STRINGSTRING
prmA prmA map map Z0462 Z0462 phoR phoR ppiB ppiB ybcZ ybcZ ylcB ylcB entD entD citA citA lipA lipA lipB lipB kdpD kdpD nleH1-1 nleH1-1 espX2 espX2 yliG yliG rimK rimK yccC yccC yccY yccY torS torS acpS2 acpS2 cobB cobB espX7 espX7 phoQ phoQ hemK hemK narX narX nleG2-3 nleG2-3 nleG6-2 nleG6-2 nleG5-2 nleG5-2 ynbD ynbD nleG5-1 nleG5-1 nleG6-1 nleG6-1 nleG2-2 nleG2-2 rstB rstB ydiA ydiA cheB cheB cheR cheR cheA cheA yedK yedK yedV yedV wzc wzc wzb wzb yegI yegI baeS baeS yehU yehU ccmE ccmE yojL yojL rcsC rcsC arnT arnT evgS evgS ypdA ypdA narQ narQ qseE qseE acpS acpS nleG8-2 nleG8-2 hypF hypF pcm pcm barA barA qseC qseC arcB arcB ppiA ppiA envZ envZ acpT acpT uhpB uhpB yieE yieE hemC hemC yihE yihE glnL glnL cpxA cpxA hydH hydH Z5692 Z5692 basS basS yjdH yjdH yjeA yjeA rimI rimI lplA lplA creC creC nleG nleG nleH1_2 nleH1_2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
prmAMethylase for 50S ribosomal subunit protein L11; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. (293 aa)
mapMethionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (264 aa)
Z0462Putative sensor kinase; Residues 9 to 505 of 513 are 35.75 pct identical to residues 11 to 496 of 500 from GenPept 118 : gi|154409|gb|AAA27244.1| (M89480) hexosephosphate transport protein [Salmonella typhimurium]. (513 aa)
phoRPositive and negative sensor protein for pho regulon; Residues 1 to 431 of 431 are 99.07 pct identical to residues 1 to 431 of 431 from Escherichia coli K-12 Strain MG1655: B0400. (431 aa)
ppiBPeptidyl-prolyl cis-trans isomerase B (rotamase B); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
ybcZPutative 2-component sensor protein; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. (482 aa)
ylcBPutative resistance protein; Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver (By similarity); Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. (460 aa)
entDEnterobactin synthetase component D; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'-phosphopantetheine (Ppant) moiety from coenzyme A to the apo- domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-fo [...] (209 aa)
citAPutative sensor-type protein; Residues 1 to 552 of 552 are 99.63 pct identical to residues 1 to 552 of 552 from Escherichia coli K-12 Strain MG1655: B0619. (552 aa)
lipALipoate synthesis, sulfur insertion; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa)
lipBLipoate biosynthesis protein B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (191 aa)
kdpDSensor for high-affinity potassium transport system; Residues 1 to 894 of 894 are 99.55 pct identical to residues 1 to 894 of 894 from Escherichia coli K-12 Strain MG1655: B0695. (894 aa)
nleH1-1Unknown protein encoded by prophage CP-933K; No significant matches. (293 aa)
espX2Hypothetical protein; Residues 373 to 669 of 670 are 24.50 pct identical to residues 495 to 781 of 782 from GenPept 118 : gi|5669806|gb|AAD46479.1|AF121227_1 (AF121227) secreted effector protein [Salmonella dublin]. (670 aa)
yliGOrf, hypothetical protein; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (441 aa)
rimKRibosomal protein S6 modification protein; Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF). Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate. The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH. Belongs to the RimK family. (300 aa)
yccCOrf, hypothetical protein; Residues 1 to 726 of 726 are 99.86 pct identical to residues 1 to 726 of 726 from Escherichia coli K-12 Strain MG1655: B0981. (726 aa)
yccYPutative phosphatase; Dephosphorylates etk; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (152 aa)
torSSensor protein torS (regulator TorR); Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Detects the presence of TMAO in the medium and, in response, activates TorR via a four-step phosphorelay. When TMAO is removed, TorS can dephosphorylate TorR, probably by a reverse phosphorelay involving His- 860 and Asp-733 (By similarity). (904 aa)
acpS2Putative acyl-carrier protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of an acyl-carrier-protein (By similarity). This isozyme may be involved into a specific lipid biosynthetic pathway that also includes Z1545, Z1546 and Z1547; Belongs to the P-Pant transferase superfamily. AcpS family. (122 aa)
cobBPutative nicotinic acid mononucleotide:5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. (273 aa)
espX7Unknown protein encoded by prophage CP-933N; Residues 62 to 648 of 649 are 31.14 pct identical to residues 184 to 781 of 782 from GenPept 118 : gi|5669806|gb|AAD46479.1|AF121227_1 (AF121227) secreted effector protein [Salmonella dublin]. (649 aa)
phoQSensor protein PhoQ; Member of the two-component regulatory system PhoP/PhoQ involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, which results in the repression of PG and may l [...] (460 aa)
hemKPossible protoporphyrinogen oxidase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (277 aa)
narXNitrate/nitrate sensor, histidine protein kinase acts on NarL regulator; Acts as a sensor for nitrate/nitrite and transduces signal of nitrate availability to the NarL protein and of both nitrate/nitrite to the NarP protein. NarX probably activates NarL and NarP by phosphorylation in the presence of nitrate. NarX also plays a negative role in controlling NarL activity, probably through dephosphorylation in the absence of nitrate (By similarity). (598 aa)
nleG2-3Hypothetical protein; Residues 72 to 187 of 191 are 34.18 pct identical to residues 20 to 136 of 140 from GenPept 118 : gi|4126792|dbj|BAA36750.1| (AB016764) ORF4 [Escherichia coli]. (191 aa)
nleG6-2Hypothetical protein; Residues 72 to 206 of 209 are 91.11 pct identical to residues 1 to 135 of 140 from GenPept 118 : gi|4126792|dbj|BAA36750.1| (AB016764) ORF4 [Escherichia coli]. (209 aa)
nleG5-2Hypothetical protein; Residues 80 to 210 of 213 are 43.51 pct identical to residues 8 to 136 of 140 from GenPept 118 : gi|4126792|dbj|BAA36750.1| (AB016764) ORF4 [Escherichia coli]. (213 aa)
ynbDPutative enzymes; Residues 1 to 430 of 430 are 95.81 pct identical to residues 1 to 430 of 430 from Escherichia coli K-12 Strain MG1655: B1411. (430 aa)
nleG5-1Unknown protein encoded by prophage CP-933R; Residues 80 to 210 of 213 are 41.98 pct identical to residues 8 to 136 of 140 from GenPept 118 : gi|4126792|dbj|BAA36750.1| (AB016764) ORF4 [Escherichia coli]. (213 aa)
nleG6-1Unknown protein encoded by prophage CP-933R; Residues 72 to 206 of 209 are 91.11 pct identical to residues 1 to 135 of 140 from GenPept 118 : gi|4126792|dbj|BAA36750.1| (AB016764) ORF4 [Escherichia coli]. (209 aa)
nleG2-2Unknown protein encoded by prophage CP-933R; Residues 72 to 187 of 191 are 35.04 pct identical to residues 20 to 136 of 140 from GenPept 118 : gi|4126792|dbj|BAA36750.1| (AB016764) ORF4 [Escherichia coli]. (191 aa)
rstBSensor histidine protein kinase (RstA regulator); Residues 1 to 433 of 433 are 99.53 pct identical to residues 1 to 433 of 433 from Escherichia coli K-12 Strain MG1655: B1609. (433 aa)
ydiAOrf, hypothetical protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (277 aa)
cheBResponse regulator for chemotaxis (cheA sensor); Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (349 aa)
cheRResponse regulator for chemotaxis; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (286 aa)
cheASensory transducer kinase between chemo- signal receptors and CheB and CheY; Residues 1 to 654 of 654 are 99.38 pct identical to residues 1 to 654 of 654 from Escherichia coli K-12 Strain MG1655: B1888. (654 aa)
yedKOrf, hypothetical protein; Residues 1 to 214 of 222 are 98.13 pct identical to residues 1 to 214 of 217 from Escherichia coli K-12 Strain MG1655: B1931; Belongs to the SOS response-associated peptidase family. (222 aa)
yedVPutative 2-component sensor protein; Member of a two-component regulatory system. (452 aa)
wzcOrf, hypothetical protein; Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg (By similarity); Belongs to the etk/wzc family. (732 aa)
wzbProbable protein-tyrosine-phosphatase; Dephosphorylates Wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium. Involved in protection of cells against contact-dependent growth inhibition (CDI). (147 aa)
yegIPutative chaperonin; Probable serine/threonine kinase. (646 aa)
baeSSensor protein (for BaeR); Residues 1 to 467 of 467 are 99.35 pct identical to residues 1 to 467 of 467 from Escherichia coli K-12 Strain MG1655: B2078. (467 aa)
yehUPutative 2-component sensor protein; Residues 1 to 561 of 561 are 99.64 pct identical to residues 1 to 561 of 561 from Escherichia coli K-12 Strain MG1655: B2126. (561 aa)
ccmECytochrome c biogenesis, possible subunit of a heme lyase; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (159 aa)
yojLOrf, hypothetical protein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein such as NqrB and NqrC, two subunits of the NQR complex; Belongs to the ApbE family. (351 aa)
rcsCSensor for ctr capsule biosynthesis, probable histidine kinase acting on RcsB; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (933 aa)
arnTOrf, hypothetical protein; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family. (550 aa)
evgSPutative sensor for regulator EvgA; Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals (By similarity). (1197 aa)
ypdAPutative sensor protein; Member of the two-component regulatory system YpdA/YpdB. YpdA activates YpdB by phosphorylation in response to high concentrations of extracellular pyruvate. (565 aa)
narQSensor for nitrate reductase system, protein histidine kinase (acts on NarP and narL); Residues 1 to 566 of 566 are 99.29 pct identical to residues 1 to 566 of 566 from Escherichia coli K-12 Strain MG1655: B2469. (566 aa)
qseEQuorum sensing regulator E; Member of the two-component regulatory system QseF/QseE involved in the regulation of virulence and metabolism in EHEC. Required for pedestal formation in host epithelial cells during infection. Autophosphorylates in response to epinephrine, sulfate or phosphate and then probably transfers its phosphate group to QseF. (496 aa)
acpSCoA:apo-[acyl-carrier-protein] pantetheinephosphotransferase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to the 'Ser-36' of acyl-carrier-protein. (126 aa)
nleG8-2Hypothetical protein; Residues 1 to 216 of 216 are 99.53 pct identical to residues 1 to 216 of 216 from GenPept 118 : gi|4126790|dbj|BAA36748.1| (AB016764) ORF2 [Escherichia coli]. (216 aa)
hypFTranscriptional regulatory protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (750 aa)
pcmL-isoaspartate protein carboxylmethyltransferase type II; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins (By similarity). Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family. (208 aa)
barASensor-regulator, activates OmpR by phophorylation; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). (918 aa)
qseCQuorum sensing Escherichia coli regulator C; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation. (449 aa)
arcBAerobic respiration sensor-response protein; Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His-717 and Asp-576 (By similarity). (778 aa)
ppiAPeptidyl-prolyl cis-trans isomerase A (rotamase A); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). (190 aa)
envZProtein histidine kinase/phosphatase sensor for OmpR, modulates expression of ompF and ompC; Residues 1 to 450 of 450 are 99.77 pct identical to residues 1 to 450 of 450 from Escherichia coli K-12 Strain MG1655: B3404. (450 aa)
acpTHypothetical protein; May be involved in an alternative pathway for phosphopantetheinyl transfer and holo-ACP synthesis in E.coli. The native apo-protein substrate is unknown. Is able to functionally replace AcpS in vivo but only when expressed at high levels. Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family. (195 aa)
uhpBSensor histidine protein kinase phosphorylates UhpA; Residues 1 to 501 of 501 are 99.20 pct identical to residues 1 to 501 of 501 from Escherichia coli K-12 Strain MG1655: B3668. (501 aa)
yieEOrf, hypothetical protein; Residues 1 to 253 of 253 are 99.20 pct identical to residues 1 to 253 of 253 from Escherichia coli K-12 Strain MG1655: B3712. (253 aa)
hemCPorphobilinogen deaminase = hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (320 aa)
yihEOrf, hypothetical protein; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (328 aa)
glnLHistidine protein kinase sensor for GlnG regulator (nitrogen regulator II, NRII); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC. In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC. (349 aa)
cpxAProbable sensor protein (histidine protein kinase), acting on arcA; This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synthesis, translocation, or stability of cell envelope proteins. Activates CpxR by phosphorylation (By similarity). (457 aa)
hydHSensor kinase for HydG, hydrogenase 3 activity; Member of the two-component regulatory system ZraS/ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium (By similarity). (458 aa)
Z5692Putative histidine kinase; Residues 389 to 752 of 756 are 43.60 pct identical to residues 286 to 663 of 671 from GenPept 118 : gi|5052340|gb|AAD38510.1|AF133262_2 (AF133262) histidine protein kinase-response regulator hybrid protein CvgSY [Pseudomonas syringae pv. syringae]. (756 aa)
basSSensor protein for basR; Residues 1 to 363 of 363 are 99.17 pct identical to residues 1 to 363 of 363 from Escherichia coli K-12 Strain MG1655: B4112. (363 aa)
yjdHPutative 2-component sensor protein; Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4- dicarboxylate transporter dctA. Activates DcuR by phosphorylation (By similarity). (543 aa)
yjeAPutative lysyl-tRNA synthetase; With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF- P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)-beta- lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF- P 'Lys-34'; Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily. (335 aa)
rimIAcyltransferase for 30S ribosomal subunit protein S18; Acetylates the N-terminal alanine of ribosomal protein S18. (148 aa)
lplAPutative lipoate-protein ligase A; Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. (562 aa)
creCCatabolite repression sensor kinase for PhoB; Residues 1 to 474 of 474 are 98.52 pct identical to residues 1 to 474 of 474 from Escherichia coli K-12 Strain MG1655: B4399. (474 aa)
nleGOrf, hypothetical protein; Residues 1 to 206 of 215 are 63.59 pct identical to residues 1 to 206 of 216 from Genpept121: dbj|BAA36748.1| (AB016764) ORF2 [Escherichia coli]. (215 aa)
nleH1_2Orf, hypothetical protein; Residues 121 to 218 of 303 are 23.46 pct identical to residues 23 to 120 of 232 from Genpept121: emb|CAB72961.1| (AL139076) putative flagellar L-ring protein precursor [Campylobacter jejuni]. (303 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.