STRINGSTRING
ADZ27879.1 ADZ27879.1 ADZ27777.1 ADZ27777.1 cas9 cas9 cas2-2 cas2-2 ADZ26984.1 ADZ26984.1 ADZ26902.1 ADZ26902.1 ADZ26897.1 ADZ26897.1 ADZ26817.1 ADZ26817.1 priA priA recG recG ADZ26517.1 ADZ26517.1 ADZ26497.1 ADZ26497.1 ADZ26391.1 ADZ26391.1 ADZ26350.1 ADZ26350.1 ADZ26348.1 ADZ26348.1 cas1-2 cas1-2 cas2 cas2 ADZ26280.1 ADZ26280.1 ADZ26266.1 ADZ26266.1 ADZ26238.1 ADZ26238.1 ADZ26171.1 ADZ26171.1 ADZ26114.1 ADZ26114.1 gyrA gyrA smc smc gyrB gyrB ADZ25967.1 ADZ25967.1 mfd mfd ADZ25523.1 ADZ25523.1 ruvB ruvB ruvA ruvA ADZ25418.1 ADZ25418.1 ADZ25281.1 ADZ25281.1 cas1 cas1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADZ27879.1KEGG: slo:Shew_0457 ATP-dependent helicase HepA; PFAM: RNA polymerase recycling, bacterial, C-terminal; Helicase, C-terminal; SNF2-related; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal. (966 aa)
ADZ27777.1SMART: DNA topoisomerase, type IA, DNA-binding; DNA topoisomerase, type IA, domain 2; Toprim domain; TIGRFAM: DNA topoisomerase III, bacterial-type; KEGG: nmu:Nmul_A0396 DNA topoisomerase III; PFAM: DNA topoisomerase, type IA, central; Toprim domain. (838 aa)
cas9CRISPR-associated protein, Csn1 family; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans- encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this [...] (1044 aa)
cas2-2CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (101 aa)
ADZ26984.1Histone family protein DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
ADZ26902.1KEGG: slo:Shew_3054 hypothetical protein. (159 aa)
ADZ26897.1KEGG: nhl:Nhal_4024 helicase domain protein; PFAM: Helicase, C-terminal; SNF2-related; SMART: Helicase, C-terminal; DEAD-like helicase, N-terminal. (934 aa)
ADZ26817.1TIGRFAM: DNA helicase, ATP-dependent, RecQ type, bacterial; DNA helicase, ATP-dependent, RecQ type; PFAM: RQC domain; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; Helicase/RNase D C-terminal, HRDC domain; KEGG: rme:Rmet_3328 ATP-dependent DNA helicase RecQ; SMART: RQC domain; DEAD-like helicase, N-terminal; Helicase, C-terminal; Helicase/RNase D C-terminal, HRDC domain. (651 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (737 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (679 aa)
ADZ26517.1KEGG: sbl:Sbal_0637 hypothetical protein. (181 aa)
ADZ26497.1TIGRFAM: RecB family nuclease, TM0106, putative; KEGG: cyc:PCC7424_0336 hypothetical protein. (489 aa)
ADZ26391.1SNF2-related protein; KEGG: rce:RC1_0099 helicase, SNF2 family, putative; PFAM: SNF2-related; Helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal. (951 aa)
ADZ26350.1KEGG: mfa:Mfla_0602 CRISPR-associated Cas5d family protein; TIGRFAM: CRISPR-associated protein, Cas5d-type; CRISPR-associated protein Cas5, N-terminal domain; PFAM: CRISPR-associated protein, Cas5. (227 aa)
ADZ26348.1KEGG: mfa:Mfla_0604 CRISPR-associated Csh2 family protein; TIGRFAM: CRISPR-associated protein Csd2; CRISPR-associated protein TM1801; PFAM: CRISPR-associated protein TM1801. (291 aa)
cas1-2CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (344 aa)
cas2CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (95 aa)
ADZ26280.1PFAM: DNA helicase, UvrD/REP type; KEGG: nmu:Nmul_A0723 UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (1158 aa)
ADZ26266.1PFAM: DNA helicase, UvrD/REP type; KEGG: nmu:Nmul_A0563 UvrD/REP helicase. (738 aa)
ADZ26238.1PFAM: Protein of unknown function DUF853, nucleotide triphosphate hydrolase, putative; KEGG: pol:Bpro_1966 protein of unknown function DUF853, NPT hydrolase putative. (505 aa)
ADZ26171.1KEGG: gpb:HDN1F_07060 DEAD/DEAH box helicase; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; SMART: DEAD-like helicase, N-terminal. (573 aa)
ADZ26114.1Mg chelatase, subunit ChlI; TIGRFAM: Mg chelatase-related protein; PFAM: Magnesium chelatase, ChlI subunit; KEGG: net:Neut_2377 Mg chelatase, subunit ChlI; SMART: ATPase, AAA+ type, core. (501 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (852 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1183 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (806 aa)
ADZ25967.1PFAM: Domain of unknown function DUF87; KEGG: tmz:Tmz1t_0482 protein of unknown function DUF87. (577 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1154 aa)
ADZ25523.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (462 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (348 aa)
ruvAHolliday junction ATP-dependent DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (193 aa)
ADZ25418.1KEGG: neu:NE0458 hypothetical protein. (642 aa)
ADZ25281.1KEGG: mes:Meso_3789 relaxase/mobilization nuclease domain-containing protein. (432 aa)
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (430 aa)
Your Current Organism:
Nitrosomonas sp. AL212
NCBI taxonomy Id: 153948
Other names: N. sp. AL212
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