STRINGSTRING
Orf-12 Orf-12 mazG mazG mdh mdh Orf-13 Orf-13 waaJ waaJ waaI waaI dinD dinD gyrB gyrB purA purA pinH pinH adk adk bioC bioC icdA icdA ompC-2 ompC-2 ydgD ydgD fumC fumC gatD gatD ompC ompC pdxB pdxB recA recA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Orf-12Orf; Residues 1 to 76 of 94 are 40.78 pct identical to residues 64 to 139 of 158 from GenPept 118 : gi|2078067|emb|CAB08500.1| (Z95210) hypothetical protein Rv0918 [Mycobacterium tuberculosis]. (94 aa)
mazGOrf, hypothetical protein; Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazE-MazF toxin- antitoxin (TA) system that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA (By similarity); Belongs to the nucleoside triphosphate py [...] (263 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
Orf-13Orf; Residues 2 to 155 of 161 are 39.61 pct identical to residues 3 to 154 of 166 from GenPept 118 : gi|2078068|emb|CAB08501.1| (Z95210) hypothetical protein Rv0919 [Mycobacterium tuberculosis]. (161 aa)
waaJPutative LPS biosynthesis enzyme; Residues 154 to 337 of 337 are 98.91 pct identical to residues 1 to 184 of 184 from GenPept 118 : gi|3821827|gb|AAC69663.1| (AF019745) UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase WaaJ [Escherichia coli]. (337 aa)
waaIPutative LPS biosynthesis enzyme; Residues 1 to 335 of 335 are 99.70 pct identical to residues 1 to 335 of 335 from GenPept 118 : gi|3821829|gb|AAC69665.1| (AF019745) UDP-galactose:(glucosyl) LPS alpha1,3-galactosyltransferase WaaI [Escherichia coli]. (335 aa)
dinDDNA-damage-inducible protein; Residues 1 to 278 of 278 are 84.53 pct identical to residues 1 to 278 of 278 from Escherichia coli K-12 Strain MG1655: B3645. (278 aa)
gyrBDNA gyrase subunit B, type II topoisomerase, ATPase activity; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultane [...] (804 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
pinHDNA invertase from prophage CP-933H; Residues 13 to 196 of 196 are 96.73 pct identical to residues 1 to 184 of 184 from GenPept 118 : gi|1787404|gb|AAC74242.1| (AE000214) inversion of adjacent DNA; at locus of e14 element [Escherichia coli]. (196 aa)
adkAdenylate kinase activity; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
bioCBiotin biosynthesis; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (251 aa)
icdAIsocitrate dehydrogenase, specific for NADP+; Residues 1 to 416 of 416 are 99.27 pct identical to residues 1 to 416 of 416 from Escherichia coli K-12 Strain MG1655: B1136. (416 aa)
ompC-2Putative outer membrane porin protein; Residues 6 to 366 of 366 are 66.66 pct identical to residues 8 to 365 of 365 from GenPept 118 : gi|215369|gb|AAA32301.1| (J02580) outer membrane porin protein [Bacteriophage PA-2]; Belongs to the Gram-negative porin family. (366 aa)
ydgDOrf, hypothetical protein; Residues 1 to 273 of 273 are 99.26 pct identical to residues 1 to 273 of 273 from Escherichia coli K-12 Strain MG1655: B1598; Belongs to the peptidase S1B family. (273 aa)
fumCFumarase C= fumarate hydratase Class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
gatDGalactitol-1-phosphate dehydrogenase; Converts galactitol 1-phosphate to tagatose 6-phosphate. (346 aa)
ompCOuter membrane protein 1b (Ib;c); Forms pores that allow passive diffusion of small molecules across the outer membrane. (367 aa)
pdxBErythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (378 aa)
recADNA strand exchange and renaturation, DNA-dependent ATPase, DNA- and ATP-dependent coprotease; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (353 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
Server load: low (14%) [HD]