STRINGSTRING
iha iha fiu fiu kdpE kdpE nagC nagC sfmH sfmH Z0377 Z0377 eutQ eutQ eutP eutP hmpA hmpA ygaG ygaG norV norV eutE eutE pta pta fruB fruB fliC fliC ompF ompF lrp lrp ybjW ybjW qseC qseC fimH fimH yjeB yjeB nrfA nrfA ler ler eae eae espA espA hdeA hdeA hdeB hdeB nirB nirB eutK eutK fryA fryA eutI eutI
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ihaPutative receptor; Residues 1 to 696 of 696 are 99.85 pct identical to residues 1 to 696 of 696 from GenPept 118 : gi|7108480|gb|AAF36432.1|AF126104_1 (AF126104) adhesin [Escherichia coli O157:H7]. (696 aa)
fiuPutative outer membrane receptor for iron transport; Involved in the active transport across the outer membrane of iron complexed with catecholate siderophores such as dihydroxybenzoylserine and dihydroxybenzoate. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB. Can also transport catechol-substituted cephalosporins. Receptor for microcins M, H47 and E492 (By similarity). (760 aa)
kdpERegulator of kdp operon (transcriptional effector); Residues 1 to 225 of 225 are 98.66 pct identical to residues 1 to 225 of 225 from Escherichia coli K-12 Strain MG1655: B0694. (225 aa)
nagCTranscriptional repressor of nag (N-acetylglucosamine) operon; Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon. (406 aa)
sfmHInvolved in fimbrial asembly; Residues 1 to 325 of 325 are 99.38 pct identical to residues 1 to 325 of 325 from Escherichia coli K-12 Strain MG1655: B0533. (325 aa)
Z0377Putative dehydrogenase; Residues 11 to 291 of 294 are 46.61 pct identical to residues 8 to 285 of 286 from GenPept 118 : gi|4981536|gb|AAD36074.1|AE001762_1 (AE001762) oxidoreductase, aldo/keto reductase family [Thermotoga maritima]. (294 aa)
eutQOrf, hypothetical protein; Residues 1 to 233 of 233 are 98.71 pct identical to residues 1 to 233 of 233 from Escherichia coli K-12 Strain MG1655: B2460. (233 aa)
eutPOrf, hypothetical protein; Residues 1 to 159 of 159 are 98.11 pct identical to residues 1 to 159 of 159 from Escherichia coli K-12 Strain MG1655: B2461; Belongs to the EutP/PduV family. (159 aa)
hmpADihydropteridine reductase, ferrisiderophore reductase activity; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. (396 aa)
ygaGOrf, hypothetical protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
norVPutative flavodoxin; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center. Also able to function as an aerobic oxygen reductase (By similarity). (411 aa)
eutEEthanolamine utilization; Residues 1 to 467 of 467 are 99.57 pct identical to residues 1 to 467 of 467 from Escherichia coli K-12 Strain MG1655: B2455. (467 aa)
ptaPhosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (714 aa)
fruBPTS system, fructose-specific IIA/fpr component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport. (376 aa)
fliCFlagellar biosynthesis; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (585 aa)
ompFOuter membrane protein 1a (Ia;b;F); Residues 1 to 362 of 362 are 99.44 pct identical to residues 1 to 362 of 362 from Escherichia coli K-12 Strain MG1655: B0929; Belongs to the Gram-negative porin family. (362 aa)
lrpRegulator for leucine (or lrp) regulon and high-affinity branched-chain amino acid transport system; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes (By similarity). (164 aa)
ybjWPutative prismane; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (552 aa)
qseCQuorum sensing Escherichia coli regulator C; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation. (449 aa)
fimHMinor fimbrial subunit, D-mannose specific adhesin; Residues 1 to 300 of 300 are 99.33 pct identical to residues 1 to 300 of 300 from Escherichia coli K-12 Strain MG1655: B4320. (300 aa)
yjeBOrf, hypothetical protein; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. (141 aa)
nrfAPeriplasmic cytochrome c(552): plays a role in nitrite reduction; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (478 aa)
lerHypothetical protein; Residues 1 to 129 of 129 are 100.00 pct identical to residues 1 to 129 of 129 from GenPept 118 : gi|3414922|gb|AAC31533.1| (AF071034) L0054 [Escherichia coli]. (129 aa)
eaeIntimin adherence protein; Necessary for the production of attaching and effacing lesions on tissue culture cells; Belongs to the intimin/invasin family. (934 aa)
espASecreted protein EspA; Residues 1 to 192 of 192 are 100.00 pct identical to residues 1 to 192 of 192 from GenPept 118 : gi|3414890|gb|AAC31501.1| (AF071034) L0022 [Escherichia coli]. (192 aa)
hdeAOrf, hypothetical protein; Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Belongs to the HdeA family. (110 aa)
hdeBOrf, hypothetical protein; Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins. Belongs to the HdeB family. (112 aa)
nirBNitrite reductase (NAD(P)H) subunit; Residues 1 to 847 of 847 are 99.76 pct identical to residues 1 to 847 of 847 from Escherichia coli K-12 Strain MG1655: B3365; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (847 aa)
eutKOrf, hypothetical protein; Residues 1 to 168 of 168 are 98.80 pct identical to residues 1 to 168 of 168 from Escherichia coli K-12 Strain MG1655: B2438. (168 aa)
fryAPutative PTS system enzyme IIA component, enzyme I; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport. (831 aa)
eutIEthanolamine utilization; Residues 1 to 338 of 338 are 99.70 pct identical to residues 1 to 338 of 338 from Escherichia coli K-12 Strain MG1655: B2458. (338 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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