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lpxH lpxH rfaE1 rfaE1 KX01_1109 KX01_1109 galE galE kdsA kdsA galU galU KX01_1329 KX01_1329 KX01_1436 KX01_1436 KX01_1437 KX01_1437 galT galT galK galK KX01_1440 KX01_1440 KX01_1442 KX01_1442 kdsB kdsB truA truA KX01_1516 KX01_1516 KX01_1517 KX01_1517 lptB lptB KX01_1519 KX01_1519 lptC lptC KX01_1521 KX01_1521 KX01_1541 KX01_1541 KX01_1543 KX01_1543 KX01_1738 KX01_1738 KX01_1739 KX01_1739 KX01_1741 KX01_1741 KX01_1742 KX01_1742 KX01_1743 KX01_1743 KX01_1744 KX01_1744 KX01_1745 KX01_1745 neuC neuC neuB neuB KX01_1748 KX01_1748 KX01_1749 KX01_1749 KX01_1750 KX01_1750 wecE wecE KX01_1752 KX01_1752 KX01_1753 KX01_1753 KX01_1754 KX01_1754 rfbB rfbB rfbA rfbA KX01_1758 KX01_1758 KX01_1759 KX01_1759 capF capF KX01_1761 KX01_1761 KX01_1763 KX01_1763 KX01_1764 KX01_1764 KX01_1765 KX01_1765 KX01_1767 KX01_1767 arsC-2 arsC-2 KX01_1839 KX01_1839 lptG lptG waaC waaC KX01_240 KX01_240 KX01_241 KX01_241 KX01_268 KX01_268 KX01_327 KX01_327 gmhA gmhA KX01_418 KX01_418 KX01_419 KX01_419 waaF waaF lpxC lpxC lpxK lpxK lpxD lpxD lpxA lpxA lpxB lpxB KX01_795 KX01_795 KX01_891 KX01_891
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lpxHUDP-2,3-diacylglucosamine diphosphatase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (235 aa)
rfaE1Bifunctional protein RfaE, domain I; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (471 aa)
KX01_1109kpsF: sugar isomerase, KpsF/GutQ family protein. (323 aa)
galEgalE: UDP-glucose 4-epimerase GalE; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (339 aa)
kdsAKDO8P_synth: 3-deoxy-8-phosphooctulonate synthase; Belongs to the KdsA family. (275 aa)
galUgalU: UTP--glucose-1-phosphate uridylyltransferase. (289 aa)
KX01_1329Dolichyl-phosphate-mannose-mannosyltransferase family protein. (571 aa)
KX01_1436PPIC-type PPIASE domain protein. (92 aa)
KX01_1437SP: MFS transporter, sugar porter family protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (462 aa)
galTgalT_1: galactose-1-phosphate uridylyltransferase. (345 aa)
galKGal_kin: galactokinase; Belongs to the GHMP kinase family. GalK subfamily. (384 aa)
KX01_1440Hypothetical protein. (228 aa)
KX01_1442ompA-like transmembrane domain protein. (208 aa)
kdsB3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (250 aa)
truAtRNA pseudouridine(38-40) synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (260 aa)
KX01_1516Phosphorylase superfamily protein. (610 aa)
KX01_1517Fumarylacetoacetate (FAA) hydrolase family protein. (198 aa)
lptBLPS_export_lptB: LPS export ABC transporter ATP-binding protein. (244 aa)
KX01_1519ostA-like family protein. (262 aa)
lptClptC_YrbK: LPS export ABC transporter periplasmic protein LptC. (203 aa)
KX01_15213-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family protein; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (185 aa)
KX01_1541Putative membrane protein. (251 aa)
KX01_1543Dolichyl-phosphate-mannose-mannosyltransferase family protein. (600 aa)
KX01_1738Hypothetical protein. (380 aa)
KX01_1739Polysaccharide biosynthesis family protein. (420 aa)
KX01_1741Putative membrane protein. (440 aa)
KX01_1742Short chain dehydrogenase family protein. (256 aa)
KX01_1743Cytidylyltransferase family protein. (234 aa)
KX01_1744Oxidoreductase, NAD-binding Rossmann fold family protein. (302 aa)
KX01_1745Nucleotidyl transferase family protein. (348 aa)
neuCneuC_NnaA: UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing. (385 aa)
neuBneuB_NnaB: N-acetylneuraminate synthase. (333 aa)
KX01_1748neuD_NnaD: sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family protein. (192 aa)
KX01_1749degT/DnrJ/EryC1/StrS aminotransferase family protein; Belongs to the DegT/DnrJ/EryC1 family. (381 aa)
KX01_1750Putative membrane protein. (523 aa)
wecEECA_wecE: TDP-4-keto-6-deoxy-D-glucose transaminase family protein; Belongs to the DegT/DnrJ/EryC1 family. (376 aa)
KX01_1752Putative membrane protein. (382 aa)
KX01_1753gtrA-like family protein. (128 aa)
KX01_1754Glycosyl transferase 2 family protein. (305 aa)
rfbBdTDP_gluc_dehyt: dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (333 aa)
rfbAGlucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (294 aa)
KX01_1758UDP-N-acetylglucosamine 4,6-dehydratase. (396 aa)
KX01_1759wecB: UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (369 aa)
capFCapsular polysaccharide synthesis enzyme Cap5F. (364 aa)
KX01_17613-beta hydroxysteroid dehydrogenase/isomerase family protein. (334 aa)
KX01_17633-beta hydroxysteroid dehydrogenase/isomerase family protein. (263 aa)
KX01_1764Bacterial sugar transferase family protein. (205 aa)
KX01_17653-beta hydroxysteroid dehydrogenase/isomerase family protein. (580 aa)
KX01_1767Hypothetical protein. (249 aa)
arsC-2arsC: arsenate reductase. (115 aa)
KX01_1839Putative permease YjgP/YjgQ family protein. (359 aa)
lptGlptG_lptG: LPS export ABC transporter permease LptG. (348 aa)
waaCheptsyl_trn_I: lipopolysaccharide heptosyltransferase I. (320 aa)
KX01_240Bacterial lipid A biosynthesis acyltransferase family protein. (305 aa)
KX01_241Bacterial lipid A biosynthesis acyltransferase family protein. (301 aa)
KX01_268HAD-SF-IIIA: HAD hydrolase, family IIIA domain protein. (188 aa)
KX01_327Bacterial lipid A biosynthesis acyltransferase family protein. (300 aa)
gmhAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (198 aa)
KX01_418O-Antigen ligase family protein. (401 aa)
KX01_419Glycosyltransferase like 2 family protein. (509 aa)
waaFheptsyl_trn_II: lipopolysaccharide heptosyltransferase II. (340 aa)
lpxCUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (286 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (333 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (338 aa)
lpxAacyl-[acyl-carrier-protein]-UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (258 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (381 aa)
KX01_7953-Deoxy-D-manno-octulosonic-acid transferase family protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (431 aa)
KX01_891Glycosyltransferase like 2 family protein. (326 aa)
Your Current Organism:
Francisella frigiditurris
NCBI taxonomy Id: 1542390
Other names: F. frigiditurris
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