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nhaP2 nhaP2 yaaJ yaaJ caiT caiT kefC kefC yabJ yabJ abc abc lacY lacY afuC afuC cyoC cyoC cyoB cyoB cyoA cyoA ybaR ybaR gltL gltL potE potE kdpC kdpC kdpB kdpB kdpA kdpA ybgH ybgH modC modC putP putP potA potA nhaB nhaB ychM ychM ydgR ydgR yebM yebM fliI fliI fruA fruA yeiO yeiO Z3623 Z3623 cysA cysA cysW cysW cysU cysU fucP fucP ygeD ygeD eivC eivC nupG nupG nanT nanT kefB kefB ugpC ugpC zntA zntA nikD nikD nikE nikE yhiP yhiP gltS gltS escN escN pstB pstB atpD atpD atpA atpA trkH trkH frvB frvB kdgT kdgT yjbB yjbB gltP gltP mgtA mgtA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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nhaP2Orf, hypothetical protein; K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily. (536 aa)
yaaJInner membrane transport protein; Residues 1 to 476 of 476 are 99.15 pct identical to residues 1 to 476 of 476 from Escherichia coli K-12 Strain MG1655: B0007. (476 aa)
caiTProbable carnitine transporter; Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines. (504 aa)
kefCK+ efflux antiporter, glutathione-regulated; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (620 aa)
yabJPutative ATP-binding component of a transport system; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family. (232 aa)
abcATP-binding component of a transporter; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (343 aa)
lacYGalactoside permease (M protein); Residues 1 to 417 of 417 are 99.76 pct identical to residues 1 to 417 of 417 from Escherichia coli K-12 Strain MG1655: B0343. (417 aa)
afuCPutative ATP-binding component of a transport system; Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system. (352 aa)
cyoCCytochrome o ubiquinol oxidase subunit III; Residues 1 to 204 of 204 are 99.50 pct identical to residues 1 to 204 of 204 from Escherichia coli K-12 Strain MG1655: B0430. (204 aa)
cyoBCytochrome o ubiquinol oxidase subunit I; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity). (663 aa)
cyoACytochrome o ubiquinol oxidase subunit II; Residues 1 to 315 of 315 are 99.04 pct identical to residues 1 to 315 of 315 from Escherichia coli K-12 Strain MG1655: B0432. (315 aa)
ybaRPutative ATPase; [Copper-exporting P-type ATPase]: Involved in Cu(+) export (By similarity). (834 aa)
gltLATP-binding protein of glutamate/aspartate transport system; Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for energy coupling to the transport system. (241 aa)
potEPutrescine transport protein; Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. (439 aa)
kdpCHigh-affinity potassium transport system; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (190 aa)
kdpBATPase of high-affinity potassium transport system, B chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (682 aa)
kdpAATPase of high-affinity potassium transport system, A chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (557 aa)
ybgHPutative transport protein; Probable proton-dependent permease that transports dipeptides. (493 aa)
modCATP-binding component of molybdate transport; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. (352 aa)
putPMajor sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (502 aa)
potAATP-binding component of spermidine/putrescine transport; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (378 aa)
nhaBNa+/H+ antiporter, pH independent; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family. (513 aa)
ychMOrf, hypothetical protein; Responsible for the aerobic transport of succinate from the periplasm to the cytoplasm at acidic pH; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (550 aa)
ydgRPutative transport protein; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily. (500 aa)
yebMPutative ATP-binding component of a transport system; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. (251 aa)
fliIFlagellum-specific ATP synthase; Residues 40 to 496 of 496 are 100.00 pct identical to residues 1 to 457 of 457 from Escherichia coli K-12 Strain MG1655: B1941. (496 aa)
fruAPTS system, fructose-specific transport protein; Residues 1 to 563 of 563 are 99.46 pct identical to residues 1 to 563 of 563 from Escherichia coli K-12 Strain MG1655: B2167. (563 aa)
yeiOPutative transport; Residues 1 to 393 of 393 are 99.23 pct identical to residues 1 to 393 of 393 from Escherichia coli K-12 Strain MG1655: B2170. (393 aa)
Z3623Sucrose permease; Residues 1 to 415 of 415 are 99.51 pct identical to residues 1 to 415 of 415 from GenPept 118 : gi|41168|emb|CAA45274.1| (X63740) sucrose permease [Escherichia coli]. (415 aa)
cysAATP-binding component of sulfate permease A protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (365 aa)
cysWSulfate/thiosulfate transport system permease W protein; Residues 1 to 149 of 149 are 99.32 pct identical to residues 1 to 149 of 149 from Escherichia coli K-12 Strain MG1655: B2423. (149 aa)
cysUSulfate, thiosulfate transport system permease T protein; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (277 aa)
fucPFucose permease; Residues 1 to 438 of 438 are 99.77 pct identical to residues 1 to 438 of 438 from Escherichia coli K-12 Strain MG1655: B2801. (438 aa)
ygeDPutative resistance proteins; Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell; Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family. (397 aa)
eivCType III secretion apparatus protein; Residues 10 to 396 of 439 are 63.30 pct identical to residues 1 to 386 of 432 from GenPept 118 : gi|497222|gb|AAA74038.1| (U08279) invC [Salmonella typhimurium]. (439 aa)
nupGTransport of nucleosides, permease protein; Broad-specificity transporter of purine and pyrimidine nucleosides. Driven by a proton motive force; Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family. (434 aa)
nanTSialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. (506 aa)
kefBK+ efflux; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (592 aa)
ugpCATP-binding component of sn-glycerol 3-phosphate transport system; Part of the ABC transporter complex UgpABCE involved in sn- glycerol-3-phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. sn-glycerol-3- phosphate importer (TC 3.A.1.1.3) family. (369 aa)
zntAZinc-transporting ATPase; Residues 1 to 732 of 732 are 98.90 pct identical to residues 1 to 732 of 732 from Escherichia coli K-12 Strain MG1655: B3469. (732 aa)
nikDATP-binding protein of nickel transport system; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (254 aa)
nikEATP-binding protein of nickel transport system; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (268 aa)
yhiPPutative transport protein; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily. (489 aa)
gltSGlutamate transport; Catalyzes the sodium-dependent transport of glutamate. Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family. (401 aa)
escNescN; Residues 1 to 446 of 446 are 100.00 pct identical to residues 1 to 446 of 446 from GenPept 118 : gi|3414902|gb|AAC31513.1| (AF071034) L0034 [Escherichia coli]. (446 aa)
pstBATP-binding component of high-affinity phosphate-specific transport system; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (257 aa)
atpDMembrane-bound ATP synthase, F1 sector, beta-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (460 aa)
atpAMembrane-bound ATP synthase, F1 sector, alpha-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (513 aa)
trkHPotassium uptake protein, requires TrkE; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA and requires TrkE for transport activity (By similarity); Belongs to the TrkH potassium transport family. (483 aa)
frvBPTS system, fructose-like enzyme IIBC component; Residues 1 to 481 of 481 are 99.17 pct identical to residues 1 to 485 of 485 from Escherichia coli K-12 Strain MG1655: B3899. (481 aa)
kdgT2-keto-3-deoxy-D-gluconate transport system; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity); Belongs to the KdgT transporter family. (330 aa)
yjbBPutative alpha helix protein; Residues 1 to 543 of 543 are 99.44 pct identical to residues 1 to 543 of 543 from Escherichia coli K-12 Strain MG1655: B4020. (543 aa)
gltPGlutamate-aspartate symport protein; Catalyzes the proton-dependent transport of glutamate and aspartate; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. GltP subfamily. (437 aa)
mgtAMg2+ transport ATPase, P-type 1; Mediates magnesium influx to the cytosol; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily. (898 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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