STRINGSTRING
yacA yacA secA secA impL impL tssH tssH impK impK tssJ tssJ hcp-2 hcp-2 vgrE-2 vgrE-2 yajC yajC secD secD secF secF tssI tssI ybeC ybeC vgrE vgrE ffh ffh epaO epaO eivA eivA tolC tolC secG secG prlA prlA ftsY ftsY secB secB escF escF sepQ sepQ escN escN escV escV escJ escJ escC escC escU escU escT escT escS escS escR escR yidC yidC tatA tatA tatB tatB tatC tatC secE secE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yacAOrf, hypothetical protein; Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation. Belongs to the SecM family. (195 aa)
secAPreprotein translocase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (901 aa)
impLPutative macrophage toxin; Residues 105 to 1141 of 1144 are 20.61 pct identical to residues 25 to 970 of 973 from GenPept 118 : gi|2897626|emb|CAA75338.1| (Y15044) IcmF protein [Legionella pneumophila]. (1144 aa)
tssHPutative protease; Residues 132 to 884 of 923 are 40.05 pct identical to residues 110 to 838 of 911 from GenPept 118 : gi|530207|gb|AAA66338.1| (L35272) heat shock protein [Glycine max]; Belongs to the ClpA/ClpB family. (923 aa)
impKHypothetical protein; No significant matches. (253 aa)
tssJHypothetical protein; No significant matches. (174 aa)
hcp-2Hypothetical protein; Residues 1 to 172 of 172 are 100.00 pct identical to residues 1 to 172 of 172 from GenPept 118 : gi|2920641|gb|AAC32476.1| (AF044503) hcp [Escherichia coli]. (172 aa)
vgrE-2Hypothetical protein; Residues 1 to 713 of 713 are 98.73 pct identical to residues 1 to 713 of 713 from GenPept 118 : gi|2920640|gb|AAC32475.1| (AF044503) VgrG protein [Escherichia coli]. (713 aa)
yajCOrf, hypothetical protein; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (110 aa)
secDProtein secretion; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (615 aa)
secFProtein secretion, membrane protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (323 aa)
tssIHypothetical protein; Residues 1 to 529 of 633 are 93.00 pct identical to residues 1 to 529 of 713 from GenPept 118 : gi|2920640|gb|AAC32475.1| (AF044503) VgrG protein [Escherichia coli]. (633 aa)
ybeCOrf, hypothetical protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA; Belongs to the TatA/E family. TatE subfamily. (67 aa)
vgrEUnknown protein associated with Rhs element; Residues 13 to 714 of 714 are 98.43 pct identical to residues 1 to 702 of 702 from GenPept 118 : gi|2920625|gb|AAC32465.1| (AF044499) vgrE protein [Escherichia coli]. (714 aa)
ffhGTP-binding export factor binds to signal sequence, GTP and RNA; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex [...] (453 aa)
epaOtypeIII secretion apparatus protein; Residues 35 to 326 of 328 are 32.44 pct identical to residues 23 to 301 of 303 from GenPept 118 : gi|973281|gb|AAC43947.1| (U29351) SpaO [Salmonella enterica]. (328 aa)
eivAType III secretion apparatus protein; Residues 1 to 686 of 686 are 64.00 pct identical to residues 1 to 685 of 685 from GenPept 118 : gi|461369|gb|AAA16867.1| (M90846) GTG start codon [Salmonella typhimurium]. (686 aa)
tolCOuter membrane channel; Residues 1 to 495 of 495 are 99.79 pct identical to residues 1 to 495 of 495 from Escherichia coli K-12 Strain MG1655: B3035. (495 aa)
secGProtein export - membrane protein; Involved in protein export. Participates in an early event of protein translocation (By similarity). (110 aa)
prlAPutative ATPase subunit of translocase; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (443 aa)
ftsYCell division membrane protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (498 aa)
secBProtein export; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (155 aa)
escFescF; Residues 1 to 73 of 73 are 100.00 pct identical to residues 1 to 73 of 73 from GenPept 118 : gi|3941402|gb|AAC82362.1| (AF054421) EscF [Escherichia coli]. (73 aa)
sepQsepQ; Residues 1 to 305 of 305 are 100.00 pct identical to residues 1 to 305 of 305 from GenPept 118 : gi|3414899|gb|AAC31510.1| (AF071034) L0031 [Escherichia coli]. (305 aa)
escNescN; Residues 1 to 446 of 446 are 100.00 pct identical to residues 1 to 446 of 446 from GenPept 118 : gi|3414902|gb|AAC31513.1| (AF071034) L0034 [Escherichia coli]. (446 aa)
escVescV; Residues 1 to 675 of 675 are 100.00 pct identical to residues 1 to 675 of 675 from GenPept 118 : gi|3414903|gb|AAC31514.1| (AF071034) L0035 [Escherichia coli]. (675 aa)
escJescJ; Residues 1 to 190 of 190 are 100.00 pct identical to residues 1 to 190 of 190 from GenPept 118 : gi|2865286|gb|AAC38379.1| (AF022236) EscJ [Escherichia coli]. (190 aa)
escCescC; Residues 1 to 512 of 512 are 100.00 pct identical to residues 1 to 512 of 512 from GenPept 118 : gi|3414909|gb|AAC31520.1| (AF071034) L0041 [Escherichia coli]. (512 aa)
escUescU; Residues 1 to 345 of 345 are 100.00 pct identical to residues 1 to 345 of 345 from GenPept 118 : gi|3414914|gb|AAC31525.1| (AF071034) L0046 [Escherichia coli]. (345 aa)
escTescT; Residues 1 to 258 of 258 are 100.00 pct identical to residues 1 to 258 of 258 from GenPept 118 : gi|3414915|gb|AAC31526.1| (AF071034) L0047 [Escherichia coli]. (258 aa)
escSescS; Residues 1 to 89 of 89 are 100.00 pct identical to residues 1 to 89 of 89 from GenPept 118 : gi|2865277|gb|AAC38370.1| (AF022236) EscS [Escherichia coli]. (89 aa)
escRescR; Residues 1 to 217 of 217 are 100.00 pct identical to residues 1 to 217 of 217 from GenPept 118 : gi|3414917|gb|AAC31528.1| (AF071034) L0049 [Escherichia coli]. (217 aa)
yidC60 KD inner-membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (548 aa)
tatATwin arginine translocation protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (103 aa)
tatBHypothetical protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (145 aa)
tatCPutative integral membrane protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (258 aa)
secEPreprotein translocase; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (127 aa)
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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