STRINGSTRING
APC38617.1 APC38617.1 APC38618.1 APC38618.1 recF recF APC38620.1 APC38620.1 gyrB-2 gyrB-2 gyrA gyrA dnaX dnaX APC38676.1 APC38676.1 topB topB APC39436.1 APC39436.1 APC39485.1 APC39485.1 APC39982.1 APC39982.1 APC40516.1 APC40516.1 APC40840.1 APC40840.1 APC40897.1 APC40897.1 recA recA polC polC topA topA rnhB rnhB APC41080.1 APC41080.1 APC41203.1 APC41203.1 APC41204.1 APC41204.1 APC41205.1 APC41205.1 gyrB gyrB APC41207.1 APC41207.1 dnaG dnaG APC41316.1 APC41316.1 polA polA APC42730.1 APC42730.1 APC42732.1 APC42732.1 APC41445.1 APC41445.1 APC41446.1 APC41446.1 APC41462.1 APC41462.1 APC41713.1 APC41713.1 dinB-2 dinB-2 ligA ligA APC42077.1 APC42077.1 APC42785.1 APC42785.1 APC42159.1 APC42159.1 APC42191.1 APC42191.1 APC42237.1 APC42237.1 sbcD sbcD addA addA addB addB APC42488.1 APC42488.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APC38617.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (369 aa)
APC38618.1RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (68 aa)
recFDNA replication/repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (363 aa)
APC38620.1DUF370 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (87 aa)
gyrB-2DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (634 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (856 aa)
dnaXDNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (538 aa)
APC38676.1Hypothetical protein; Catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
topBDNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] (722 aa)
APC39436.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (741 aa)
APC39485.1DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
APC39982.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (460 aa)
APC40516.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S24 family. (499 aa)
APC40840.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (581 aa)
APC40897.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (109 aa)
recARecombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (351 aa)
polCPolC-type DNA polymerase III; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1445 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (701 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (272 aa)
APC41080.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
APC41203.1single-stranded-DNA-specific exonuclease RecJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (589 aa)
APC41204.1Peptidase M16; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase M16 family. (418 aa)
APC41205.1DNA topoisomerase IV; Decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; Derived by automated computational analysis using gene prediction method: Protein Homology. (968 aa)
gyrBNegatively supercoils closed circular double-stranded DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (653 aa)
APC41207.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (590 aa)
APC41316.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (871 aa)
APC42730.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (676 aa)
APC42732.1DNA topoisomerase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (657 aa)
APC41445.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (950 aa)
APC41446.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (447 aa)
APC41462.1Hypothetical protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (383 aa)
APC41713.1ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (722 aa)
dinB-2DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (401 aa)
ligADNA ligase (NAD(+)) LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (664 aa)
APC42077.1ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology. (759 aa)
APC42785.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (722 aa)
APC42159.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1193 aa)
APC42191.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DNA mismatch repair MutS family. (608 aa)
APC42237.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1199 aa)
sbcDExonuclease SbcCD subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (418 aa)
addAHelicase-exonuclease AddAB subunit AddA; ATP-dependent DNA helicase. (1348 aa)
addBHelicase-exonuclease AddAB subunit AddB; ATP-dependent DNA helicase; Belongs to the helicase family. AddB/RexB type 1 subfamily. (1202 aa)
APC42488.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (443 aa)
Your Current Organism:
Clostridium estertheticum
NCBI taxonomy Id: 1552
Other names: C. estertheticum subsp. estertheticum, Clostridium estertheticum subsp. estertheticum
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