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dcuB dcuB Z0461 Z0461 Z0462 Z0462 Z0463 Z0463 cydB cydB hcr hcr pflB pflB fdnG fdnG sdaA sdaA mglC mglC glpT glpT nuoJ nuoJ nuoI nuoI eutH eutH sdaC sdaC sdaB sdaB fucO fucO fucA fucA fucP fucP cmtB cmtB tdcE tdcE tdcD tdcD agaY agaY agaB agaB mdh mdh tufA tufA fusA fusA glpD glpD Z4875 Z4875 Z4876 Z4876 dctA dctA xylA xylA xylF xylF tnaA tnaA fdoG fdoG glpK glpK glpF glpF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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dcuBAnaerobic dicarboxylate transport; Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane; Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family. (446 aa)
Z0461Putative permease; Residues 8 to 422 of 434 are 53.25 pct identical to residues 20 to 434 of 440 from GenPept 118 : gi|2367260|gb|AAC76690.1| (AE000444) regulator of uhpT [Escherichia coli]. (434 aa)
Z0462Putative sensor kinase; Residues 9 to 505 of 513 are 35.75 pct identical to residues 11 to 496 of 500 from GenPept 118 : gi|154409|gb|AAA27244.1| (M89480) hexosephosphate transport protein [Salmonella typhimurium]. (513 aa)
Z0463Putative response regulator; Residues 1 to 202 of 209 are 49.00 pct identical to residues 1 to 194 of 196 from GenPept 118 : gi|154408|gb|AAA27243.1| (M89480) hexosephosphate utilization protein [Salmonella typhimurium]. (209 aa)
cydBCytochrome d terminal oxidase polypeptide subunit II; A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton/electron. (379 aa)
hcrPutative enzyme; Residues 1 to 322 of 322 are 98.75 pct identical to residues 1 to 322 of 322 from Escherichia coli K-12 Strain MG1655: B0872. (322 aa)
pflBFormate acetyltransferase 1; Residues 1 to 760 of 760 are 99.47 pct identical to residues 1 to 760 of 760 from Escherichia coli K-12 Strain MG1655: B0903. (760 aa)
fdnGFormate dehydrogenase-N, nitrate-inducible, alpha subunit; Residues 1 to 1015 of 1015 are 99.70 pct identical to residues 1 to 1015 of 1015 from Escherichia coli K-12 Strain MG1655: B1474. (1015 aa)
sdaAL-serine deaminase; Residues 1 to 454 of 454 are 99.77 pct identical to residues 1 to 454 of 454 from Escherichia coli K-12 Strain MG1655: B1814; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa)
mglCMethyl-galactoside transport and galactose taxis; Residues 1 to 336 of 336 are 99.70 pct identical to residues 1 to 336 of 336 from Escherichia coli K-12 Strain MG1655: B2148; Belongs to the binding-protein-dependent transport system permease family. (336 aa)
glpTSn-glycerol-3-phosphate permease; Residues 1 to 452 of 452 are 99.11 pct identical to residues 1 to 452 of 452 from Escherichia coli K-12 Strain MG1655: B2240. (452 aa)
nuoJNADH dehydrogenase I chain J; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity); Belongs to the complex I subunit 6 family. (184 aa)
nuoINADH dehydrogenase I chain I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (180 aa)
eutHEthanolamine utilization; Residues 1 to 408 of 408 are 99.50 pct identical to residues 1 to 408 of 408 from Escherichia coli K-12 Strain MG1655: B2452. (408 aa)
sdaCProbable serine transporter; Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity (By similarity). (429 aa)
sdaBL-serine dehydratase (deaminase), L-SD2; Residues 1 to 455 of 455 are 99.56 pct identical to residues 1 to 455 of 455 from Escherichia coli K-12 Strain MG1655: B2797; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa)
fucOL-1,2-propanediol oxidoreductase; Residues 1 to 383 of 383 are 100.00 pct identical to residues 1 to 383 of 383 from Escherichia coli K-12 Strain MG1655: B2799. (383 aa)
fucAL-fuculose-1-phosphate aldolase; Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. (215 aa)
fucPFucose permease; Residues 1 to 438 of 438 are 99.77 pct identical to residues 1 to 438 of 438 from Escherichia coli K-12 Strain MG1655: B2801. (438 aa)
cmtBPTS system, mannitol-specific enzyme II component, cryptic; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport. (147 aa)
tdcEProbable formate acetyltransferase 3; Residues 1 to 741 of 764 are 99.86 pct identical to residues 1 to 741 of 746 from Escherichia coli K-12 Strain MG1655: B3114. (764 aa)
tdcDPutative kinase; Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. (406 aa)
agaYTagatose-bisphosphate aldolase 2; Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires KbaZ subunit for full activity and stability. (286 aa)
agaBPTS system, cytoplasmic, N-acetylgalactosamine-specific IIB component 1 (EIIB-AGA); Residues 1 to 158 of 158 are 99.36 pct identical to residues 1 to 158 of 158 from Escherichia coli K-12 Strain MG1655: B3138. (158 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
tufAProtein chain elongation factor EF-Tu (duplicate of tufB); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (394 aa)
fusAGTP-binding protein chain elongation factor EF-G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation [...] (704 aa)
glpDSn-glycerol-3-phosphate dehydrogenase (aerobic); Residues 1 to 501 of 501 are 98.80 pct identical to residues 1 to 501 of 501 from Escherichia coli K-12 Strain MG1655: B3426; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (501 aa)
Z4875Putative phosphotransferase system enzyme subunit; Residues 1 to 151 of 157 are 33.98 pct identical to residues 1 to 152 of 160 from GenPept 118 : gi|4512375|dbj|BAA75339.1| (AB011837) phosphotransferase system (PTS) fructose-specific enzyme IIBC component [Bacillus halodurans]. (157 aa)
Z4876Putative phosphotransferase system enzyme subunit; Residues 1 to 92 of 93 are 35.48 pct identical to residues 1 to 93 of 94 from GenPept 118 : gi|1788409|gb|AAC75154.1| (AE000298) galactitol-specific enzyme IIB of phosphotransferase system [Escherichia coli]. (93 aa)
dctAUptake of C4-dicarboxylic acids; Responsible for the aerobic transport of the dicarboxylates fumarate and malate and to a lesser extent succinate, from the periplasm across the inner membrane; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (428 aa)
xylAD-xylose isomerase; Residues 1 to 440 of 440 are 99.54 pct identical to residues 1 to 440 of 440 from Escherichia coli K-12 Strain MG1655: B3565; Belongs to the xylose isomerase family. (440 aa)
xylFXylose binding protein transport system; Residues 1 to 330 of 330 are 99.39 pct identical to residues 1 to 330 of 330 from Escherichia coli K-12 Strain MG1655: B3566. (330 aa)
tnaATryptophanase; Residues 1 to 476 of 476 are 99.78 pct identical to residues 1 to 476 of 476 from Escherichia coli K-12 Strain MG1655: B3708; Belongs to the beta-eliminating lyase family. (476 aa)
fdoGFormate dehydrogenase-O, major subunit; Residues 1 to 1016 of 1016 are 99.51 pct identical to residues 1 to 1016 of 1016 from Escherichia coli K-12 Strain MG1655: B3894. (1016 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (509 aa)
glpFFacilitated diffusion of glycerol; Transporter of glycerol across the cytoplasmic membrane, with limited permeability to water and small uncharged compounds such as polyols. (281 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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