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hpt hpt pyrH pyrH gpt gpt yaiE yaiE apt apt gsk gsk ushA ushA tmk tmk tdk tdk add add amn amn udk udk cdd cdd yeiK yeiK yfbR yfbR upp upp ygdH ygdH yrfG yrfG yicP yicP udp udp cpdB cpdB yjjG yjjG deoC deoC deoA deoA deoB deoB deoD deoD
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Your Input:
hptHypoxanthine phosphoribosyltransferase; Residues 1 to 182 of 182 are 100.00 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 Strain MG1655: B0125; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (182 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
gptGuanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa)
yaiEOrf, hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (94 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa)
gskInosine-guanosine kinase; Residues 1 to 434 of 434 are 100.00 pct identical to residues 1 to 434 of 434 from Escherichia coli K-12 Strain MG1655: B0477; Belongs to the carbohydrate kinase PfkB family. (434 aa)
ushAUDP-sugar hydrolase (5'-nucleotidase); Residues 1 to 550 of 550 are 99.27 pct identical to residues 1 to 550 of 550 from Escherichia coli K-12 Strain MG1655: B0480; Belongs to the 5'-nucleotidase family. (550 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa)
tdkThymidine kinase; Phosphorylates both thymidine and deoxyuridine. (205 aa)
addAdenosine deaminase; Residues 1 to 333 of 333 are 99.39 pct identical to residues 1 to 333 of 333 from Escherichia coli K-12 Strain MG1655: B1623; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (333 aa)
amnAMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (484 aa)
udkUridine/cytidine kinase; Residues 1 to 231 of 231 are 100.00 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 Strain MG1655: B2066; Belongs to the uridine kinase family. (231 aa)
cddCytidine/deoxycytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (294 aa)
yeiKOrf, hypothetical protein; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides; Belongs to the IUNH family. RihB subfamily. (313 aa)
yfbRPutative alpha helix protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (199 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (217 aa)
ygdHOrf, hypothetical protein; Catalyzes the hydrolysis of the N-glycosidic bond of diverse pyrimidine and purine nucleotide 5'-monophosphates, to form ribose 5- phosphate and the corresponding free base. Can use AMP, GMP, IMP, CMP, dTMP and UMP as substrates. Cannot catalyze the reverse reactions. May contribute to nucleoside pool homeostasis by degrading excess nucleotides and feeding back the ribose moiety to catabolism. Belongs to the LOG family. (454 aa)
yrfGPutative phosphatase; Residues 1 to 237 of 237 are 99.57 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 Strain MG1655: B3399. (237 aa)
yicPProbable adenine deaminase (synthesis xanthine); Residues 1 to 588 of 588 are 98.97 pct identical to residues 1 to 588 of 588 from Escherichia coli K-12 Strain MG1655: B3665. (588 aa)
udpUridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (253 aa)
cpdB2':3'-cyclic-nucleotide 2'-phosphodiesterase; Residues 1 to 647 of 647 are 99.38 pct identical to residues 1 to 647 of 647 from Escherichia coli K-12 Strain MG1655: B4213; Belongs to the 5'-nucleotidase family. (647 aa)
yjjGPutative phosphatase; Nucleotidase that shows high phosphatase activity toward non- canonical pyrimidine nucleotides and three canonical nucleoside 5'- monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6-phosphogluconate. Appears to function as a house-cleaning nucleotidase in vivo, since the general nucleotidase activity of YjjG allows it to protect cells against non- canonical pyrimidine derivatives such as 5-fluoro-2'-deoxyuridine, 5- fluorouridine, 5-fluoroorotate, 5-fluorouracil, and 5-aza-2'- deoxycytidine, and prevents t [...] (225 aa)
deoC2-deoxyribose-5-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (259 aa)
deoAThymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (440 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa)
deoDPurine-nucleoside phosphorylase; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules; Belongs to the PNP/UDP phosphorylase family. (239 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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