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thrB thrB thrC thrC dapB dapB dapD dapD aroL aroL aroG aroG ybiB ybiB aroA aroA aspC aspC pabC pabC trpE_1 trpE_1 trpE_2 trpE_2 trpD trpD trpC trpC trpB trpB trpA trpA ydiM ydiM ydiN ydiN ydiB ydiB aroD aroD aroH aroH pabB pabB hisL hisL hisG hisG hisD hisD hisC hisC hisB hisB hisH hisH hisA hisA hisF hisF hisI hisI aroC aroC dapE dapE dapA dapA pheA pheA tyrA tyrA aroF aroF argA argA lysA lysA argG argG aroE aroE argD argD pabA pabA aroB aroB aroK aroK asd asd yhhY yhhY dapF dapF metL metL argE argE argC argC argB argB argH argH lysC lysC tyrB tyrB
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa)
thrCThreonine synthase; Residues 1 to 428 of 428 are 99.76 pct identical to residues 1 to 428 of 428 from Escherichia coli K-12 Strain MG1655: B0004. (428 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
dapD2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Residues 1 to 274 of 274 are 99.63 pct identical to residues 1 to 274 of 274 from Escherichia coli K-12 Strain MG1655: B0166; Belongs to the transferase hexapeptide repeat family. (274 aa)
aroLShikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (174 aa)
aroG3-deoxy-D-arabinoheptulosonate-7-phosphate synthase (DAHP synthetase, phenylalanine repressible); Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (350 aa)
ybiBPutative enzyme; Residues 1 to 320 of 320 are 98.75 pct identical to residues 1 to 320 of 320 from Escherichia coli K-12 Strain MG1655: B0800. (320 aa)
aroA5-enolpyruvylshikimate-3-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa)
aspCAspartate aminotransferase; Residues 1 to 396 of 396 are 99.49 pct identical to residues 1 to 396 of 396 from Escherichia coli K-12 Strain MG1655: B0928. (396 aa)
pabC4-amino-4-deoxychorismate lyase; Residues 1 to 269 of 269 are 97.76 pct identical to residues 1 to 269 of 269 from Escherichia coli K-12 Strain MG1655: B1096. (269 aa)
trpE_1Anthranilate synthase component I; Residues 1 to 424 of 441 are 97.87 pct identical to residues 1 to 424 of 520 from GenPept 118 : gi|1787518|gb|AAC74346.1| (AE000224) anthranilate synthase component I [Escherichia coli]. (441 aa)
trpE_2Anthranilate synthase component I; Residues 1 to 86 of 86 are 100.00 pct identical to residues 435 to 520 of 520 from GenPept 118 : gi|1787518|gb|AAC74346.1| (AE000224) anthranilate synthase component I [Escherichia coli]. (86 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (531 aa)
trpCN-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity). (453 aa)
trpBTryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa)
trpATryptophan synthase, alpha protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa)
ydiMPutative transport system permease protein; Residues 1 to 404 of 404 are 99.00 pct identical to residues 1 to 404 of 404 from Escherichia coli K-12 Strain MG1655: B1690. (404 aa)
ydiNPutative amino acid/amine transport protein; Residues 1 to 423 of 423 are 99.29 pct identical to residues 1 to 423 of 423 from Escherichia coli K-12 Strain MG1655: B1691. (423 aa)
ydiBPutative oxidoreductase; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. (288 aa)
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (252 aa)
aroH3-deoxy-D-arabinoheptulosonate-7-phosphate synthase (DAHP synthetase, tryptophan repressible); Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (348 aa)
pabBP-aminobenzoate synthetase, component I; Residues 1 to 453 of 453 are 97.35 pct identical to residues 1 to 453 of 453 from Escherichia coli K-12 Strain MG1655: B1812. (453 aa)
hisLHis operon leader peptide; Residues 1 to 16 of 16 are 93.75 pct identical to residues 1 to 16 of 16 from Escherichia coli K-12 Strain MG1655: B2018. (16 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (299 aa)
hisDL-histidinal:NAD+ oxidoreductase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa)
hisCHistidinol-phosphate aminotransferase; Residues 1 to 356 of 356 are 99.43 pct identical to residues 1 to 356 of 356 from Escherichia coli K-12 Strain MG1655: B2021; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa)
hisBImidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase; Residues 1 to 356 of 356 are 99.43 pct identical to residues 1 to 356 of 356 from Escherichia coli K-12 Strain MG1655: B2022; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (356 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). (196 aa)
hisAN-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Residues 1 to 246 of 246 are 98.37 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 Strain MG1655: B2024; Belongs to the HisA/HisF family. (246 aa)
hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). (258 aa)
hisIPhosphoribosyl-amp cyclohydrolase; Residues 1 to 203 of 203 are 98.52 pct identical to residues 1 to 203 of 203 from Escherichia coli K-12 Strain MG1655: B2026; In the C-terminal section; belongs to the PRA-PH family. (203 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa)
dapEN-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
pheAChorismate mutase-P and prephenate dehydratase; Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. (386 aa)
tyrAChorismate mutase-T and prephenate dehydrogenase; Residues 1 to 373 of 373 are 99.46 pct identical to residues 1 to 373 of 373 from Escherichia coli K-12 Strain MG1655: B2600. (373 aa)
aroF3-deoxy-D-arabinoheptulosonate-7-phosphate synthase (DAHP synthetase, tyrosine repressible); Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (356 aa)
argAN-acetylglutamate synthase; Residues 1 to 443 of 443 are 100.00 pct identical to residues 1 to 443 of 443 from Escherichia coli K-12 Strain MG1655: B2818; Belongs to the acetyltransferase family. ArgA subfamily. (443 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa)
argGArgininosuccinate synthetase; Residues 1 to 447 of 447 are 99.77 pct identical to residues 1 to 447 of 447 from Escherichia coli K-12 Strain MG1655: B3172; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (447 aa)
aroEDehydroshikimate reductase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa)
argDAcetylornithine delta-aminotransferase; Involved in both the arginine and lysine biosynthetic pathways. (406 aa)
pabAP-aminobenzoate synthetase, component II; Residues 1 to 187 of 187 are 98.93 pct identical to residues 1 to 187 of 187 from Escherichia coli K-12 Strain MG1655: B3360. (187 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (362 aa)
aroKShikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (240 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (367 aa)
yhhYOrf, hypothetical protein; Residues 1 to 158 of 158 are 96.83 pct identical to residues 5 to 162 of 162 from Escherichia coli K-12 Strain MG1655: B3441. (158 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (275 aa)
metLAspartokinase II and homoserine dehydrogenase II; Residues 1 to 810 of 810 are 99.87 pct identical to residues 1 to 810 of 810 from Escherichia coli K-12 Strain MG1655: B3940; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa)
argEAcetylornithine deacetylase; Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde. (383 aa)
argCN-acetyl-gamma-glutamylphosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (258 aa)
argHArgininosuccinate lyase; Residues 1 to 457 of 457 are 98.68 pct identical to residues 1 to 457 of 457 from Escherichia coli K-12 Strain MG1655: B3960. (457 aa)
lysCAspartokinase III, lysine sensitive; Residues 1 to 449 of 449 are 99.77 pct identical to residues 1 to 449 of 449 from Escherichia coli K-12 Strain MG1655: B4024; Belongs to the aspartokinase family. (449 aa)
tyrBTyrosine aminotransferase, tyrosine repressible; Residues 1 to 397 of 397 are 98.48 pct identical to residues 1 to 397 of 397 from Escherichia coli K-12 Strain MG1655: B4054. (397 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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