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seqA seqA fadR fadR yejK yejK yejL yejL yejM yejM yfbV yfbV syd syd argR argR yheV yheV yihI yihI yijC yijC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
seqANegative modulator of initiation of replication; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. (181 aa)
fadRNegative regulator for fad regulon, and positive activator of fabA; Multifunctional regulator of fatty acid metabolism. (239 aa)
yejKOrf, hypothetical protein; Residues 1 to 335 of 335 are 99.70 pct identical to residues 1 to 335 of 335 from Escherichia coli K-12 Strain MG1655: B2186. (335 aa)
yejLOrf, hypothetical protein; Residues 1 to 75 of 75 are 100.00 pct identical to residues 1 to 75 of 75 from Escherichia coli K-12 Strain MG1655: B2187; Belongs to the UPF0352 family. (75 aa)
yejMPutative sulfatase; Residues 1 to 586 of 586 are 100.00 pct identical to residues 1 to 586 of 586 from Escherichia coli K-12 Strain MG1655: B2188. (586 aa)
yfbVOrf, hypothetical protein; Residues 1 to 151 of 151 are 100.00 pct identical to residues 1 to 151 of 151 from Escherichia coli K-12 Strain MG1655: B2295. (151 aa)
sydInteracts with secY; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family. (181 aa)
argRRepressor of arg regulon; Regulates arginine biosynthesis genes; Belongs to the ArgR family. (156 aa)
yheVHypothetical protein; No significant matches. (66 aa)
yihIOrf, hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. (168 aa)
yijCOrf, hypothetical protein; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. (234 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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