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fhiA fhiA mbhA mbhA yahA yahA yaiC yaiC ylaB ylaB yliE yliE dgcI dgcI ycdT ycdT Z1528 Z1528 flgN flgN flgM flgM flgA flgA flgB flgB flgC flgC flgD flgD flgE flgE flgF flgF flgG flgG flgH flgH flgI flgI flgJ flgJ flgK flgK flgL flgL ycgR ycgR ydeH ydeH dgcF dgcF dosC dosC Z2220 Z2220 Z2221 Z2221 trg trg dgcM dgcM yciR yciR yeaI yeaI yeaJ yeaJ Z2836 Z2836 yoaD yoaD flhA flhA flhB flhB cheZ cheZ cheY cheY cheB cheB cheR cheR tap tap tar tar cheW cheW cheA cheA motB motB motA motA flhC flhC flhD flhD fliZ fliZ fliA fliA fliC fliC fliD fliD fliS fliS fliE fliE fliF fliF fliG fliG fliH fliH fliI fliI fliJ fliJ fliK fliK fliL fliL fliM fliM fliN fliN fliO fliO fliP fliP fliQ fliQ fliR fliR dgcQ dgcQ Z3235 Z3235 Z3236 Z3236 yehV yehV rtn rtn yfeA yfeA yfgF yfgF aer aer yhdA yhdA yhjH yhjH yhjK yhjK yjcC yjcC Z5692 Z5692 Z5693 Z5693 tsr tsr
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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fhiAFlagellar biosynthesis; Residues 1 to 578 of 579 are 98.96 pct identical to residues 1 to 578 of 579 from Escherichia coli K-12 Strain MG1655: B0229. (579 aa)
mbhAPutative motility protein; Residues 1 to 261 of 261 are 99.23 pct identical to residues 1 to 261 of 261 from Escherichia coli K-12 Strain MG1655: B0230. (261 aa)
yahAOrf, hypothetical protein; Residues 4 to 365 of 365 are 93.09 pct identical to residues 1 to 362 of 362 from Escherichia coli K-12 Strain MG1655: B0315. (365 aa)
yaiCOrf, hypothetical protein; Residues 1 to 371 of 371 are 99.73 pct identical to residues 1 to 371 of 371 from Escherichia coli K-12 Strain MG1655: B0385. (371 aa)
ylaBOrf, hypothetical protein; Residues 1 to 518 of 518 are 98.84 pct identical to residues 1 to 518 of 518 from Escherichia coli K-12 Strain MG1655: B0457. (518 aa)
yliEOrf, hypothetical protein; Residues 1 to 782 of 782 are 99.36 pct identical to residues 1 to 782 of 782 from Escherichia coli K-12 Strain MG1655: B0833. (782 aa)
dgcIOrf, hypothetical protein; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules. (442 aa)
ycdTOrf, hypothetical protein; Residues 1 to 452 of 452 are 98.67 pct identical to residues 1 to 452 of 452 from Escherichia coli K-12 Strain MG1655: B1025. (452 aa)
Z1528Hypothetical protein; Residues 35 to 532 of 536 are 31.11 pct identical to residues 8 to 509 of 518 from GenPept 118 : gi|1788502|gb|AAC75237.1| (AE000307) orf, hypothetical protein [Escherichia coli]. (536 aa)
flgNProtein of flagellar biosynthesis; Residues 1 to 138 of 138 are 98.55 pct identical to residues 1 to 138 of 138 from Escherichia coli K-12 Strain MG1655: B1070. (138 aa)
flgManti-FliA (anti-sigma) factor; Residues 1 to 97 of 97 are 98.96 pct identical to residues 1 to 97 of 97 from Escherichia coli K-12 Strain MG1655: B1071. (97 aa)
flgAFlagellar biosynthesis; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P- ring assembly; Belongs to the FlgA family. (219 aa)
flgBFlagellar biosynthesis, cell-proximal portion of basal-body rod; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body. (138 aa)
flgCFlagellar biosynthesis, cell-proximal portion of basal-body rod; Residues 1 to 134 of 134 are 100.00 pct identical to residues 1 to 134 of 134 from Escherichia coli K-12 Strain MG1655: B1074; Belongs to the flagella basal body rod proteins family. (134 aa)
flgDFlagellar biosynthesis, initiation of hook assembly; Required for flagellar hook formation. May act as a scaffolding protein. (231 aa)
flgEFlagellar biosynthesis, hook protein; Residues 1 to 401 of 401 are 94.77 pct identical to residues 1 to 402 of 402 from Escherichia coli K-12 Strain MG1655: B1076. (401 aa)
flgFFlagellar biosynthesis, cell-proximal portion of basal-body rod; Residues 1 to 251 of 251 are 99.60 pct identical to residues 1 to 251 of 251 from Escherichia coli K-12 Strain MG1655: B1077. (251 aa)
flgGFlagellar biosynthesis, cell-distal portion of basal-body rod; Residues 1 to 260 of 260 are 100.00 pct identical to residues 1 to 260 of 260 from Escherichia coli K-12 Strain MG1655: B1078; Belongs to the flagella basal body rod proteins family. (260 aa)
flgHFlagellar biosynthesis, basal-body outer-membrane L (lipopolysaccharide layer) ring protein; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (232 aa)
flgIHomolog of Salmonella P-ring of flagella basal body; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (365 aa)
flgJFlagellar biosynthesis; Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; In the C-terminal section; belongs to the glycosyl hydrolase 73 family. (313 aa)
flgKFlagellar biosynthesis, hook-filament junction protein 1; Residues 1 to 547 of 547 are 99.08 pct identical to residues 1 to 547 of 547 from Escherichia coli K-12 Strain MG1655: B1082. (547 aa)
flgLFlagellar biosynthesis; Residues 1 to 317 of 317 are 98.10 pct identical to residues 1 to 317 of 317 from Escherichia coli K-12 Strain MG1655: B1083. (317 aa)
ycgRHypothetical protein; Residues 1 to 198 of 198 are 97.47 pct identical to residues 1 to 198 of 244 from Escherichia coli K-12 Strain MG1655: B1194. (198 aa)
ydeHOrf, hypothetical protein; Residues 1 to 296 of 296 are 98.64 pct identical to residues 1 to 296 of 296 from Escherichia coli K-12 Strain MG1655: B1535. (296 aa)
dgcFOrf, hypothetical protein; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules. (315 aa)
dosCOrf, hypothetical protein; Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus, catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria (By similarity). (460 aa)
Z2220Putative sensor kinase; Residues 1 to 416 of 421 are 99.03 pct identical to residues 1 to 416 of 807 from Escherichia coli K-12 Strain MG1655: B1489. (421 aa)
Z2221Hypothetical protein; Residues 1 to 367 of 367 are 98.63 pct identical to residues 441 to 807 of 807 from Escherichia coli K-12 Strain MG1655: B1489. (367 aa)
trgMethyl-accepting chemotaxis protein III, ribose sensor receptor; Residues 1 to 546 of 546 are 98.71 pct identical to residues 1 to 546 of 546 from Escherichia coli K-12 Strain MG1655: B1421. (546 aa)
dgcMOrf, hypothetical protein; Part of a signaling cascade that regulates curli biosynthesis. The cascade is composed of two cyclic-di-GMP (c-di-GMP) control modules, in which c-di-GMP controlled by the DgcE/PdeH pair (module I) regulates the activity of the DgcM/PdeR pair (module II), which in turn regulates activity of the transcription factor MlrA and expression of the master biofilm regulator csgD. (430 aa)
yciROrf, hypothetical protein; Residues 1 to 661 of 661 are 98.94 pct identical to residues 1 to 661 of 661 from Escherichia coli K-12 Strain MG1655: B1285. (661 aa)
yeaIOrf, hypothetical protein; Residues 1 to 444 of 444 are 100.00 pct identical to residues 48 to 491 of 491 from Escherichia coli K-12 Strain MG1655: B1785. (444 aa)
yeaJHypothetical protein; Residues 1 to 496 of 496 are 99.59 pct identical to residues 61 to 556 of 556 from Escherichia coli K-12 Strain MG1655: B1786. (496 aa)
Z2836Hypothetical protein; Residues 1 to 282 of 282 are 98.58 pct identical to residues 44 to 325 of 384 from Escherichia coli K-12 Strain MG1655: B1794. (282 aa)
yoaDOrf, hypothetical protein; Residues 1 to 542 of 542 are 99.07 pct identical to residues 1 to 542 of 542 from Escherichia coli K-12 Strain MG1655: B1815. (542 aa)
flhAFlagellar biosynthesis; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (692 aa)
flhBPutative part of export apparatus for flagellar proteins; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (382 aa)
cheZChemotactic response; Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P). (214 aa)
cheYChemotaxis regulator transmits chemoreceptor signals to flagelllar motor components; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation (By similarity). (129 aa)
cheBResponse regulator for chemotaxis (cheA sensor); Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (349 aa)
cheRResponse regulator for chemotaxis; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (286 aa)
tapMethyl-accepting chemotaxis protein IV, peptide sensor receptor; Residues 1 to 533 of 533 are 98.87 pct identical to residues 1 to 533 of 533 from Escherichia coli K-12 Strain MG1655: B1885. (533 aa)
tarMethyl-accepting chemotaxis protein II, aspartate sensor receptor; Residues 1 to 553 of 553 are 99.63 pct identical to residues 1 to 553 of 553 from Escherichia coli K-12 Strain MG1655: B1886. (553 aa)
cheWPositive regulator of CheA protein activity; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. It physically bridges CheA to the MCPs (methyl-accepting chemotaxis proteins) to allow regulated phosphotransfer to CheY and CheB (By similarity). (167 aa)
cheASensory transducer kinase between chemo- signal receptors and CheB and CheY; Residues 1 to 654 of 654 are 99.38 pct identical to residues 1 to 654 of 654 from Escherichia coli K-12 Strain MG1655: B1888. (654 aa)
motBEnables flagellar motor rotation, linking torque machinery to cell wall; MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity). (308 aa)
motAProton conductor component of motor; Residues 1 to 295 of 295 are 99.32 pct identical to residues 1 to 295 of 295 from Escherichia coli K-12 Strain MG1655: B1890. (295 aa)
flhCRegulator of flagellar biosynthesis acting on class 2 operons; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. (192 aa)
flhDRegulator of flagellar biosynthesis, acting on class 2 operons; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (119 aa)
fliZOrf, hypothetical protein; Residues 1 to 195 of 195 are 98.97 pct identical to residues 1 to 195 of 195 from Escherichia coli K-12 Strain MG1655: B1921. (195 aa)
fliAFlagellar biosynthesis; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (239 aa)
fliCFlagellar biosynthesis; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (585 aa)
fliDFlagellar biosynthesis; Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity). (465 aa)
fliSFlagellar biosynthesis; Residues 1 to 136 of 136 are 97.79 pct identical to residues 1 to 136 of 136 from Escherichia coli K-12 Strain MG1655: B1925. (136 aa)
fliEFlagellar biosynthesis; Residues 1 to 104 of 104 are 100.00 pct identical to residues 1 to 104 of 104 from Escherichia coli K-12 Strain MG1655: B1937. (104 aa)
fliFFlagellar biosynthesis; The M ring may be actively involved in energy transduction. Belongs to the FliF family. (552 aa)
fliGFlagellar motor switch protein FliG; FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity). (331 aa)
fliHFlagellar biosynthesis; Residues 1 to 235 of 235 are 99.14 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 Strain MG1655: B1940. (235 aa)
fliIFlagellum-specific ATP synthase; Residues 40 to 496 of 496 are 100.00 pct identical to residues 1 to 457 of 457 from Escherichia coli K-12 Strain MG1655: B1941. (496 aa)
fliJFlagellar fliJ protein; Flagellar protein that affects chemotactic events. Belongs to the FliJ family. (147 aa)
fliKFlagellar hook-length control protein; Residues 1 to 375 of 375 are 98.40 pct identical to residues 1 to 375 of 375 from Escherichia coli K-12 Strain MG1655: B1943. (375 aa)
fliLFlagellar biosynthesis; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family. (154 aa)
fliMFlagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. (334 aa)
fliNFlagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family. (137 aa)
fliOFlagelar biosynthesis; Residues 1 to 101 of 101 are 100.00 pct identical to residues 1 to 101 of 101 from Escherichia coli K-12 Strain MG1655: B1947. (101 aa)
fliPFlagellar biosynthesis; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (245 aa)
fliQFlagellar biosynthesis; Required for the assembly of the rivet at the earliest stage of flagellar biosynthesis; Belongs to the FliQ/MopD/SpaQ family. (89 aa)
fliRFlagellar biosynthesis; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (261 aa)
dgcQOrf, hypothetical protein; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Involved in the regulation of cellulose production (By similarity). (564 aa)
Z3235Partial putative sensor kinase; Residues 1 to 152 of 177 are 99.34 pct identical to residues 1 to 152 of 1105 from Escherichia coli K-12 Strain MG1655: B2067. (177 aa)
Z3236Partial putative sensor kinase; Residues 1 to 935 of 935 are 98.93 pct identical to residues 171 to 1105 of 1105 from Escherichia coli K-12 Strain MG1655: B2067. (935 aa)
yehVPutative transcriptional regulator; Residues 1 to 215 of 215 are 99.06 pct identical to residues 29 to 243 of 243 from Escherichia coli K-12 Strain MG1655: B2127. (215 aa)
rtnOrf, hypothetical protein; Residues 1 to 518 of 518 are 99.42 pct identical to residues 1 to 518 of 518 from Escherichia coli K-12 Strain MG1655: B2176. (518 aa)
yfeAOrf, hypothetical protein; Residues 1 to 742 of 742 are 99.59 pct identical to residues 27 to 768 of 768 from Escherichia coli K-12 Strain MG1655: B2395. (742 aa)
yfgFPutative cytochrome C-type biogenesis protein; Residues 1 to 747 of 747 are 99.33 pct identical to residues 1 to 747 of 747 from Escherichia coli K-12 Strain MG1655: B2503. (747 aa)
aerAerotaxis sensor receptor, flavoprotein; Residues 1 to 506 of 506 are 99.40 pct identical to residues 1 to 506 of 506 from Escherichia coli K-12 Strain MG1655: B3072. (506 aa)
yhdAOrf, hypothetical protein; Residues 1 to 646 of 646 are 99.53 pct identical to residues 1 to 646 of 646 from Escherichia coli K-12 Strain MG1655: B3252. (646 aa)
yhjHOrf, hypothetical protein; Residues 1 to 255 of 255 are 99.60 pct identical to residues 2 to 256 of 256 from Escherichia coli K-12 Strain MG1655: B3525. (255 aa)
yhjKOrf, hypothetical protein; Residues 1 to 651 of 651 are 99.23 pct identical to residues 1 to 651 of 651 from Escherichia coli K-12 Strain MG1655: B3529. (651 aa)
yjcCOrf, hypothetical protein; Residues 1 to 528 of 528 are 98.29 pct identical to residues 1 to 528 of 528 from Escherichia coli K-12 Strain MG1655: B4061. (528 aa)
Z5692Putative histidine kinase; Residues 389 to 752 of 756 are 43.60 pct identical to residues 286 to 663 of 671 from GenPept 118 : gi|5052340|gb|AAD38510.1|AF133262_2 (AF133262) histidine protein kinase-response regulator hybrid protein CvgSY [Pseudomonas syringae pv. syringae]. (756 aa)
Z5693Hypothetical protein; No significant matches. (58 aa)
tsrMethyl-accepting chemotaxis protein I, serine sensor receptor; Residues 1 to 554 of 554 are 98.55 pct identical to residues 1 to 551 of 551 from Escherichia coli K-12 Strain MG1655: B4355. (554 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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