STRINGSTRING
thiL thiL panC panC panB panB ADZ27951.1 ADZ27951.1 thiC thiC ADZ27691.1 ADZ27691.1 ADZ27686.1 ADZ27686.1 dxs dxs ADZ27364.1 ADZ27364.1 ADZ27171.1 ADZ27171.1 ADZ27110.1 ADZ27110.1 cysG cysG ADZ26912.1 ADZ26912.1 ADZ26874.1 ADZ26874.1 ADZ26721.1 ADZ26721.1 ADZ26660.1 ADZ26660.1 ADZ26448.1 ADZ26448.1 ADZ26396.1 ADZ26396.1 ADZ26295.1 ADZ26295.1 thiG thiG bioD bioD bioC bioC bioH bioH bioF bioF bioB bioB serC serC ADZ26033.1 ADZ26033.1 pdxJ pdxJ ADZ25901.1 ADZ25901.1 pdxA pdxA ADZ25673.1 ADZ25673.1 ADZ25573.1 ADZ25573.1 thiE thiE ADZ25497.1 ADZ25497.1 ribH ribH ribB ribB ADZ25407.1 ADZ25407.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (323 aa)
panCPantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (274 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (263 aa)
ADZ27951.1TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: nmu:Nmul_A0881 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (162 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (631 aa)
ADZ27691.1Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (366 aa)
ADZ27686.1TIGRFAM: Glycine oxidase ThiO; KEGG: neu:NE0650 NAD binding site:D-amino acid oxidase; PFAM: FAD dependent oxidoreductase. (368 aa)
dxsDeoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (614 aa)
ADZ27364.1PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: mem:Memar_2271 glyoxalase/bleomycin resistance protein/dioxygenase. (138 aa)
ADZ27171.1PFAM: Domain of unknown function DUF336; KEGG: noc:Noc_2147 hypothetical protein. (173 aa)
ADZ27110.1Riboflavin biosynthesis protein RibF; SMART: Riboflavin kinase; TIGRFAM: Riboflavin kinase/FAD synthetase; KEGG: nmu:Nmul_A2653 riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; Belongs to the ribF family. (322 aa)
cysGuroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (465 aa)
ADZ26912.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (277 aa)
ADZ26874.1PFAM: NUDIX hydrolase domain; KEGG: neu:NE2253 dATP pyrophosphohydrolase. (151 aa)
ADZ26721.1TIGRFAM: Adenosylmethionine--8-amino-7-oxononanoate aminotransferase; KEGG: nmu:Nmul_A2364 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa)
ADZ26660.1PFAM: Ketopantoate reductase ApbA/PanE, C-terminal; Ketopantoate reductase ApbA/PanE, N-terminal; KEGG: vdi:Vdis_0590 2-dehydropantoate 2-reductase. (340 aa)
ADZ26448.1cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (201 aa)
ADZ26396.1KEGG: neu:NE0456 esterase/lipase/thioesterase family protein. (302 aa)
ADZ26295.1KEGG: net:Neut_0324 thiamine biosynthesis protein ThiS; TIGRFAM: ThiS, thiamine-biosynthesis; PFAM: ThiamineS. (67 aa)
thiGThiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (271 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (227 aa)
bioCBiotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (293 aa)
bioHbioH protein; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. (256 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (388 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (336 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (363 aa)
ADZ26033.1Phosphoglycerate dehydrogenase; KEGG: nmu:Nmul_A2191 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (398 aa)
pdxJPyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (241 aa)
ADZ25901.1FolC bifunctional protein; TIGRFAM: Folylpolyglutamate synthetase; KEGG: nmu:Nmul_A1909 FolC bifunctional protein; PFAM: Mur ligase, central; Mur ligase, C-terminal; Belongs to the folylpolyglutamate synthase family. (432 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (336 aa)
ADZ25673.1Phosphoglycerate dehydrogenase; KEGG: net:Neut_0433 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (309 aa)
ADZ25573.1PFAM: Domain of unknown function DUF336; KEGG: nmu:Nmul_A0738 hypothetical protein. (135 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (210 aa)
ADZ25497.1KEGG: nmu:Nmul_A2627 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (285 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (160 aa)
ribB3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (366 aa)
ADZ25407.1Riboflavin synthase, alpha subunit; TIGRFAM: Lumazine-binding protein; KEGG: nmu:Nmul_A0009 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein. (199 aa)
Your Current Organism:
Nitrosomonas sp. AL212
NCBI taxonomy Id: 153948
Other names: N. sp. AL212
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