STRINGSTRING
ybbB ybbB dmsA dmsA dmsB dmsB dmsC dmsC torS torS torT torT torR torR torC torC torA torA torD torD fdnI fdnI fdnH fdnH fdnG fdnG ynfF_2 ynfF_2 ynfF_3 ynfF_3 ynfG_2 ynfG_2 ynfH_1 ynfH_1 dmsD dmsD selD selD bisZ bisZ yecK yecK ccmH ccmH dsbE dsbE ccmF ccmF ccmE ccmE ccmD ccmD ccmC ccmC ccmB ccmB ccmA ccmA napC napC napB napB napH napH napG napG napA napA napD napD napF napF ynfH_2 ynfH_2 dmsB-2 dmsB-2 ynfF_4 ynfF_4 bisC bisC yiaD yiaD yiaI yiaI selB selB selA selA fdhE fdhE fdoI fdoI fdoH fdoH fdoG fdoG fdhD fdhD nrfA nrfA nrfB nrfB nrfC nrfC nrfD nrfD nrfE nrfE nrfF nrfF nrfG nrfG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ybbBPutative capsule anchoring protein; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. (364 aa)
dmsAAnaerobic dimethyl sulfoxide reductase subunit A; Residues 1 to 785 of 785 are 99.74 pct identical to residues 1 to 785 of 785 from Escherichia coli K-12 Strain MG1655: B0894; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (785 aa)
dmsBAnaerobic dimethyl sulfoxide reductase subunit B; Residues 1 to 205 of 205 are 99.51 pct identical to residues 1 to 205 of 205 from Escherichia coli K-12 Strain MG1655: B0895. (205 aa)
dmsCAnaerobic dimethyl sulfoxide reductase subunit C; Residues 1 to 287 of 287 are 98.60 pct identical to residues 1 to 287 of 287 from Escherichia coli K-12 Strain MG1655: B0896. (287 aa)
torSSensor protein torS (regulator TorR); Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Detects the presence of TMAO in the medium and, in response, activates TorR via a four-step phosphorelay. When TMAO is removed, TorS can dephosphorylate TorR, probably by a reverse phosphorelay involving His- 860 and Asp-733 (By similarity). (904 aa)
torTPart of regulation of tor operon, periplasmic; Upon binding a putative inducer it probably interacts with TorS and allows it to play a role in the induction of the torCAD operon for trimethylamine N-oxide reductase; Belongs to the bacterial solute-binding protein 2 family. (342 aa)
torRResponse transcriptional regulator for torA (sensor TorS); Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Phosphorylated TorR activates the transcription of the torCAD operon by binding to four decameric boxes located in the torCAD promoter. Box1, 2 and 4 contain the DNA sequence 5'-CTGTTCATAT-3' and box3 contains the DNA sequence 5'-CCGTTCATCC-3'. Phosphorylated as well as unphosphorylated TorR negatively regulates its own expression by binding to box1 and 2 (By similarity). (230 aa)
torCTrimethylamine N-oxide reductase, cytochrome c-type subunit; Part of the anaerobic respiratory chain of trimethylamine-N- oxide reductase TorA. Acts by transferring electrons from the membranous menaquinones to TorA. This transfer probably involves an electron transfer pathway from menaquinones to the N-terminal domain of TorC, then from the N-terminus to the C-terminus, and finally to TorA. TorC apocytochrome negatively autoregulates the torCAD operon probably by inhibiting the TorS kinase activity (By similarity); Belongs to the TorC/TorY family. (390 aa)
torATrimethylamine N-oxide reductase subunit; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (848 aa)
torDPart of trimethylamine-N-oxide oxidoreductase; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity); Belongs to the TorD/DmsD family. TorD subfamily. (199 aa)
fdnIFormate dehydrogenase-N, nitrate-inducible, cytochrome B556(Fdn) gamma subunit; Formate dehydrogenase allows the bacterium to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. Subunit gamma is the cytochrome b556 component of the formate dehydrogenase-N, and also contains a menaquinone reduction site that receives electrons from the beta subunit (FdnH), through its hemes. Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar) (By similarity). (217 aa)
fdnHFormate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (294 aa)
fdnGFormate dehydrogenase-N, nitrate-inducible, alpha subunit; Residues 1 to 1015 of 1015 are 99.70 pct identical to residues 1 to 1015 of 1015 from Escherichia coli K-12 Strain MG1655: B1474. (1015 aa)
ynfF_2Putative oxidoreductase, major subunit; Residues 1 to 808 of 808 are 98.51 pct identical to residues 1 to 808 of 808 from Escherichia coli K-12 Strain MG1655: B1587; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (808 aa)
ynfF_3Putative oxidoreductase, major subunit; Residues 1 to 808 of 808 are 99.50 pct identical to residues 1 to 808 of 808 from Escherichia coli K-12 Strain MG1655: B1588; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (808 aa)
ynfG_2Putative oxidoreductase, Fe-S subunit; Residues 1 to 205 of 205 are 100.00 pct identical to residues 1 to 205 of 205 from Escherichia coli K-12 Strain MG1655: B1589. (205 aa)
ynfH_1Putative DMSO reductase anchor subunit; Residues 1 to 284 of 284 are 97.88 pct identical to residues 1 to 284 of 284 from Escherichia coli K-12 Strain MG1655: B1590. (284 aa)
dmsDPutative oxidoreductase component; Required for biogenesis/assembly of DMSO reductase, but not for the interaction of the DmsA signal peptide with the Tat system. May be part of a chaperone cascade complex that facilitates a folding- maturation pathway for the substrate protein. (207 aa)
selDSelenophosphate synthase, H(2)Se added to acrylyl-tRNA; Synthesizes selenophosphate from selenide and ATP. (347 aa)
bisZBiotin sulfoxide reductase 2; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N- oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency (By similarity); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (815 aa)
yecKPutative cytochrome C-type protein; Part of the anaerobic respiratory chain of trimethylamine-N- oxide reductase TorZ. Required for electron transfer to the TorZ terminal enzyme (By similarity). (366 aa)
ccmHPossible subunit of heme lyase; Possible subunit of a heme lyase. (350 aa)
dsbEDisulfide oxidoreductase (in biogenesis of cytochrome c; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity); Belongs to the thioredoxin family. DsbE subfamily. (185 aa)
ccmFCytochrome c-type biogenesis protein; Residues 1 to 647 of 647 are 99.69 pct identical to residues 1 to 647 of 647 from Escherichia coli K-12 Strain MG1655: B2196. (647 aa)
ccmECytochrome c biogenesis, possible subunit of a heme lyase; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (159 aa)
ccmDHeme exporter protein C; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family. (69 aa)
ccmCHeme exporter protein C; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (245 aa)
ccmBHeme exporter protein B, cytochrome c-type biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. (220 aa)
ccmAATP binding protein of heme exporter A; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (205 aa)
napCCytochrome c-type protein; Mediates electron flow from quinones to the NapAB complex. (200 aa)
napBCytochrome c-type protein; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (156 aa)
napHFerredoxin-type protein: electron transfer; Residues 1 to 287 of 287 are 99.65 pct identical to residues 1 to 287 of 287 from Escherichia coli K-12 Strain MG1655: B2204. (287 aa)
napGFerredoxin-type protein: electron transfer; Residues 1 to 231 of 231 are 99.56 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 Strain MG1655: B2205. (231 aa)
napAProbable nitrate reductase 3; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (828 aa)
napDOrf, hypothetical protein; Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin- arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export. (87 aa)
napFFerredoxin-type protein: electron transfer; Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm; Belongs to the NapF family. (164 aa)
ynfH_2Putative dimethyl sulfoxide reductase subunit C; Residues 2 to 272 of 273 are 25.26 pct identical to residues 6 to 276 of 286 from GenPept 118 : gi|5002126|gb|AAD37317.1|AF135170_8 (AF135170) dimethyl sulfoxide reductase subunit C [Yersinia pestis]. (273 aa)
dmsB-2Putative dimethyl sulfoxide reductase subunit B; Residues 4 to 134 of 145 are 61.83 pct identical to residues 57 to 186 of 205 from GenPept 118 : gi|1787122|gb|AAC73981.1| (AE000191) anaerobic dimethyl sulfoxide reductase subunit B [Escherichia coli]. (145 aa)
ynfF_4Putative dimethyl sulfoxide reductase subunit A; Residues 25 to 792 of 793 are 43.59 pct identical to residues 3 to 784 of 785 from GenPept 118 : gi|1787121|gb|AAC73980.1| (AE000191) anaerobic dimethyl sulfoxide reductase subunit A [Escherichia coli]; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (793 aa)
bisCBiotin sulfoxide reductase; Residues 1 to 739 of 739 are 98.78 pct identical to residues 1 to 739 of 739 from Escherichia coli K-12 Strain MG1655: B3551; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (739 aa)
yiaDPutative outer membrane protein; Residues 1 to 219 of 219 are 99.08 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 Strain MG1655: B3552. (219 aa)
yiaIOrf, hypothetical protein; Residues 1 to 157 of 157 are 98.72 pct identical to residues 1 to 157 of 157 from Escherichia coli K-12 Strain MG1655: B3573. (157 aa)
selBselenocysteinyl-tRNA-specific translation factor; Residues 1 to 614 of 614 are 98.37 pct identical to residues 1 to 614 of 614 from Escherichia coli K-12 Strain MG1655: B3590. (614 aa)
selASelenocysteine synthase: L-seryl-tRNA (Ser) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. (463 aa)
fdhEAffects formate dehydrogenase-N; Residues 1 to 309 of 309 are 99.02 pct identical to residues 1 to 309 of 309 from Escherichia coli K-12 Strain MG1655: B3891. (309 aa)
fdoIFormate dehydrogenase, cytochrome B556 (FDO) subunit; Allows to use formate as major electron donor during aerobic respiration. Subunit gamma is probably the cytochrome b556(FDO) component of the formate dehydrogenase (By similarity). (211 aa)
fdoHFormate dehydrogenase-O, iron-sulfur subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (300 aa)
fdoGFormate dehydrogenase-O, major subunit; Residues 1 to 1016 of 1016 are 99.51 pct identical to residues 1 to 1016 of 1016 from Escherichia coli K-12 Strain MG1655: B3894. (1016 aa)
fdhDAffects formate dehydrogenase-N; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (277 aa)
nrfAPeriplasmic cytochrome c(552): plays a role in nitrite reduction; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (478 aa)
nrfBFormate-dependent nitrite reductase; Residues 1 to 190 of 190 are 100.00 pct identical to residues 1 to 190 of 190 from Escherichia coli K-12 Strain MG1655: B4071. (190 aa)
nrfCFormate-dependent nitrite reductase; Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes. (223 aa)
nrfDFormate-dependent nitrate reductase complex; Residues 1 to 318 of 318 are 99.05 pct identical to residues 1 to 318 of 318 from Escherichia coli K-12 Strain MG1655: B4073. (318 aa)
nrfEFormate-dependent nitrite reductase; Residues 1 to 551 of 552 are 98.18 pct identical to residues 1 to 551 of 552 from Escherichia coli K-12 Strain MG1655: B4074. (552 aa)
nrfFPart of formate-dependent nitrite reductase complex; Not required for the biosynthesis of any of the c-type cytochromes. Possible subunit of a heme lyase; Belongs to the CcmH/CycL/Ccl2/NrfF family. (127 aa)
nrfGPart of formate-dependent nitrite reductase complex; Required for formate-dependent nitrite reduction. Not required for the biosynthesis of any of the c-type cytochromes nor for the secretion of the periplasmic cytochromes. (198 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.