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nagE nagE hxpB hxpB fruA fruA fruK fruK fruB fruB yfbT yfbT fryA fryA ypdE ypdE ypdF ypdF fryC fryC fryB fryB ptsH ptsH ptsI ptsI crr crr ptsP ptsP cmtA cmtA cmtB cmtB ptsN ptsN ptsO ptsO mtlA mtlA mtlD mtlD frvR frvR frvX frvX frvB frvB frvA frvA ptsA ptsA frwC_1 frwC_1 frwC_2 frwC_2 frwB frwB frwD frwD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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nagEPTS system, N-acetylglucosamine-specific enzyme IIABC; Residues 1 to 648 of 648 are 99.53 pct identical to residues 1 to 648 of 648 from Escherichia coli K-12 Strain MG1655: B0679. (648 aa)
hxpBPutative phosphatase (YniC); Sugar-phosphate phosphohydrolase that catalyzes the dephosphorylation of D-mannitol 1-phosphate and D-sorbitol 6-phosphate. Also catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate (2dGlu6P); this is a biologically important activity in vivo since it contributes to the elimination of this toxic compound and plays an important role in the resistance of E.coli to 2-deoxyglucose. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (222 aa)
fruAPTS system, fructose-specific transport protein; Residues 1 to 563 of 563 are 99.46 pct identical to residues 1 to 563 of 563 from Escherichia coli K-12 Strain MG1655: B2167. (563 aa)
fruKFructose-1-phosphate kinase; Residues 1 to 312 of 312 are 100.00 pct identical to residues 1 to 312 of 312 from Escherichia coli K-12 Strain MG1655: B2168; Belongs to the carbohydrate kinase PfkB family. (312 aa)
fruBPTS system, fructose-specific IIA/fpr component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport. (376 aa)
yfbTPutative phosphatase; Residues 1 to 216 of 216 are 98.61 pct identical to residues 7 to 222 of 222 from Escherichia coli K-12 Strain MG1655: B2293. (216 aa)
fryAPutative PTS system enzyme IIA component, enzyme I; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport. (831 aa)
ypdEOrf, hypothetical protein; Residues 1 to 345 of 345 are 98.84 pct identical to residues 1 to 345 of 345 from Escherichia coli K-12 Strain MG1655: B2384. (345 aa)
ypdFPutative peptidase; Residues 1 to 361 of 361 are 96.12 pct identical to residues 1 to 361 of 361 from Escherichia coli K-12 Strain MG1655: B2385. (361 aa)
fryCPutative transport protein; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (415 aa)
fryBPutative PTS system enzyme IIB component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport. (108 aa)
ptsHPTS system protein HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. (85 aa)
ptsIPEP-protein phosphotransferase system enzyme I; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (575 aa)
crrPTS system, glucose-specific IIA component; Residues 1 to 169 of 169 are 99.40 pct identical to residues 1 to 169 of 169 from Escherichia coli K-12 Strain MG1655: B2417. (169 aa)
ptsPPTS system, enzyme I, transcriptional regulator (with NPR and NTR proteins); Residues 1 to 748 of 748 are 99.86 pct identical to residues 1 to 748 of 748 from Escherichia coli K-12 Strain MG1655: B2829; Belongs to the PEP-utilizing enzyme family. (748 aa)
cmtAPTS system, mannitol-specific enzyme II component, cryptic; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport. (462 aa)
cmtBPTS system, mannitol-specific enzyme II component, cryptic; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport. (147 aa)
ptsNPhosphotransferase system enzyme IIA, regulates N metabolism; Residues 1 to 163 of 163 are 99.38 pct identical to residues 1 to 163 of 163 from Escherichia coli K-12 Strain MG1655: B3204. (163 aa)
ptsOPhosphocarrier protein HPr-like NPr, nitrogen related, exchanges phosphate with Enzyme I, Hpr; Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein NPr by enzyme I-Ntr. Phospho-NPr then transfers it to EIIA-Ntr. Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins; Belongs [...] (90 aa)
mtlAPTS system, mannitol-specific enzyme IIABC components; Residues 1 to 637 of 637 are 99.37 pct identical to residues 1 to 637 of 637 from Escherichia coli K-12 Strain MG1655: B3599. (637 aa)
mtlDMannitol-1-phosphate dehydrogenase; Residues 1 to 382 of 382 are 98.42 pct identical to residues 1 to 382 of 382 from Escherichia coli K-12 Strain MG1655: B3600; Belongs to the mannitol dehydrogenase family. (382 aa)
frvRPutative frv operon regulatory protein; Residues 1 to 582 of 582 are 98.28 pct identical to residues 1 to 582 of 582 from Escherichia coli K-12 Strain MG1655: B3897. (582 aa)
frvXFrv operon protein; Residues 1 to 356 of 356 are 96.06 pct identical to residues 1 to 356 of 356 from Escherichia coli K-12 Strain MG1655: B3898. (356 aa)
frvBPTS system, fructose-like enzyme IIBC component; Residues 1 to 481 of 481 are 99.17 pct identical to residues 1 to 485 of 485 from Escherichia coli K-12 Strain MG1655: B3899. (481 aa)
frvAPTS system, fructose-specific IIA component; Residues 1 to 148 of 148 are 97.97 pct identical to residues 1 to 148 of 148 from Escherichia coli K-12 Strain MG1655: B3900. (148 aa)
ptsAPEP-protein phosphotransferase system enzyme I; Residues 1 to 711 of 711 are 99.57 pct identical to residues 1 to 711 of 711 from Escherichia coli K-12 Strain MG1655: B3947. (711 aa)
frwC_1Partial phosphotransferase system enzyme II component; Residues 1 to 246 of 246 are 100.00 pct identical to residues 1 to 246 of 359 from Escherichia coli K-12 Strain MG1655: B3949. (246 aa)
frwC_2Partial phosphotransferase system enzyme II component; Residues 1 to 106 of 106 are 99.05 pct identical to residues 254 to 359 of 359 from Escherichia coli K-12 Strain MG1655: B3949. (106 aa)
frwBPTS system fructose-like IIB component 1; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport. (106 aa)
frwDPTS system fructose-like IIB component 2; Residues 1 to 113 of 113 are 98.23 pct identical to residues 1 to 113 of 113 from Escherichia coli K-12 Strain MG1655: B3953. (113 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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