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fliO fliO fliN fliN fliM fliM fliL fliL fliK fliK fliJ fliJ fliH fliH fliG fliG fliF fliF fliE fliE fliD fliD fliC fliC motA motA motB motB cheY cheY flhB flhB flhA flhA flhE flhE ydeQ ydeQ ydeR ydeR ydeS ydeS Orf-11 Orf-11 ycgR ycgR espN espN flgI flgI flgH flgH flgG flgG flgF flgF flgE flgE flgC flgC flgB flgB ymdA ymdA csgA csgA csgB csgB Z1538 Z1538 Z1535 Z1535 ycbV ycbV ycbU ycbU elfG elfG ycbQ ycbQ ybgD ybgD ybgO ybgO sfmF sfmF sfmH sfmH sfmA sfmA espY3 espY3 yahD yahD yagZ yagZ yagW yagW mbhA mbhA yadN yadN yadM yadM yadL yadL yadK yadK yadD yadD ppdD ppdD espY1 espY1 Z0024 Z0024 fmlA fmlA yraH yraH epaO epaO escR-2 escR-2 eprS eprS ppdC ppdC yfcV yfcV yfcR yfcR yfcQ yfcQ yfcP yfcP yfcI yfcI yfaD yfaD yehD yehD yehA yehA fliR fliR fliQ fliQ fliP fliP rpnD rpnD fimH fimH fimG fimG fimF fimF fimI fimI fimA fimA yjbI yjbI lpfA-2 lpfA-2 lpfD-3 lpfD-3 lpfD-2 lpfD-2 escR escR lpfA lpfA lpfD lpfD lpfE lpfE yhgA yhgA Z4504 Z4504
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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fliOFlagelar biosynthesis; Residues 1 to 101 of 101 are 100.00 pct identical to residues 1 to 101 of 101 from Escherichia coli K-12 Strain MG1655: B1947. (101 aa)
fliNFlagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family. (137 aa)
fliMFlagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. (334 aa)
fliLFlagellar biosynthesis; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family. (154 aa)
fliKFlagellar hook-length control protein; Residues 1 to 375 of 375 are 98.40 pct identical to residues 1 to 375 of 375 from Escherichia coli K-12 Strain MG1655: B1943. (375 aa)
fliJFlagellar fliJ protein; Flagellar protein that affects chemotactic events. Belongs to the FliJ family. (147 aa)
fliHFlagellar biosynthesis; Residues 1 to 235 of 235 are 99.14 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 Strain MG1655: B1940. (235 aa)
fliGFlagellar motor switch protein FliG; FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity). (331 aa)
fliFFlagellar biosynthesis; The M ring may be actively involved in energy transduction. Belongs to the FliF family. (552 aa)
fliEFlagellar biosynthesis; Residues 1 to 104 of 104 are 100.00 pct identical to residues 1 to 104 of 104 from Escherichia coli K-12 Strain MG1655: B1937. (104 aa)
fliDFlagellar biosynthesis; Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity). (465 aa)
fliCFlagellar biosynthesis; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (585 aa)
motAProton conductor component of motor; Residues 1 to 295 of 295 are 99.32 pct identical to residues 1 to 295 of 295 from Escherichia coli K-12 Strain MG1655: B1890. (295 aa)
motBEnables flagellar motor rotation, linking torque machinery to cell wall; MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity). (308 aa)
cheYChemotaxis regulator transmits chemoreceptor signals to flagelllar motor components; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation (By similarity). (129 aa)
flhBPutative part of export apparatus for flagellar proteins; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (382 aa)
flhAFlagellar biosynthesis; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (692 aa)
flhEFlagellar protein; Residues 1 to 130 of 130 are 97.69 pct identical to residues 1 to 130 of 130 from Escherichia coli K-12 Strain MG1655: B1878. (130 aa)
ydeQPutative adhesin; Residues 1 to 304 of 304 are 98.35 pct identical to residues 1 to 304 of 304 from Escherichia coli K-12 Strain MG1655: B1502. (304 aa)
ydeRPutative fimbrial-like protein; Residues 1 to 167 of 167 are 98.20 pct identical to residues 1 to 167 of 167 from Escherichia coli K-12 Strain MG1655: B1503. (167 aa)
ydeSPutative fimbrial-like protein; Residues 1 to 176 of 176 are 99.43 pct identical to residues 1 to 176 of 176 from Escherichia coli K-12 Strain MG1655: B1504. (176 aa)
Orf-11Orf; Residues 1 to 165 of 174 are 98.18 pct identical to residues 10 to 174 of 429 from GenPept 118 : gi|606085|gb|AAA57948.1| (U18997) ORF_o429; overlaps o863, other starts possible [Escherichia coli]. (174 aa)
ycgRHypothetical protein; Residues 1 to 198 of 198 are 97.47 pct identical to residues 1 to 198 of 244 from Escherichia coli K-12 Strain MG1655: B1194. (198 aa)
espNUnknown protein encoded by prophage CP-933N; Residues 691 to 934 of 937 are 31.29 pct identical to residues 471 to 709 of 1014 from GenPept 118 : gi|476080|gb|AAA18229.1| (U01097) cytotoxic necrotizing factor type 2 [Escherichia coli]. (937 aa)
flgIHomolog of Salmonella P-ring of flagella basal body; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (365 aa)
flgHFlagellar biosynthesis, basal-body outer-membrane L (lipopolysaccharide layer) ring protein; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (232 aa)
flgGFlagellar biosynthesis, cell-distal portion of basal-body rod; Residues 1 to 260 of 260 are 100.00 pct identical to residues 1 to 260 of 260 from Escherichia coli K-12 Strain MG1655: B1078; Belongs to the flagella basal body rod proteins family. (260 aa)
flgFFlagellar biosynthesis, cell-proximal portion of basal-body rod; Residues 1 to 251 of 251 are 99.60 pct identical to residues 1 to 251 of 251 from Escherichia coli K-12 Strain MG1655: B1077. (251 aa)
flgEFlagellar biosynthesis, hook protein; Residues 1 to 401 of 401 are 94.77 pct identical to residues 1 to 402 of 402 from Escherichia coli K-12 Strain MG1655: B1076. (401 aa)
flgCFlagellar biosynthesis, cell-proximal portion of basal-body rod; Residues 1 to 134 of 134 are 100.00 pct identical to residues 1 to 134 of 134 from Escherichia coli K-12 Strain MG1655: B1074; Belongs to the flagella basal body rod proteins family. (134 aa)
flgBFlagellar biosynthesis, cell-proximal portion of basal-body rod; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body. (138 aa)
ymdAOrf, hypothetical protein; Residues 1 to 103 of 103 are 98.05 pct identical to residues 1 to 103 of 103 from Escherichia coli K-12 Strain MG1655: B1044. (103 aa)
csgACurlin major subunit, coiled surface structures; Curlin is the structural subunit of the curli. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin; Belongs to the CsgA/CsgB family. (152 aa)
csgBMinor curlin subunit precursor, similar ro CsgA; Curlin is the structural subunit of the curli. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers (By similarity); Belongs to the CsgA/CsgB family. (151 aa)
Z1538Putative pilin subunit; Residues 1 to 185 of 186 are 36.36 pct identical to residues 1 to 175 of 176 from GenPept 118 : gi|4106624|emb|CAA21379.1| (AL031866) ORF56, len=176 aa, similar to pilin precursor F17d-A, eg. Q57228 E. coli,(181 aa). (186 aa)
Z1535Hypothetical protein; Residues 7 to 444 of 444 are 34.58 pct identical to residues 25 to 449 of 449 from GenPept 118 : gi|4106627|emb|CAA21382.1| (AL031866) ORF59, len=449 aa, some similarity with pilin, Haemophilus influenzae hifA, (213 aa), 27.8% identity in 187 aa overlap. (444 aa)
ycbVPutative fimbrial-like protein; Residues 1 to 187 of 187 are 99.46 pct identical to residues 1 to 187 of 187 from Escherichia coli K-12 Strain MG1655: B0943. (187 aa)
ycbUHypothetical protein; Residues 1 to 158 of 158 are 100.00 pct identical to residues 23 to 180 of 180 from Escherichia coli K-12 Strain MG1655: B0942. (158 aa)
elfGHomolog of Salmonella FimH protein; Part of the elfADCG fimbrial operon, which could be required for adherence to host epithelial cells. (326 aa)
ycbQPutative fimbrial-like protein; Part of the elfADCG fimbrial operon, which could be required for adherence to host epithelial cells. ElfA is an accessory colonization factor that contributes to adherence of bacteria to human intestinal epithelial cells and to animal intestinal tissue in vitro. Binds specifically to laminin, but not to fibronectin or collagen type IV. (182 aa)
ybgDPutative fimbriae structural protein; Residues 1 to 188 of 188 are 79.25 pct identical to residues 1 to 188 of 188 from Escherichia coli K-12 Strain MG1655: B0719. (188 aa)
ybgOHypothetical protein; Residues 1 to 353 of 353 are 87.81 pct identical to residues 10 to 362 of 362 from Escherichia coli K-12 Strain MG1655: B0716. (353 aa)
sfmFPutative fimbrial protein; Residues 1 to 171 of 171 are 97.66 pct identical to residues 1 to 171 of 171 from Escherichia coli K-12 Strain MG1655: B0534. (171 aa)
sfmHInvolved in fimbrial asembly; Residues 1 to 325 of 325 are 99.38 pct identical to residues 1 to 325 of 325 from Escherichia coli K-12 Strain MG1655: B0533. (325 aa)
sfmAPutative fimbrial-like protein; Residues 1 to 191 of 191 are 100.00 pct identical to residues 1 to 191 of 191 from Escherichia coli K-12 Strain MG1655: B0530. (191 aa)
espY3Hypothetical protein; Residues 173 to 335 of 523 are 27.54 pct identical to residues 124 to 287 of 295 from GenPept 118 : gi|886362|gb|AAA69501.1| (L42525) product unknown; 32 kd ORF [Plasmid pSW200]. (523 aa)
yahDPutative transcription factor; Residues 1 to 201 of 201 are 99.50 pct identical to residues 1 to 201 of 201 from Escherichia coli K-12 Strain MG1655: B0318. (201 aa)
yagZOrf, hypothetical protein; Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Major subunit of the fimbria. (195 aa)
yagWPutative receptor; Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Tip pilus adhesin, which is required for assembly of EcpA into fibers (By similarity); Belongs to the EcpD/MatE family. (547 aa)
mbhAPutative motility protein; Residues 1 to 261 of 261 are 99.23 pct identical to residues 1 to 261 of 261 from Escherichia coli K-12 Strain MG1655: B0230. (261 aa)
yadNPutative fimbrial protein; Residues 7 to 201 of 201 are 39.50 pct identical to residues 8 to 194 of 194 from Escherichia coli K-12 Strain MG1655: B0141. (201 aa)
yadMPutative fimbrial protein; Residues 14 to 186 of 186 are 49.44 pct identical to residues 26 to 203 of 203 from Escherichia coli K-12 Strain MG1655: B0138. (186 aa)
yadLPutative fimbrial protein; Residues 9 to 200 of 201 are 41.14 pct identical to residues 11 to 200 of 201 from Escherichia coli K-12 Strain MG1655: B0137. (201 aa)
yadKPutative fimbrial protein; Residues 7 to 196 of 196 are 40.10 pct identical to residues 11 to 198 of 198 from Escherichia coli K-12 Strain MG1655: B0136. (196 aa)
yadDOrf, hypothetical protein; Residues 1 to 298 of 298 are 96.97 pct identical to residues 1 to 298 of 300 from Escherichia coli K-12 Strain MG1655: B0132. (298 aa)
ppdDPrelipin peptidase dependent protein; Residues 1 to 146 of 146 are 99.31 pct identical to residues 1 to 146 of 146 from Escherichia coli K-12 Strain MG1655: B0108. (146 aa)
espY1Hypothetical protein; Residues 1 to 192 of 250 are 87.50 pct identical to residues 1 to 192 of 216 from Escherichia coli K-12 Strain MG1655: B0056. (250 aa)
Z0024Putative type-1 fimbrial protein; Residues 1 to 177 of 177 are 26.66 pct identical to residues 1 to 180 of 180 from GenPept 118 : gi|1788429|gb|AAC75172.1| (AE000300) putative fimbrial-like protein [Escherichia coli]. (177 aa)
fmlAPutative major fimbrial subunit; Residues 1 to 186 of 187 are 64.70 pct identical to residues 1 to 181 of 182 from GenPept 118 : gi|1790769|gb|AAC77270.1| (AE000502) major type 1 subunit fimbrin (pilin) [Escherichia coli]. (187 aa)
yraHPutative fimbrial-like protein; Residues 1 to 194 of 194 are 94.32 pct identical to residues 1 to 194 of 194 from Escherichia coli K-12 Strain MG1655: B3142. (194 aa)
epaOtypeIII secretion apparatus protein; Residues 35 to 326 of 328 are 32.44 pct identical to residues 23 to 301 of 303 from GenPept 118 : gi|973281|gb|AAC43947.1| (U29351) SpaO [Salmonella enterica]. (328 aa)
escR-2Putative integral membrane protein-component of typeIII secretion apparatus; Residues 1 to 218 of 221 are 69.05 pct identical to residues 1 to 223 of 224 from GenPept 118 : gi|975759|gb|AAC43849.1| (U29360) SpaP [Salmonella enterica]. (221 aa)
eprSPutative integral membrane protein-component of type III secretion apparatus; Residues 2 to 349 of 373 are 54.44 pct identical to residues 3 to 350 of 356 from GenPept 118 : gi|404293|emb|CAA51927.1| (X73525) surface presentation of antigens [Salmonella typhimurium]. (373 aa)
ppdCPrepilin peptidase dependent protein C; Residues 1 to 107 of 107 are 98.13 pct identical to residues 1 to 107 of 107 from Escherichia coli K-12 Strain MG1655: B2823. (107 aa)
yfcVPutative major fimbrial subunit; Residues 1 to 187 of 187 are 88.77 pct identical to residues 1 to 187 of 187 from Escherichia coli K-12 Strain MG1655: B2339. (187 aa)
yfcRPutative minor fimbrial subunit; Residues 32 to 197 of 197 are 47.59 pct identical to residues 6 to 170 of 170 from Escherichia coli K-12 Strain MG1655: B2335. (197 aa)
yfcQPutative minor fimbrial subunit; Residues 19 to 156 of 156 are 53.19 pct identical to residues 22 to 162 of 162 from Escherichia coli K-12 Strain MG1655: B2334. (156 aa)
yfcPPutative minor fimbrial subunit; Residues 1 to 172 of 173 are 56.89 pct identical to residues 5 to 178 of 179 from Escherichia coli K-12 Strain MG1655: B2333. (173 aa)
yfcIOrf, hypothetical protein; Residues 1 to 296 of 296 are 95.60 pct identical to residues 1 to 296 of 296 from Escherichia coli K-12 Strain MG1655: B2305. (296 aa)
yfaDOrf, hypothetical protein; Residues 1 to 303 of 308 are 94.05 pct identical to residues 1 to 295 of 299 from Escherichia coli K-12 Strain MG1655: B2244. (308 aa)
yehDPutative fimbrial-like protein; Residues 1 to 180 of 180 are 85.55 pct identical to residues 1 to 180 of 180 from Escherichia coli K-12 Strain MG1655: B2111. (180 aa)
yehAPutative fimbrial protein; Residues 138 to 344 of 344 are 44.76 pct identical to residues 141 to 344 of 344 from GenPept 118 : gi|1788426|gb|AAC75169.1| (AE000300) putative type-1 fimbrial protein [Escherichia coli]. (344 aa)
fliRFlagellar biosynthesis; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (261 aa)
fliQFlagellar biosynthesis; Required for the assembly of the rivet at the earliest stage of flagellar biosynthesis; Belongs to the FliQ/MopD/SpaQ family. (89 aa)
fliPFlagellar biosynthesis; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (245 aa)
rpnDHypothetical protein; A low activity DNA endonuclease probably yielding 3'-hydroxyl ends. Involved in RecA-independent recombination and horizontal gene transfer (By similarity). (260 aa)
fimHMinor fimbrial subunit, D-mannose specific adhesin; Residues 1 to 300 of 300 are 99.33 pct identical to residues 1 to 300 of 300 from Escherichia coli K-12 Strain MG1655: B4320. (300 aa)
fimGFimbrial morphology; Residues 1 to 167 of 167 are 98.80 pct identical to residues 1 to 167 of 167 from Escherichia coli K-12 Strain MG1655: B4319. (167 aa)
fimFFimbrial morphology; Residues 1 to 176 of 176 are 99.43 pct identical to residues 1 to 176 of 176 from Escherichia coli K-12 Strain MG1655: B4318. (176 aa)
fimIFimbrial protein; Residues 1 to 215 of 215 are 98.60 pct identical to residues 1 to 215 of 215 from Escherichia coli K-12 Strain MG1655: B4315. (215 aa)
fimAMajor type 1 subunit fimbrin (pilin); Residues 1 to 182 of 182 are 96.70 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 Strain MG1655: B4314. (182 aa)
yjbIHypothetical protein; Residues 86 to 526 of 526 are 88.66 pct identical to residues 2 to 442 of 442 from Escherichia coli K-12 Strain MG1655: B4038. (526 aa)
lpfA-2Putative major fimbrial subuit; Residues 1 to 198 of 200 are 31.27 pct identical to residues 1 to 184 of 185 from GenPept 118 : gi|913907|gb|AAB33536.1| (S76043) FimA=SEF21 type 1 structural fimbrin [Salmonella enteritidis, 27655-3b, Peptide, 185 aa]. (200 aa)
lpfD-3Putative fimbrial protein; Residues 3 to 354 of 356 are 25.75 pct identical to residues 14 to 355 of 356 from GenPept 118 : gi|1787173|gb|AAC74027.1| (AE000196) homolog of Salmonella FimH protein [Escherichia coli]. (356 aa)
lpfD-2Putative fimbrial protein; Residues 22 to 358 of 360 are 27.90 pct identical to residues 29 to 355 of 356 from GenPept 118 : gi|1787173|gb|AAC74027.1| (AE000196) homolog of Salmonella FimH protein [Escherichia coli]. (360 aa)
escRescR; Residues 1 to 217 of 217 are 100.00 pct identical to residues 1 to 217 of 217 from GenPept 118 : gi|3414917|gb|AAC31528.1| (AF071034) L0049 [Escherichia coli]. (217 aa)
lpfAPutative major fimbrial subunit; Part of the lpfABCC'DE fimbrial operon. LP fimbriae may participate in the interaction with eukaryotic cells by assisting in microcolony formation. (178 aa)
lpfDPutative fimbrial protein; Part of the lpfABCC'DE fimbrial operon. LP fimbriae may participate in the interaction with eukaryotic cells by assisting in microcolony formation. (351 aa)
lpfEPutative fimbrial subunit; Part of the lpfABCC'DE fimbrial operon. LP fimbriae may participate in the interaction with eukaryotic cells by assisting in microcolony formation. (176 aa)
yhgAOrf, hypothetical protein; Residues 1 to 292 of 292 are 98.97 pct identical to residues 1 to 292 of 292 from Escherichia coli K-12 Strain MG1655: B3411. (292 aa)
Z4504Partial putative fimbrial protein; Residues 26 to 163 of 163 are 99.27 pct identical to residues 226 to 363 of 363 from Escherichia coli K-12 Strain MG1655: B3145. (163 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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