(44 nodes) Mixed, incl. Valine, leucine and isoleucine degradation, and Benzoate degradation network (Sphingomonas taxi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AIT05191.1	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (772 aa)
	AIT05192.1	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (378 aa)
	AIT07891.1	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (551 aa)
	AIT05717.1	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (394 aa)
	AIT05897.1	Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
	AIT05898.1	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (670 aa)
	AIT05899.1	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
	AIT05900.1	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
	AIT05901.1	acyl-CoA thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
	AIT05902.1	Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
	AIT05903.1	Aminoglycoside phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
	AIT05905.1	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (420 aa)
	AIT05906.1	TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa)
	AIT05907.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
	AIT05922.1	LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (293 aa)
	AIT05923.1	isovaleryl-CoA dehydrogenase; Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
	AIT05924.1	methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (531 aa)
	AIT08008.1	methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (615 aa)
	AIT05925.1	Dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
	AIT06159.1	Nodulation protein NodN; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa)
	AIT06160.1	acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
	AIT06178.1	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
	AIT08126.1	enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
	AIT06610.1	enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
	AIT06611.1	enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
	AIT06703.1	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
	AIT08168.1	NADPH:quinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
	AIT06748.1	succinyl-CoA:3-ketoacid-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
	AIT06751.1	succinyl-CoA:3-ketoacid-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
	AIT06790.1	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
	AIT06833.1	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
	AIT06989.1	3-oxoacyl-ACP reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (300 aa)
	AIT07111.1	Methylmalonate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (509 aa)
	AIT07112.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
	AIT08228.1	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
	AIT07113.1	3-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HIBADH-related family. (290 aa)
	AIT07221.1	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
	AIT07222.1	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
	AIT07282.1	acetoacetyl-CoA reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)
	AIT08261.1	3-hydroxybutyryl-CoA dehydrogenase; Converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
	AIT07706.1	3-oxoacid CoA-transferase; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family. (464 aa)
	AIT07725.1	Catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
	AIT07726.1	3-oxoadipate CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
	AIT07727.1	3-oxoadipate CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)

Your Current Organism:

Sphingomonas taxi

NCBI taxonomy Id: 1549858
Other names: ATCC 55669, Erwinia taxi, S. taxi, strain STJ.EPI.H7

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIT05191.1	AIT05192.1	MC45_00690	MC45_00695	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family.	0.999
AIT05191.1	AIT05717.1	MC45_00690	MC45_04085	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.858
AIT05191.1	AIT05898.1	MC45_00690	MC45_05165	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family.	0.951
AIT05191.1	AIT05899.1	MC45_00690	MC45_05170	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.858
AIT05191.1	AIT05900.1	MC45_00690	MC45_05175	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.858
AIT05191.1	AIT05903.1	MC45_00690	MC45_05195	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aminoglycoside phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.474
AIT05191.1	AIT05905.1	MC45_00690	MC45_05205	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.858
AIT05191.1	AIT05923.1	MC45_00690	MC45_05310	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	isovaleryl-CoA dehydrogenase; Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.858
AIT05191.1	AIT05924.1	MC45_00690	MC45_05315	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.527
AIT05191.1	AIT05925.1	MC45_00690	MC45_05325	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.538
AIT05191.1	AIT06159.1	MC45_00690	MC45_06865	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nodulation protein NodN; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.538
AIT05191.1	AIT06160.1	MC45_00690	MC45_06870	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family.	0.999
AIT05191.1	AIT06178.1	MC45_00690	MC45_06975	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family.	0.999
AIT05191.1	AIT06610.1	MC45_00690	MC45_09770	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family.	0.920
AIT05191.1	AIT06611.1	MC45_00690	MC45_09775	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.920
AIT05191.1	AIT06703.1	MC45_00690	MC45_10320	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family.	0.999
AIT05191.1	AIT06748.1	MC45_00690	MC45_10630	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	succinyl-CoA:3-ketoacid-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.942
AIT05191.1	AIT06751.1	MC45_00690	MC45_10645	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	succinyl-CoA:3-ketoacid-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.937
AIT05191.1	AIT06790.1	MC45_00690	MC45_10875	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.883
AIT05191.1	AIT07221.1	MC45_00690	MC45_13550	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.767