STRINGSTRING
yabF yabF kefC kefC yadQ yadQ aefA aefA ybaL ybaL ybdG ybdG kdpE kdpE kdpD kdpD kdpC kdpC kdpB kdpB kdpA kdpA ybiO ybiO nhaP2 nhaP2 kch kch ynaI ynaI yggB yggB yrdB yrdB yrdD yrdD smg smg fmt fmt sun sun trkA trkA mscL mscL kefB kefB yheR yheR kup kup trkH trkH yjbA yjbA dinF dinF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yabFPutative NAD(P)H oxidoreductase; Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC; Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily. (176 aa)
kefCK+ efflux antiporter, glutathione-regulated; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (620 aa)
yadQPutative channel transporter; Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response. (473 aa)
aefAHypothetical protein; Residues 1 to 1120 of 1120 are 99.73 pct identical to residues 1 to 1120 of 1120 from Escherichia coli K-12 Strain MG1655: B0465. (1120 aa)
ybaLPutative transport protein; Residues 1 to 558 of 558 are 99.82 pct identical to residues 1 to 558 of 558 from Escherichia coli K-12 Strain MG1655: B0478; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (558 aa)
ybdGPutative transport; Residues 1 to 415 of 415 are 99.75 pct identical to residues 1 to 415 of 415 from Escherichia coli K-12 Strain MG1655: B0577. (415 aa)
kdpERegulator of kdp operon (transcriptional effector); Residues 1 to 225 of 225 are 98.66 pct identical to residues 1 to 225 of 225 from Escherichia coli K-12 Strain MG1655: B0694. (225 aa)
kdpDSensor for high-affinity potassium transport system; Residues 1 to 894 of 894 are 99.55 pct identical to residues 1 to 894 of 894 from Escherichia coli K-12 Strain MG1655: B0695. (894 aa)
kdpCHigh-affinity potassium transport system; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (190 aa)
kdpBATPase of high-affinity potassium transport system, B chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (682 aa)
kdpAATPase of high-affinity potassium transport system, A chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (557 aa)
ybiOPutative transport protein; Residues 1 to 741 of 741 are 99.59 pct identical to residues 46 to 786 of 786 from Escherichia coli K-12 Strain MG1655: B0808. (741 aa)
nhaP2Orf, hypothetical protein; K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily. (536 aa)
kchPutative potassium channel protein; Residues 1 to 417 of 417 are 99.52 pct identical to residues 1 to 417 of 417 from Escherichia coli K-12 Strain MG1655: B1250. (417 aa)
ynaIOrf, hypothetical protein; Residues 1 to 343 of 343 are 100.00 pct identical to residues 1 to 343 of 343 from Escherichia coli K-12 Strain MG1655: B1330; Belongs to the MscS (TC 1.A.23) family. (343 aa)
yggBPutative transport protein; Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage; as the membrane is depolarized, less tension is required to open the channel and vice versa. The channel is characterized by short bursts of activity that last for a few s [...] (286 aa)
yrdBOrf, hypothetical protein; Residues 1 to 85 of 85 are 97.64 pct identical to residues 1 to 85 of 85 from Escherichia coli K-12 Strain MG1655: B3280. (85 aa)
yrdDPutative DNA topoisomerase; Residues 11 to 172 of 172 are 96.29 pct identical to residues 8 to 169 of 169 from Escherichia coli K-12 Strain MG1655: B3283. (172 aa)
smgOrf, hypothetical protein; Residues 1 to 157 of 157 are 97.45 pct identical to residues 1 to 157 of 157 from Escherichia coli K-12 Strain MG1655: B3284; Belongs to the Smg family. (157 aa)
fmt10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus. (315 aa)
sunOrf, hypothetical protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (429 aa)
trkATransport of potassium; Part of the constitutive potassium transport systems TrkG and TrkH. May regulate the transport activity of TrkG and TrkH systems. Binds to NAD(+) and NADH (By similarity). (458 aa)
mscLMechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. (136 aa)
kefBK+ efflux; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (592 aa)
yheRPutative NAD(P)H oxidoreductase; Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB. (184 aa)
kupLow affinity potassium transport system protein; Responsible for the low-affinity transport of potassium into the cell, with the probable concomitant uptake of protons (symport system); Belongs to the HAK/KUP transporter (TC 2.A.72) family. (622 aa)
trkHPotassium uptake protein, requires TrkE; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA and requires TrkE for transport activity (By similarity); Belongs to the TrkH potassium transport family. (483 aa)
yjbAOrf, hypothetical protein; Residues 1 to 136 of 136 are 98.52 pct identical to residues 1 to 136 of 136 from Escherichia coli K-12 Strain MG1655: B4030. (136 aa)
dinFDNA-damage-inducible protein F; Residues 1 to 459 of 459 are 98.25 pct identical to residues 1 to 459 of 459 from Escherichia coli K-12 Strain MG1655: B4044. (459 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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