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ilvI ilvI ilvH ilvH mhpF mhpF sdhC sdhC sdhD sdhD sdhA sdhA sdhB sdhB Z1045 Z1045 pflB pflB adhE adhE yneI yneI gadB gadB ydbK ydbK goaG goaG ydiF ydiF yeaU yeaU fadJ fadJ gabD gabD gabT gabT yqeF yqeF tdcE tdcE gadA gadA ilvN ilvN ilvB ilvB ilvG ilvG ilvM ilvM fadB fadB yihU yihU pflD pflD frdD frdD frdC frdC frdB frdB frdA frdA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene neighborhood
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ilvIAcetolactate synthase III, valine sensitive, large subunit; Residues 1 to 602 of 602 are 99.33 pct identical to residues 3 to 604 of 604 from Escherichia coli K-12 Strain MG1655: B0077. (602 aa)
ilvHAcetolactate synthase III, valine sensitive, small subunit; Residues 1 to 163 of 163 are 98.77 pct identical to residues 1 to 163 of 163 from Escherichia coli K-12 Strain MG1655: B0078. (163 aa)
mhpFAcetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (316 aa)
sdhCSuccinate dehydrogenase, cytochrome b556; Membrane-anchoring subunit of succinate dehydrogenase (SDH). Belongs to the cytochrome b560 family. (129 aa)
sdhDSuccinate dehydrogenase, hydrophobic subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
sdhBSuccinate dehydrogenase, iron sulfur protein; Residues 1 to 238 of 238 are 99.57 pct identical to residues 1 to 238 of 238 from Escherichia coli K-12 Strain MG1655: B0724; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
Z1045Putative pyruvate formate-lyase 2; Residues 1 to 599 of 599 are 98.66 pct identical to residues 212 to 810 of 810 from Escherichia coli K-12 Strain MG1655: B0823. (599 aa)
pflBFormate acetyltransferase 1; Residues 1 to 760 of 760 are 99.47 pct identical to residues 1 to 760 of 760 from Escherichia coli K-12 Strain MG1655: B0903. (760 aa)
adhECoA-linked acetaldehyde dehydrogenase and iron-dependent alcohol dehydrogenase; This enzyme has three activities: ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction (By similarity); In the N-terminal section; belongs to the aldehyde dehydrogenase family. (891 aa)
yneIPutative aldehyde dehydrogenase; Residues 1 to 470 of 470 are 99.36 pct identical to residues 1 to 470 of 470 from Escherichia coli K-12 Strain MG1655: B1525. (470 aa)
gadBGlutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). (466 aa)
ydbKPutative oxidoreductase, Fe-S subunit; Residues 1 to 1174 of 1174 are 99.57 pct identical to residues 1 to 1174 of 1174 from Escherichia coli K-12 Strain MG1655: B1378. (1174 aa)
goaG4-aminobutyrate aminotransferase; Residues 1 to 421 of 421 are 98.57 pct identical to residues 1 to 421 of 421 from Escherichia coli K-12 Strain MG1655: B1302; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
ydiFPutative enzyme; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Exhibits high activity with acetoacetyl-CoA, propionyl-CoA, crotonoyl-CoA or butyryl- CoA as donors, with acetate as an acceptor. When acetyl-CoA is used as the donor, propionate, acetoacetate, butyrate, isobutyrate, and 4- hydroxybutyrate can be utilized as acceptors but not isovalerate. May play a role in short-chain fatty acid metabolism in E.coli. (531 aa)
yeaUPutative tartrate dehydrogenase; Residues 1 to 361 of 361 are 99.72 pct identical to residues 1 to 361 of 361 from Escherichia coli K-12 Strain MG1655: B1800. (361 aa)
fadJPutative enzyme; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (714 aa)
gabDSuccinate-semialdehyde dehydrogenase, NADP-dependent activity; Residues 1 to 482 of 482 are 98.96 pct identical to residues 1 to 482 of 482 from Escherichia coli K-12 Strain MG1655: B2661; Belongs to the aldehyde dehydrogenase family. (482 aa)
gabT4-aminobutyrate aminotransferase activity; Residues 1 to 426 of 426 are 98.59 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 Strain MG1655: B2662; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa)
yqeFPutative acyltransferase; Residues 1 to 394 of 394 are 99.49 pct identical to residues 1 to 394 of 394 from Escherichia coli K-12 Strain MG1655: B2844; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
tdcEProbable formate acetyltransferase 3; Residues 1 to 741 of 764 are 99.86 pct identical to residues 1 to 741 of 746 from Escherichia coli K-12 Strain MG1655: B3114. (764 aa)
gadAGlutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). (466 aa)
ilvNAcetolactate synthase I, valine sensitive, small subunit; Residues 1 to 96 of 96 are 100.00 pct identical to residues 1 to 96 of 96 from Escherichia coli K-12 Strain MG1655: B3670; Belongs to the acetolactate synthase small subunit family. (96 aa)
ilvBAcetolactate synthase I,valine-sensitive, large subunit; Residues 1 to 562 of 562 are 98.57 pct identical to residues 1 to 562 of 562 from Escherichia coli K-12 Strain MG1655: B3671. (562 aa)
ilvGAcetohydroxy acid synthase II; Residues 1 to 326 of 548 are 99.38 pct identical to residues 1 to 326 of 327 from Escherichia coli K-12 Strain MG1655: B3767. (548 aa)
ilvMAcetolactate synthase II, valine insensitive, small subunit; Residues 1 to 87 of 87 are 100.00 pct identical to residues 1 to 87 of 87 from Escherichia coli K-12 Strain MG1655: B3769. (87 aa)
fadB4-enzyme protein: 3-hydroxyacyl-CoA dehydrogenase; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (729 aa)
yihUPutative dehydrogenase; Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1- sulfonate (DHPS); Belongs to the HIBADH-related family. 3-sulfolactaldehyde reductase subfamily. (298 aa)
pflDFormate acetyltransferase 2; Residues 1 to 765 of 765 are 98.82 pct identical to residues 1 to 765 of 765 from Escherichia coli K-12 Strain MG1655: B3951. (765 aa)
frdDFumarate reductase, anaerobic, membrane anchor polypeptide; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (119 aa)
frdCFumarate reductase, anaerobic, membrane anchor polypeptide; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (131 aa)
frdBFumarate reductase, anaerobic, iron-sulfur protein subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (244 aa)
frdAFumarate reductase, anaerobic, flavoprotein subunit; Residues 1 to 602 of 602 are 99.83 pct identical to residues 1 to 602 of 602 from Escherichia coli K-12 Strain MG1655: B4154. (602 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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