(19 nodes) Helicase superfamily 1/2, ATP-binding domain network (Bacillus weihaiensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APH05086.1	Helicase SNF; Derived by automated computational analysis using gene prediction method: Protein Homology. (1034 aa)
	dbpA	RNA helicase; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes. (481 aa)
	mfd	Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1176 aa)
	cshA	DEAD/DEAH box helicase; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (503 aa)
	APH06264.1	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
	APH05424.1	ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (710 aa)
	priA	Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (804 aa)
	recG	ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (682 aa)
	APH03438.1	ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (920 aa)
	APH03570.1	Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (497 aa)
	secA	Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (836 aa)
	uvrB	Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (661 aa)
	cshB	DEAD/DEAH box helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (438 aa)
	APH04417.1	ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (561 aa)
	APH04566.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (496 aa)
	dinG	ATP-dependent helicase DinG; 3'-5' exonuclease. (939 aa)
	APH04651.1	ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (763 aa)
	APH05046.1	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (833 aa)
	APH07049.1	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)

Your Current Organism:

Bacillus weihaiensis

NCBI taxonomy Id: 1547283
Other names: B. weihaiensis, Bacillus sp. Alg07, strain Alg07

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APH03438.1	APH04566.1	A9C19_00960	A9C19_07305	ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.533
APH03438.1	APH05424.1	A9C19_00960	A9C19_12055	ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.499
APH03438.1	cshA	A9C19_00960	A9C19_18705	ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DEAD/DEAH box helicase; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily.	0.460
APH03438.1	cshB	A9C19_00960	A9C19_06135	ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DEAD/DEAH box helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures.	0.453
APH04417.1	APH04566.1	A9C19_06455	A9C19_07305	ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.494
APH04417.1	APH05424.1	A9C19_06455	A9C19_12055	ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.472
APH04417.1	cshA	A9C19_06455	A9C19_18705	ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DEAD/DEAH box helicase; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily.	0.455
APH04566.1	APH03438.1	A9C19_07305	A9C19_00960	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.533
APH04566.1	APH04417.1	A9C19_07305	A9C19_06455	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.494
APH04566.1	APH05086.1	A9C19_07305	A9C19_10175	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Helicase SNF; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.522
APH04566.1	APH05424.1	A9C19_07305	A9C19_12055	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.519
APH04566.1	dinG	A9C19_07305	A9C19_07650	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent helicase DinG; 3'-5' exonuclease.	0.466
APH04566.1	recG	A9C19_07305	A9C19_11290	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily.	0.414
APH05046.1	APH06264.1	A9C19_09960	A9C19_16870	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.472
APH05046.1	APH07049.1	A9C19_09960	A9C19_10380	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.472
APH05046.1	cshA	A9C19_09960	A9C19_18705	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DEAD/DEAH box helicase; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily.	0.472
APH05046.1	cshB	A9C19_09960	A9C19_06135	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DEAD/DEAH box helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures.	0.472
APH05046.1	dbpA	A9C19_09960	A9C19_20230	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	RNA helicase; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes.	0.472
APH05086.1	APH04566.1	A9C19_10175	A9C19_07305	Helicase SNF; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.522
APH05086.1	APH05424.1	A9C19_10175	A9C19_12055	Helicase SNF; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.508