STRINGSTRING
OJG68686.1 OJG68686.1 OJG68725.1 OJG68725.1 OJG68828.1 OJG68828.1 plsY plsY OJG69002.1 OJG69002.1 OJG69018.1 OJG69018.1 OJG69081.1 OJG69081.1 OJG69084.1 OJG69084.1 OJG69132.1 OJG69132.1 OJG69141.1 OJG69141.1 OJG69142.1 OJG69142.1 OJG69169.1 OJG69169.1 OJG69170.1 OJG69170.1 OJG69198.1 OJG69198.1 OJG69215.1 OJG69215.1 OJG69218.1 OJG69218.1 OJG69258.1 OJG69258.1 OJG69259.1 OJG69259.1 OJG69324.1 OJG69324.1 OJG69325.1 OJG69325.1 OJG69326.1 OJG69326.1 OJG66616.1 OJG66616.1 fabH fabH acpP acpP OJG66622.1 OJG66622.1 OJG66623.1 OJG66623.1 OJG66624.1 OJG66624.1 OJG66625.1 OJG66625.1 OJG66626.1 OJG66626.1 fabZ fabZ OJG66628.1 OJG66628.1 accD accD accA accA OJG66168.1 OJG66168.1 leuA leuA leuB leuB leuC leuC leuD leuD fumC fumC OJG65644.1 OJG65644.1 OJG65670.1 OJG65670.1 OJG65168.1 OJG65168.1 OJG64757.1 OJG64757.1 OJG64758.1 OJG64758.1 OJG64760.1 OJG64760.1 OJG68243.1 OJG68243.1 OJG68446.1 OJG68446.1 OJG64172.1 OJG64172.1 OJG64173.1 OJG64173.1 OJG67867.1 OJG67867.1 OJG67908.1 OJG67908.1 ilvD ilvD OJG67951.1 OJG67951.1 OJG67952.1 OJG67952.1 ilvC ilvC ilvA ilvA OJG68009.1 OJG68009.1 OJG68118.1 OJG68118.1 OJG68125.1 OJG68125.1 plsX plsX acpP-2 acpP-2 OJG67747.1 OJG67747.1 OJG67184.1 OJG67184.1 ackA ackA OJG67302.1 OJG67302.1 OJG67021.1 OJG67021.1 acpS acpS birA birA ldh ldh OJG66748.1 OJG66748.1 fabZ-2 fabZ-2 OJG66781.1 OJG66781.1 OJG66782.1 OJG66782.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OJG68686.1Pyruvate, phosphate dikinase. (869 aa)
OJG68725.1Hypothetical protein. (219 aa)
OJG68828.1Acetaldehyde dehydrogenase (acetylating). (441 aa)
plsYGlycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (206 aa)
OJG69002.1Hypothetical protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (331 aa)
OJG69018.1Acylphosphatase. (86 aa)
OJG69081.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1142 aa)
OJG69084.1Alcohol dehydrogenase. (339 aa)
OJG69132.1Acetaldehyde dehydrogenase (acetylating). (486 aa)
OJG69141.1Hypothetical protein. (83 aa)
OJG69142.1Propanol dehydrogenase PduQ. (280 aa)
OJG69169.1Alpha-acetolactate decarboxylase. (237 aa)
OJG69170.1Acetolactate synthase, catabolic; Belongs to the TPP enzyme family. (554 aa)
OJG69198.1Hypothetical protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (255 aa)
OJG69215.1Hypothetical protein. (548 aa)
OJG69218.1Pyruvate oxidase; Belongs to the TPP enzyme family. (574 aa)
OJG69258.1Hypothetical protein; Belongs to the BI1 family. (205 aa)
OJG69259.1MaoC family protein. (160 aa)
OJG69324.1Isocitrate dehydrogenase, NADP-dependent. (417 aa)
OJG69325.12-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family. (381 aa)
OJG69326.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
OJG66616.12-hydroxy-3-oxopropionate reductase. (296 aa)
fabH3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (319 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (74 aa)
OJG66622.1Enoyl-(acyl-carrier-protein) reductase II. (299 aa)
OJG66623.1Malonyl CoA-acyl carrier protein transacylase. (309 aa)
OJG66624.13-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa)
OJG66625.1Beta-ketoacyl-acyl-carrier-protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (411 aa)
OJG66626.1acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (166 aa)
fabZ(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase 2; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (139 aa)
OJG66628.1acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (456 aa)
accDAcetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (288 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (261 aa)
OJG66168.1Phosphopantetheine-protein transferase domain; Belongs to the P-Pant transferase superfamily. (185 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (507 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (348 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (458 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (195 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (445 aa)
OJG65644.1Hypothetical protein. (397 aa)
OJG65670.1Phosphate acetyltransferase. (326 aa)
OJG65168.13-ketoacyl-(acyl-carrier-protein) reductase. (262 aa)
OJG64757.1Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family. (4626 aa)
OJG64758.1Amino acid adenylation domain-containing protein. (2996 aa)
OJG64760.1Hypothetical protein. (226 aa)
OJG68243.1NADH-dependent butanol dehydrogenase A. (403 aa)
OJG68446.1Hypothetical protein. (295 aa)
OJG64172.1Hypothetical protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)
OJG64173.1Hypothetical protein. (334 aa)
OJG67867.1Hypothetical protein. (257 aa)
OJG67908.1Hypothetical protein. (348 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (563 aa)
OJG67951.1Acetolactate synthase, large subunit, biosynthetic type. (564 aa)
OJG67952.1Acetolactate synthase, small subunit. (160 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (417 aa)
OJG68009.1Hypothetical protein. (329 aa)
OJG68118.1Pyruvate:ferredoxin (flavodoxin) oxidoreductase. (1182 aa)
OJG68125.1Flavocytochrome c; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (517 aa)
plsXPhosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (332 aa)
acpP-2Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa)
OJG67747.1Short chain dehydrogenase. (264 aa)
OJG67184.1Pyruvate:ferredoxin (flavodoxin) oxidoreductase. (1225 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa)
OJG67302.1Hypothetical protein; Belongs to the aldehyde dehydrogenase family. (461 aa)
OJG67021.1Bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (865 aa)
acpSHolo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (117 aa)
birAbiotin-[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (317 aa)
ldhL-lactate dehydrogenase 1; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (326 aa)
OJG66748.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (498 aa)
fabZ-2(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase 1; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (140 aa)
OJG66781.1Beta-ketoacyl-acyl-carrier-protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (412 aa)
OJG66782.1Enoyl-(acyl carrier protein) reductase. (250 aa)
Your Current Organism:
Enterococcus moraviensis
NCBI taxonomy Id: 155617
Other names: ATCC BAA-383, CCM 4856, CCUG 45913, CIP 107130, E. moraviensis, Enterococcus moraviensis Svec et al. 2001, LMG 19486, LMG:19486, NBRC 100710, strain 330
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