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dksA | dnaK suppressor protein; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. (151 aa) | ||||
yaiC | Orf, hypothetical protein; Residues 1 to 371 of 371 are 99.73 pct identical to residues 1 to 371 of 371 from Escherichia coli K-12 Strain MG1655: B0385. (371 aa) | ||||
ag43 | Putative adhesin; Residues 47 to 1005 of 1005 are 68.44 pct identical to residues 43 to 1091 of 1091 from GenPept 118 : gi|1736670|dbj|BAA15825.1| (D90838) Adhesin AIDA-I precursor. [Escherichia coli]. (1005 aa) | ||||
yccZ | Putative function in exopolysaccharide production; May be involved in polysaccharide transport; Belongs to the BexD/CtrA/VexA family. (379 aa) | ||||
ycdP | Orf, hypothetical protein; Required for the synthesis of poly-beta-1,6-N-acetyl-D- glucosamine (PGA), a biofilm adhesin polysaccharide. May assist the glycosyltransferase PgaC in the polymerization of PGA (By similarity). (137 aa) | ||||
ycdQ | Orf, hypothetical protein; Probable N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N-acetylglucosamine to produce the linear homopolymer poly-beta-1,6-N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide; Belongs to the glycosyltransferase 2 family. (441 aa) | ||||
ycdR | Orf, hypothetical protein; Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D- glucosamine (PGA), a biofilm adhesin polysaccharide. N-deacetylation promotes PGA export through the PgaA porin (By similarity). (672 aa) | ||||
ycdS | Putative outer membrane protein; Exports the biofilm adhesin polysaccharide poly-beta-1,6-N- acetyl-D-glucosamine (PGA) across the outer membrane. The PGA transported seems to be partially N-deacetylated since N-deacetylation of PGA by PgaB is needed for PGA export through the PgaA porin (By similarity). (807 aa) | ||||
csgD | Putative 2-component transcriptional regulator for 2nd curli operon; Residues 1 to 216 of 216 are 99.07 pct identical to residues 1 to 216 of 216 from Escherichia coli K-12 Strain MG1655: B1040. (216 aa) | ||||
csgB | Minor curlin subunit precursor, similar ro CsgA; Curlin is the structural subunit of the curli. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers (By similarity); Belongs to the CsgA/CsgB family. (151 aa) | ||||
csgA | Curlin major subunit, coiled surface structures; Curlin is the structural subunit of the curli. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin; Belongs to the CsgA/CsgB family. (152 aa) | ||||
csgC | Putative curli production protein; Residues 1 to 110 of 110 are 98.18 pct identical to residues 1 to 110 of 110 from Escherichia coli K-12 Strain MG1655: B1043. (110 aa) | ||||
flgM | anti-FliA (anti-sigma) factor; Residues 1 to 97 of 97 are 98.96 pct identical to residues 1 to 97 of 97 from Escherichia coli K-12 Strain MG1655: B1071. (97 aa) | ||||
ycgR | Hypothetical protein; Residues 1 to 198 of 198 are 97.47 pct identical to residues 1 to 198 of 244 from Escherichia coli K-12 Strain MG1655: B1194. (198 aa) | ||||
ydeW | Putative transcriptional regulator, sorC family; Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes (By similarity). (317 aa) | ||||
dgcM | Orf, hypothetical protein; Part of a signaling cascade that regulates curli biosynthesis. The cascade is composed of two cyclic-di-GMP (c-di-GMP) control modules, in which c-di-GMP controlled by the DgcE/PdeH pair (module I) regulates the activity of the DgcM/PdeR pair (module II), which in turn regulates activity of the transcription factor MlrA and expression of the master biofilm regulator csgD. (430 aa) | ||||
yciR | Orf, hypothetical protein; Residues 1 to 661 of 661 are 98.94 pct identical to residues 1 to 661 of 661 from Escherichia coli K-12 Strain MG1655: B1285. (661 aa) | ||||
yoaD | Orf, hypothetical protein; Residues 1 to 542 of 542 are 99.07 pct identical to residues 1 to 542 of 542 from Escherichia coli K-12 Strain MG1655: B1815. (542 aa) | ||||
flhC | Regulator of flagellar biosynthesis acting on class 2 operons; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. (192 aa) | ||||
flhD | Regulator of flagellar biosynthesis, acting on class 2 operons; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (119 aa) | ||||
uvrY | Putative 2-component transcriptional regulator; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the effects of CsrA on csrB RNA by BarA-dependent and BarA-independent mechanisms (By similarity). (218 aa) | ||||
sdiA | Transcriptional regulator of ftsQAZ gene cluster; Residues 1 to 240 of 240 are 99.16 pct identical to residues 1 to 240 of 240 from Escherichia coli K-12 Strain MG1655: B1916. (240 aa) | ||||
fliZ | Orf, hypothetical protein; Residues 1 to 195 of 195 are 98.97 pct identical to residues 1 to 195 of 195 from Escherichia coli K-12 Strain MG1655: B1921. (195 aa) | ||||
fliA | Flagellar biosynthesis; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (239 aa) | ||||
rcsA | Positive regulator for ctr capsule biosynthesis, positive transcription factor; Component of the Rcs signaling system, which controls transcription of numerous genes. Binds, with RcsB, to the RcsAB box to regulate expression of genes. (207 aa) | ||||
dgcQ | Orf, hypothetical protein; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Involved in the regulation of cellulose production (By similarity). (564 aa) | ||||
wza | Putative polysaccharide export protein; Probably involved in the export of the extracellular polysaccharide colanic acid from the cell to medium. (379 aa) | ||||
Z3236 | Partial putative sensor kinase; Residues 1 to 935 of 935 are 98.93 pct identical to residues 171 to 1105 of 1105 from Escherichia coli K-12 Strain MG1655: B2067. (935 aa) | ||||
yehV | Putative transcriptional regulator; Residues 1 to 215 of 215 are 99.06 pct identical to residues 29 to 243 of 243 from Escherichia coli K-12 Strain MG1655: B2127. (215 aa) | ||||
yojN | Putative 2-component sensor protein; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (890 aa) | ||||
rcsB | Positive response regulator for colanic capsule biosynthesis, (sensor, RcsC); Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. (216 aa) | ||||
rcsC | Sensor for ctr capsule biosynthesis, probable histidine kinase acting on RcsB; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (933 aa) | ||||
crr | PTS system, glucose-specific IIA component; Residues 1 to 169 of 169 are 99.40 pct identical to residues 1 to 169 of 169 from Escherichia coli K-12 Strain MG1655: B2417. (169 aa) | ||||
gcvR | Transcriptional regulation of gcv operon; Residues 1 to 212 of 212 are 100.00 pct identical to residues 1 to 212 of 212 from Escherichia coli K-12 Strain MG1655: B2479. (212 aa) | ||||
ygaG | Orf, hypothetical protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa) | ||||
csrA | Carbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (61 aa) | ||||
rpoS | RNA polymerase, sigma S (sigma38) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa) | ||||
barA | Sensor-regulator, activates OmpR by phophorylation; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). (918 aa) | ||||
gcvA | Positive regulator of gcv operon; Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter (By similarity); Belongs to the LysR transcriptional regulatory family. (305 aa) | ||||
arcB | Aerobic respiration sensor-response protein; Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His-717 and Asp-576 (By similarity). (778 aa) | ||||
crp | Cyclic AMP receptor protein; A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity). (210 aa) | ||||
envZ | Protein histidine kinase/phosphatase sensor for OmpR, modulates expression of ompF and ompC; Residues 1 to 450 of 450 are 99.77 pct identical to residues 1 to 450 of 450 from Escherichia coli K-12 Strain MG1655: B3404. (450 aa) | ||||
ompR | DNA-binding dual transcriptional regulator OmpR; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes. Plays a central role in both acid and osmotic stress responses. Binds to the promoter of both ompC and ompF; at low osmolarity it activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription. (239 aa) | ||||
malP | Maltodextrin phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (797 aa) | ||||
glgP | Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (815 aa) | ||||
glgA | Glycogen synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (477 aa) | ||||
glgC | Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. (431 aa) | ||||
yhjH | Orf, hypothetical protein; Residues 1 to 255 of 255 are 99.60 pct identical to residues 2 to 256 of 256 from Escherichia coli K-12 Strain MG1655: B3525. (255 aa) | ||||
yhjOP | Putative cellulose synthase; Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose, which is produced as an extracellular component for mechanical and chemical protection at the onset of the stationary phase, when the cells exhibit multicellular behavior (rdar morphotype). Coexpression of cellulose and thin aggregative fimbriae leads to a hydrophobic network with tightly packed cells embedded in a highly inert matrix (By similarity). (888 aa) | ||||
cyaA | Adenylate cyclase; Residues 1 to 848 of 848 are 99.88 pct identical to residues 1 to 848 of 848 from Escherichia coli K-12 Strain MG1655: B3806; Belongs to the adenylyl cyclase class-1 family. (848 aa) | ||||
oxyR | Activator, hydrogen peroxide-inducible genes; Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto- aggregation a [...] (305 aa) | ||||
arcA | Negative response regulator of genes in aerobic pathways, (sensors, ArcB and CpxA); Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expression of genes of aerobic function. Activates the transcription of the plfB operon by binding to its promoter (By similarity). (238 aa) |