STRINGSTRING
Z5212 Z5212 Z3940 Z3940 Z3945 Z3945 hfq hfq Z5213 Z5213 ygeK ygeK ygaG ygaG yqeI yqeI rpoS rpoS qseE qseE Z2973 Z2973 Z2969 Z2969 intT intT Z0326 Z0326 hha hha qseC qseC eivF eivF escR-2 escR-2 etrA etrA grlA grlA grlR grlR escU escU rpoA rpoA qseA qseA kdpE kdpE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Z5212Hypothetical protein; No significant matches. (223 aa)
Z3940Hypothetical protein; No significant matches. (156 aa)
Z3945Hypothetical protein; Residues 172 to 336 of 347 are 28.57 pct identical to residues 125 to 264 of 311 from GenPept 118 : gi|2621988|gb|AAB85391.1| (AE000865) integrase-recombinase protein [Methanobacterium thermoautotrophicum]. (347 aa)
hfqHost factor I for bacteriophage Q beta replication, a growth-related protein; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (102 aa)
Z5213Hypothetical protein; No significant matches. (141 aa)
ygeKPutative 2-component transcriptional regulator; Residues 1 to 148 of 148 are 100.00 pct identical to residues 1 to 148 of 148 from Escherichia coli K-12 Strain MG1655: B2855. (148 aa)
ygaGOrf, hypothetical protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
yqeIPutative sensory transducer; Residues 1 to 268 of 269 are 98.88 pct identical to residues 1 to 268 of 269 from Escherichia coli K-12 Strain MG1655: B2847. (269 aa)
rpoSRNA polymerase, sigma S (sigma38) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa)
qseEQuorum sensing regulator E; Member of the two-component regulatory system QseF/QseE involved in the regulation of virulence and metabolism in EHEC. Required for pedestal formation in host epithelial cells during infection. Autophosphorylates in response to epinephrine, sulfate or phosphate and then probably transfers its phosphate group to QseF. (496 aa)
Z2973Unknown protein encoded by prophage CP-933T; No significant matches. (80 aa)
Z2969Unknown protein encoded by prophage CP-933T; Residues 6 to 107 of 134 are 32.40 pct identical to residues 8 to 115 of 123 from GenPept 118 : gi|7226247|gb|AAF41408.1| (AE002452) transcriptional regulator [Neisseria meningitidis MC58]. (134 aa)
intTIntegrase for prophage CP-933T; Residues 1 to 331 of 333 are 57.86 pct identical to residues 1 to 334 of 337 from GenPept 118 : gi|1679807|emb|CAA96221.1| (Z71579) integrase [Bacteriophage S2]. (333 aa)
Z0326Unknown protein encoded in prophage CP-933I; No significant matches. (205 aa)
hhaHaemolysin expression modulating protein; Down-regulates hemolysin expression, in complex with H-NS, and can also stimulate transposition events in vivo. Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex. Binds DNA and influences DNA topology in response to environmental stimuli. Decreases biofilm formation (By similarity); Belongs to the Hha/YmoA/Cnu family. (72 aa)
qseCQuorum sensing Escherichia coli regulator C; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation. (449 aa)
eivFPutative regulatory protein for type III secretion apparatus; Residues 46 to 245 of 249 are 40.39 pct identical to residues 8 to 207 of 216 from GenPept 118 : gi|497224|gb|AAA74039.1| (U08280) invF [Salmonella typhimurium]. (249 aa)
escR-2Putative integral membrane protein-component of typeIII secretion apparatus; Residues 1 to 218 of 221 are 69.05 pct identical to residues 1 to 223 of 224 from GenPept 118 : gi|975759|gb|AAC43849.1| (U29360) SpaP [Salmonella enterica]. (221 aa)
etrAHypothetical protein; No significant matches. (166 aa)
grlAHypothetical protein; Residues 1 to 137 of 137 are 100.00 pct identical to residues 1 to 137 of 137 from GenPept 118 : gi|3414911|gb|AAC31522.1| (AF071034) L0043 [Escherichia coli]. (137 aa)
grlRHypothetical protein; Residues 1 to 123 of 123 are 100.00 pct identical to residues 1 to 123 of 123 from GenPept 118 : gi|3414912|gb|AAC31523.1| (AF071034) L0044 [Escherichia coli]. (123 aa)
escUescU; Residues 1 to 345 of 345 are 100.00 pct identical to residues 1 to 345 of 345 from GenPept 118 : gi|3414914|gb|AAC31525.1| (AF071034) L0046 [Escherichia coli]. (345 aa)
rpoARNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa)
qseAQuorum sensing Escherichia coli regulator A; Activates transcription of the aaeXAB operon. (309 aa)
kdpERegulator of kdp operon (transcriptional effector); Residues 1 to 225 of 225 are 98.66 pct identical to residues 1 to 225 of 225 from Escherichia coli K-12 Strain MG1655: B0694. (225 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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