STRINGSTRING
cutF cutF rcsF rcsF phoB phoB phoR phoR narL narL narX narX rstA rstA rstB rstB uvrY uvrY sdiA sdiA rcsA rcsA narP narP yojN yojN rcsB rcsB rcsC rcsC evgA evgA evgS evgS narQ narQ qseF qseF qseG qseG qseE qseE barA barA qseB qseB qseC qseC arcB arcB yrfF yrfF envZ envZ ompR ompR yhjB yhjB cpxA cpxA cpxR cpxR yiiO yiiO Z5684 Z5684 arcA arcA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cutFCopper homeostasis protein (lipoprotein); Residues 1 to 236 of 236 are 98.72 pct identical to residues 1 to 236 of 236 from Escherichia coli K-12 Strain MG1655: B0192. (236 aa)
rcsFRegulator in colanic acid synthesis; Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects; Belongs to the RcsF family. (134 aa)
phoBPositive response regulator for pho regulon, sensor is PhoR (or CreC); This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited (By similarity). (229 aa)
phoRPositive and negative sensor protein for pho regulon; Residues 1 to 431 of 431 are 99.07 pct identical to residues 1 to 431 of 431 from Escherichia coli K-12 Strain MG1655: B0400. (431 aa)
narLNitrate/nitrite response regulator protein NarL; This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal transmitted by either the NarX or NarQ proteins. (216 aa)
narXNitrate/nitrate sensor, histidine protein kinase acts on NarL regulator; Acts as a sensor for nitrate/nitrite and transduces signal of nitrate availability to the NarL protein and of both nitrate/nitrite to the NarP protein. NarX probably activates NarL and NarP by phosphorylation in the presence of nitrate. NarX also plays a negative role in controlling NarL activity, probably through dephosphorylation in the absence of nitrate (By similarity). (598 aa)
rstAResponse transcriptional regulatory protein (RstB sensor); Residues 1 to 242 of 242 are 99.58 pct identical to residues 1 to 242 of 242 from Escherichia coli K-12 Strain MG1655: B1608. (242 aa)
rstBSensor histidine protein kinase (RstA regulator); Residues 1 to 433 of 433 are 99.53 pct identical to residues 1 to 433 of 433 from Escherichia coli K-12 Strain MG1655: B1609. (433 aa)
uvrYPutative 2-component transcriptional regulator; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the effects of CsrA on csrB RNA by BarA-dependent and BarA-independent mechanisms (By similarity). (218 aa)
sdiATranscriptional regulator of ftsQAZ gene cluster; Residues 1 to 240 of 240 are 99.16 pct identical to residues 1 to 240 of 240 from Escherichia coli K-12 Strain MG1655: B1916. (240 aa)
rcsAPositive regulator for ctr capsule biosynthesis, positive transcription factor; Component of the Rcs signaling system, which controls transcription of numerous genes. Binds, with RcsB, to the RcsAB box to regulate expression of genes. (207 aa)
narPNitrate/nitrite response regulator (sensor NarQ); Residues 1 to 215 of 215 are 99.06 pct identical to residues 1 to 215 of 215 from Escherichia coli K-12 Strain MG1655: B2193. (215 aa)
yojNPutative 2-component sensor protein; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (890 aa)
rcsBPositive response regulator for colanic capsule biosynthesis, (sensor, RcsC); Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. (216 aa)
rcsCSensor for ctr capsule biosynthesis, probable histidine kinase acting on RcsB; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (933 aa)
evgAPutative positive transcription regulator (sensor EvgS); Member of the two-component regulatory system EvgS/EvgA. Regulates the expression of emrKY operon and yfdX. Seems also to control expression of at least one other multidrug efflux operon (By similarity). (204 aa)
evgSPutative sensor for regulator EvgA; Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals (By similarity). (1197 aa)
narQSensor for nitrate reductase system, protein histidine kinase (acts on NarP and narL); Residues 1 to 566 of 566 are 99.29 pct identical to residues 1 to 566 of 566 from Escherichia coli K-12 Strain MG1655: B2469. (566 aa)
qseFQuorum sensing regulator F; Member of the two-component regulatory system QseF/QseE involved in the regulation of virulence and metabolism in EHEC. Required for pedestal formation in host epithelial cells during infection. Regulates various metabolic and virulence genes, many iron- utilization genes and some two-component systems such as RcsB/RcsC and PhoP/PhoQ. Activates, indirectly, transcription of EspF(U) to induce pedestal formation. (444 aa)
qseGQuorum sensing regulator G; Involved in the regulation of virulence and metabolism in EHEC. Required for pedestal formation in host epithelial cells during infection. Necessary for translocation of effector molecules into host epithelial cells, but is not involved in structural assembly of the type III secretion system (TTSS). (237 aa)
qseEQuorum sensing regulator E; Member of the two-component regulatory system QseF/QseE involved in the regulation of virulence and metabolism in EHEC. Required for pedestal formation in host epithelial cells during infection. Autophosphorylates in response to epinephrine, sulfate or phosphate and then probably transfers its phosphate group to QseF. (496 aa)
barASensor-regulator, activates OmpR by phophorylation; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). (918 aa)
qseBQuorum sensing Escherichia coli regulator B; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. Currently it is not known whether this effect is direct or not. (219 aa)
qseCQuorum sensing Escherichia coli regulator C; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation. (449 aa)
arcBAerobic respiration sensor-response protein; Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His-717 and Asp-576 (By similarity). (778 aa)
yrfFPutative dehydrogenase; Residues 1 to 711 of 711 are 99.57 pct identical to residues 1 to 711 of 711 from Escherichia coli K-12 Strain MG1655: B3398. (711 aa)
envZProtein histidine kinase/phosphatase sensor for OmpR, modulates expression of ompF and ompC; Residues 1 to 450 of 450 are 99.77 pct identical to residues 1 to 450 of 450 from Escherichia coli K-12 Strain MG1655: B3404. (450 aa)
ompRDNA-binding dual transcriptional regulator OmpR; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes. Plays a central role in both acid and osmotic stress responses. Binds to the promoter of both ompC and ompF; at low osmolarity it activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription. (239 aa)
yhjBPutative regulator; Residues 1 to 200 of 200 are 99.50 pct identical to residues 1 to 200 of 200 from Escherichia coli K-12 Strain MG1655: B3520. (200 aa)
cpxAProbable sensor protein (histidine protein kinase), acting on arcA; This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synthesis, translocation, or stability of cell envelope proteins. Activates CpxR by phosphorylation (By similarity). (457 aa)
cpxRTranscriptional regulator in 2-component system; Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein (By similarity). (232 aa)
yiiOHypothetical protein; Residues 46 to 167 of 167 are 100.00 pct identical to residues 1 to 122 of 122 from Escherichia coli K-12 Strain MG1655: B3914. (167 aa)
Z5684Putative transcriptional regulator; Residues 9 to 240 of 241 are 41.52 pct identical to residues 2 to 234 of 238 from GenPept 118 : gi|152259|gb|AAA74221.1| (M38698) lcrB gene product [Rhizobium sp.]. (241 aa)
arcANegative response regulator of genes in aerobic pathways, (sensors, ArcB and CpxA); Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expression of genes of aerobic function. Activates the transcription of the plfB operon by binding to its promoter (By similarity). (238 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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