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| | dedD | Putative lipoprotein; Non-essential cell division protein that could be required for efficient cell constriction. (220 aa) |
| | kefC | K+ efflux antiporter, glutathione-regulated; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (620 aa) |
| | ftsL | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (121 aa) |
| | ftsI | Septum formation; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (588 aa) |
| | ftsW | Cell division; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (414 aa) |
| | ftsQ | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (276 aa) |
| | yadQ | Putative channel transporter; Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response. (473 aa) |
| | ybdA | Putative transport; Component of an export pathway for enterobactin. Belongs to the major facilitator superfamily. EntS (TC 2.A.1.38) family. (416 aa) |
| | crcB | Orf, hypothetical protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. (127 aa) |
| | ybeC | Orf, hypothetical protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA; Belongs to the TatA/E family. TatE subfamily. (67 aa) |
| | mrdB | Rod shape-determining membrane protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (370 aa) |
| | mrdA | Cell elongation, e phase; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (633 aa) |
| | potE | Putrescine transport protein; Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. (439 aa) |
| | kdpC | High-affinity potassium transport system; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (190 aa) |
| | kdpB | ATPase of high-affinity potassium transport system, B chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (682 aa) |
| | kdpA | ATPase of high-affinity potassium transport system, A chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (557 aa) |
| | ybgH | Putative transport protein; Probable proton-dependent permease that transports dipeptides. (493 aa) |
| | tolQ | Inner membrane protein, membrane-spanning, maintains integrity of cell envelope; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (230 aa) |
| | tolR | Putative inner membrane protein, involved in the tonB-independent uptake of group A colicins; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (142 aa) |
| | yceE | Hypothetical protein; Confers resistance to fosfomycin and deoxycholate. Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily. (355 aa) |
| | lpxL | Hypothetical protein; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa) |
| | mviN | Putative virulence factor; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (511 aa) |
| | yceG | Putative thymidylate kinase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (340 aa) |
| | emrE | Methylviologen resistance protein encoded within prophage CP-933X; Residues 1 to 110 of 110 are 98.18 pct identical to residues 1 to 110 of 110 from GenPept 118 : gi|1786755|gb|AAC73644.1| (AE000160) methylviologen resistance [Escherichia coli]. (110 aa) |
| | nhaP2 | Orf, hypothetical protein; K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily. (536 aa) |
| | chaA | Sodium-calcium/proton antiporter; Residues 1 to 366 of 366 are 99.72 pct identical to residues 1 to 366 of 366 from Escherichia coli K-12 Strain MG1655: B1216. (366 aa) |
| | yciB | Orf, hypothetical protein; Involved in cell division; probably involved in intracellular septation; Belongs to the YciB family. (179 aa) |
| | yciS | Orf, hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. (102 aa) |
| | mdtI | Possible chaperone; Catalyzes the excretion of spermidine. (109 aa) |
| | mdtJ | Possible chaperone; Catalyzes the excretion of spermidine. (121 aa) |
| | ydgR | Putative transport protein; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily. (500 aa) |
| | sppA | Protease IV, a signal peptide peptidase; Residues 1 to 618 of 618 are 99.19 pct identical to residues 1 to 618 of 618 from Escherichia coli K-12 Strain MG1655: B1766. (618 aa) |
| | yeaL | Orf, hypothetical protein; Residues 1 to 148 of 148 are 99.32 pct identical to residues 1 to 148 of 148 from Escherichia coli K-12 Strain MG1655: B1789. (148 aa) |
| | msbB | Suppressor of htrB, heat shock protein; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (323 aa) |
| | yebI | Orf, hypothetical protein; Residues 1 to 261 of 261 are 98.85 pct identical to residues 1 to 261 of 261 from Escherichia coli K-12 Strain MG1655: B1859. (261 aa) |
| | tyrP | Tyrosine-specific transport system; Residues 1 to 403 of 403 are 99.75 pct identical to residues 1 to 403 of 403 from Escherichia coli K-12 Strain MG1655: B1907. (403 aa) |
| | msrQ | Orf, hypothetical protein; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. MsrQ prov [...] (211 aa) |
| | yegB | Putative transport protein; Residues 1 to 471 of 471 are 98.93 pct identical to residues 1 to 471 of 471 from Escherichia coli K-12 Strain MG1655: B2077. (471 aa) |
| | yohM | Orf, hypothetical protein; Efflux system for nickel and cobalt. (283 aa) |
| | dld | D-lactate dehydrogenase, FAD protein, NADH independent; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (571 aa) |
| | lpxT | Orf, hypothetical protein; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (249 aa) |
| | yojN | Putative 2-component sensor protein; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (890 aa) |
| | rcsC | Sensor for ctr capsule biosynthesis, probable histidine kinase acting on RcsB; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (933 aa) |
| | arnE | Hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. (111 aa) |
| | arnF | Hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. (222 aa) |
| | yfcJ | Putative transport protein; Residues 1 to 392 of 392 are 98.72 pct identical to residues 1 to 392 of 392 from Escherichia coli K-12 Strain MG1655: B2322. (392 aa) |
| | ddg | Putative heat shock protein; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (328 aa) |
| | zipA | Cell division protein involved in FtsZ ring; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. (328 aa) |
| | cysZ | Required for sulfate transport; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (253 aa) |
| | alaE | Orf, hypothetical protein; Exports L-alanine; Belongs to the AlaE exporter family. (149 aa) |
| | ftsB | Orf, hypothetical protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (103 aa) |
| | lgt | Phosphatidylglycerol-prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (291 aa) |
| | nupG | Transport of nucleosides, permease protein; Broad-specificity transporter of purine and pyrimidine nucleosides. Driven by a proton motive force; Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family. (434 aa) |
| | yqjB | Orf, hypothetical protein; Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. (127 aa) |
| | mtr | Tryptophan-specific transport protein; Residues 1 to 414 of 414 are 99.51 pct identical to residues 1 to 414 of 414 from Escherichia coli K-12 Strain MG1655: B3161. (414 aa) |
| | yrbG | Orf, hypothetical protein; Residues 1 to 325 of 325 are 99.69 pct identical to residues 1 to 325 of 325 from Escherichia coli K-12 Strain MG1655: B3196. (325 aa) |
| | yrbK | Orf, hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. (191 aa) |
| | nanT | Sialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. (506 aa) |
| | mscL | Mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. (136 aa) |
| | kefB | K+ efflux; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (592 aa) |
| | damX | Putative membrane protein; Non-essential cell division protein. (428 aa) |
| | ugpE | Sn-glycerol 3-phosphate transport system, integral membrane protein; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane. (281 aa) |
| | yhhQ | Orf, hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (221 aa) |
| | yhhS | Putative transport; Residues 1 to 419 of 419 are 99.04 pct identical to residues 1 to 419 of 419 from Escherichia coli K-12 Strain MG1655: B3473. (419 aa) |
| | yhiP | Putative transport protein; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily. (489 aa) |
| | yiaH | Orf, hypothetical protein; Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units. (331 aa) |
| | lldP | L-lactate permease; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force (By similarity). (551 aa) |
| | tnaB | Low affinity tryptophan permease; Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically (By similarity); Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily. (415 aa) |
| | pstA | High-affinity phosphate-specific transport system; Residues 1 to 296 of 296 are 99.66 pct identical to residues 1 to 296 of 296 from Escherichia coli K-12 Strain MG1655: B3726. (296 aa) |
| | rfe | UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (367 aa) |
| | wzzE | Putative transport protein; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA). (349 aa) |
| | wzxE | Putative cytochrome; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. (416 aa) |
| | wecF | TDP-Fuc4NAc:lipidII transferase; Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units; Belongs to the WzyE family. (450 aa) |
| | rarD | Orf, hypothetical protein; Residues 4 to 295 of 295 are 92.12 pct identical to residues 8 to 299 of 300 from Escherichia coli K-12 Strain MG1655: B3819. (295 aa) |
| | tatA | Twin arginine translocation protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (103 aa) |
| | tatB | Hypothetical protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (145 aa) |
| | tatC | Putative integral membrane protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (258 aa) |
| | rbn | tRNA processing exoribonuclease BN; Residues 1 to 290 of 290 are 100.00 pct identical to residues 1 to 290 of 290 from Escherichia coli K-12 Strain MG1655: B3886. (290 aa) |
| | menA | 1,4-dihydroxy-2-naphthoate --> dimethylmenaquinone; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. (308 aa) |
| | ftsN | Essential cell division protein; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. (319 aa) |
| | yjcG | Putative transport protein; Transports acetate; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (549 aa) |
| | phnE | Membrane channel protein component of Pn transporter; Residues 1 to 157 of 276 are 99.36 pct identical to residues 1 to 157 of 206 from Escherichia coli K-12 Strain MG1655: B4104. (276 aa) |
| | sugE | Suppresses groEL, may be chaperone; Guanidinium ion exporter. Couples guanidinium export to the proton motive force, exchanging one guanidinium ion for two protons. Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Gdx/SugE subfamily. (155 aa) |
| | ytfN | Orf, hypothetical protein; Residues 1 to 1259 of 1259 are 98.80 pct identical to residues 1 to 1259 of 1259 from Escherichia coli K-12 Strain MG1655: B4221. (1259 aa) |
