa)
ADZ25693.1Holliday junction resolvase YqgF; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (161 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (939 aa)
ADZ25539.1PFAM: Integrase, catalytic core; Resolvase, helix-turn-helix domain; KEGG: pst:PSPTO_B0040 ISPsy4, transposase. (340 aa)
ADZ25537.1KEGG: neu:NE1584 hypothetical protein; TIGRFAM: Addiction module toxin, RelE/StbE; PFAM: Plasmid stabilisation system. (98 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (240 aa)
ruvCCrossover junction endodeoxyribonuclease ruvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (172 aa)
ybeYProtein of unknown function UPF0054; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (168 aa)
ADZ25442.1KEGG: net:Neut_0131 single-stranded-DNA-specific exonuclease RecJ; TIGRFAM: Bacterial RecJ exonuclease; PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1. (590 aa)
ADZ25381.1Type I site-specific deoxyribonuclease, HsdR family; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1079 aa)
ADZ25380.1KEGG: cag:Cagg_2602 excinuclease ABC C subunit domain protein; PFAM: Excinuclease ABC, C subunit, N-terminal; SMART: Excinuclease ABC, C subunit, N-terminal. (110 aa)
vapCPilT protein domain protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (140 aa)
ADZ25376.1PFAM: Restriction endonuclease, type I, S subunit, EcoBI; KEGG: ava:Ava_3499 restriction modification system DNA specificity subunit. (428 aa)
ADZ25320.1PFAM: Replication endonuclease, probable, phage; KEGG: mfa:Mfla_0975 bacteriophage replication gene A. (562 aa)
ADZ25314.1PFAM: Plasmid stabilisation system; KEGG: bgl:bglu_1g12000 hypothetical protein. (88 aa)
ADZ25313.1PFAM: Integrase, catalytic core; Resolvase, helix-turn-helix domain; KEGG: pst:PSPTO_B0040 ISPsy4, transposase. (340 aa)
ADZ25281.1KEGG: mes:Meso_3789 relaxase/mobilization nuclease domain-containing protein. (432 aa)
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (430 aa)
ADZ25183.1PFAM: Restriction endonuclease, type I, EcoEI, R subunit/Type III, Res subunit, C-terminal; Restriction endonuclease, type I, R subunit/Type III, Res subunit; Restriction endonuclease, type I, EcoRI, R subunit/Type III, Res subunit, N-terminal; KEGG: gca:Galf_0381 type I site-specific deoxyribonuclease; SMART: DEAD-like helicase, N-terminal. (787 aa)
ADZ25123.1DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (371 aa)
ADZ26352.1DNA polymerase III, alpha subunit; SMART: Polymerase/histidinol phosphatase, N-terminal; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: nmu:Nmul_A2731 DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type. (1167 aa)
ADZ26311.1PFAM: Integrase, catalytic core; KEGG: mms:mma_2809 transposase IstA. (499 aa)
ADZ26314.1KEGG: pst:PSPTO_4627 hypothetical protein. (831 aa)
ADZ26316.1PFAM: Protein of unknown function DUF2136; KEGG: neu:NE1588 hypothetical protein. (100 aa)
ADZ26321.1PFAM: Replication endonuclease, probable, phage; KEGG: mfa:Mfla_0975 bacteriophage replication gene A. (541 aa)
cas2CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (95 aa)
cas1-2CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (344 aa)
ADZ26346.1CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (211 aa)
ADZ26350.1KEGG: mfa:Mfla_0602 CRISPR-associated Cas5d family protein; TIGRFAM: CRISPR-associated protein, Cas5d-type; CRISPR-associated protein Cas5, N-terminal domain; PFAM: CRISPR-associated protein, Cas5. (227 aa)
ADZ27929.1Type I site-specific deoxyribonuclease, HsdR family; TIGRFAM: Restriction endonuclease, type I, EcoRI, R subunit; PFAM: Type I restriction and modification enzyme, subunit R, C-terminal; Restriction endonuclease, type I, R subunit/Type III, Res subunit; Transposase IS200-like; Restriction endonuclease, type I, EcoRI, R subunit/Type III, Res subunit, N-terminal; KEGG: pph:Ppha_0743 type I site-specific deoxyribonuclease, HsdR family; SMART: DEAD-like helicase, N-terminal. (1206 aa)
ADZ27923.1PFAM: Integrase, catalytic core; Resolvase, helix-turn-helix domain; KEGG: pst:PSPTO_B0040 ISPsy4, transposase. (340 aa)
rnhBRibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (190 aa)
ADZ27812.1PFAM: IstB-like ATP-binding protein; Integrase, catalytic core; KEGG: mms:mma_2809 transposase IstA. (626 aa)
ornExonuclease RNase T and DNA polymerase III; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family. (181 aa)
ADZ27762.1KEGG: nmu:Nmul_A0024 Smr protein/MutS2-like; PFAM: Smr protein/MutS2 C-terminal; SMART: Smr protein/MutS2 C-terminal. (175 aa)
cas9CRISPR-associated protein, Csn1 family; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans- encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this [...] (1044 aa)
cas2-2CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (101 aa)
ADZ27712.1KEGG: net:Neut_1887 exonuclease I; PFAM: Exonuclease C-terminal; Exonuclease, RNase T/DNA polymerase III. (478 aa)
ADZ27685.1PFAM: General secretion pathway, GspH; Prepilin-type cleavage/methylation, N-terminal; KEGG: neu:NE1751 putative type-4 fimbrial pilin related signal peptide protein. (192 aa)
rnhARibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (151 aa)
dnaQDNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (245 aa)
xseAExodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (450 aa)
rnpARibonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (128 aa)
xseBExodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (84 aa)
ADZ27452.1PFAM: Integrase, catalytic core; KEGG: pst:PSPTO_B0040 ISPsy4, transposase. (304 aa)
ADZ27441.1PFAM: Integrase, catalytic core; KEGG: mms:mma_2809 transposase IstA. (499 aa)
ADZ27398.1PFAM: Integrase, catalytic core; KEGG: swi:Swit_4958 transposase. (509 aa)
ADZ27397.1KEGG: nmu:Nmul_A2395 hypothetical protein. (215 aa)
ADZ27379.1KEGG: net:Neut_0850 nuclease; PFAM: Staphylococcal nuclease (SNase-like); SMART: Staphylococcal nuclease (SNase-like). (283 aa)
ADZ27368.1KEGG: lpa:lpa_00291 hypothetical protein; PFAM: Staphylococcal nuclease (SNase-like); SMART: Staphylococcal nuclease (SNase-like). (137 aa)
ADZ27336.1PFAM: Integrase, catalytic core; KEGG: swi:Swit_4958 transposase. (509 aa)
ADZ27331.1DNA polymerase III, epsilon subunit; SMART: Exonuclease; Excinuclease ABC, C subunit, N-terminal; TIGRFAM: DNA polymerase III, epsilon subunit; KEGG: mei:Msip34_2797 DNA polymerase III, epsilon subunit; PFAM: Exonuclease, RNase T/DNA polymerase III; Excinuclease ABC, C subunit, N-terminal. (463 aa)
uvrCUvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (605 aa)
ADZ27306.1PFAM: Plasmid stabilisation system; KEGG: nhl:Nhal_1008 phage protein. (85 aa)
ADZ27292.1Ribonuclease II; KEGG: net:Neut_0498 ribonuclease II; PFAM: Ribonuclease II/R; SMART: Ribonuclease II/R. (618 aa)
ADZ27281.1PFAM: Integrase, catalytic core; Resolvase, helix-turn-helix domain; KEGG: pst:PSPTO_B0040 ISPsy4, transposase. (340 aa)
vapC-2PilT protein domain protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (139 aa)
ADZ27262.1KEGG: noc:Noc_0284 hypothetical protein. (104 aa)
ADZ27132.1KEGG: nmu:Nmul_A0065 hypothetical protein; TIGRFAM: Conserved hypothetical protein CHP00255; PFAM: YicC-like, N-terminal; Domain of unknown function DUF1732. (288 aa)
ADZ27093.1PFAM: Domain of unknown function DUF88; KEGG: neu:NE0665 hypothetical protein. (292 aa)
ADZ27090.1PFAM: PilT protein, N-terminal; KEGG: sjp:SJA_C1-29410 putative nucleic-acid-binding protein. (124 aa)
ADZ27074.1PFAM: Integrase, catalytic core; KEGG: swi:Swit_4958 transposase. (509 aa)
ADZ26821.1TIGRFAM: Exodeoxyribonuclease III xth; AP endonuclease, family 1; KEGG: neu:NE0023 exodeoxyribonuclease III:exodeoxyribonuclease III xth; PFAM: Endonuclease/exonuclease/phosphatase. (261 aa)
ADZ26810.1PFAM: Integrase, catalytic core; Resolvase, helix-turn-helix domain; KEGG: pst:PSPTO_B0040 ISPsy4, transposase. (340 aa)
ADZ26722.1Beta-Casp domain; KEGG: neu:NE0025 metallo-beta-lactamase superfamily protein; PFAM: Beta-Casp domain; RNA-metabolising metallo-beta-lactamase; Beta-lactamase-like; SMART: Beta-lactamase-like. (465 aa)
ADZ26688.1KEGG: nmu:Nmul_A0913 hypothetical protein. (319 aa)
ADZ26515.1PFAM: Integrase, catalytic core; KEGG: mms:mma_2809 transposase IstA. (499 aa)
ADZ26467.1Ribonuclease, Rne/Rng family; TIGRFAM: Ribonuclease E/G; PFAM: RNA-binding protein AU-1/Ribonuclease E/G; Ribosomal protein S1, RNA-binding domain; KEGG: net:Neut_1614 ribonuclease, Rne/Rng family protein; SMART: RNA-binding domain, S1. (484 aa)
uvrBUvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (676 aa)
ADZ26400.1Hydrolase, TatD family; KEGG: neu:NE1516 hypothetical protein; TIGRFAM: Deoxyribonuclease, TatD Mg-dependent, prokaryote; PFAM: Deoxyribonuclease, TatD-related. (260 aa)
ADZ26389.1PFAM: Integrase, catalytic core; Resolvase, helix-turn-helix domain; KEGG: pst:PSPTO_B0040 ISPsy4, transposase. (340 aa)
ADZ26383.1PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; KEGG: rce:RC1_0095 type III restriction enzyme, res subunit, putative. (895 aa)
ADZ26364.1KEGG: slt:Slit_2774 HNH endonuclease; PFAM: HNH endonuclease; SMART: HNH nuclease. (119 aa)
Your Current Organism:
Nitrosomonas sp. AL212
NCBI taxonomy Id: 153948
Other names: N. sp. AL212
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