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AOH82747.1 AOH82747.1 AOH82751.1 AOH82751.1 AOH82782.1 AOH82782.1 argB argB AOH82946.1 AOH82946.1 hisG hisG hisD hisD argH argH lysA lysA AOH83065.1 AOH83065.1 AOH83083.1 AOH83083.1 AOH83181.1 AOH83181.1 AOH83182.1 AOH83182.1 AOH83183.1 AOH83183.1 AOH83184.1 AOH83184.1 AOH86484.1 AOH86484.1 aroC aroC aroE aroE argG argG dapF dapF AOH83517.1 AOH83517.1 hisC hisC AOH86573.1 AOH86573.1 AOH83704.1 AOH83704.1 AOH83705.1 AOH83705.1 AOH83853.1 AOH83853.1 aroQ aroQ AOH84002.1 AOH84002.1 argD argD asd asd AOH84183.1 AOH84183.1 AOH84225.1 AOH84225.1 dapB dapB AOH84298.1 AOH84298.1 AOH86694.1 AOH86694.1 AOH84428.1 AOH84428.1 AOH84429.1 AOH84429.1 hisE hisE AOH84431.1 AOH84431.1 hisF hisF AOH84433.1 AOH84433.1 hisA hisA hisH hisH hisB hisB AOH84482.1 AOH84482.1 AOH84483.1 AOH84483.1 AOH84756.1 AOH84756.1 AOH84796.1 AOH84796.1 trpA trpA trpB trpB trpF trpF aroB aroB aroK aroK AOH84837.1 AOH84837.1 dapA dapA argC argC hisI hisI AOH84978.1 AOH84978.1 aroA aroA AOH85232.1 AOH85232.1 asd-2 asd-2 dadA dadA AOH85495.1 AOH85495.1 AOH85905.1 AOH85905.1 dapF-2 dapF-2 AOH85958.1 AOH85958.1 AOH86088.1 AOH86088.1 AOH86988.1 AOH86988.1 trpD trpD trpC trpC argJ argJ AOH86220.1 AOH86220.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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AOH82747.1Prephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
AOH82751.1ATP phosphoribosyltransferase regulatory subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
AOH82782.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (420 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa)
AOH82946.1Phenylalanine-4-hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (220 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (427 aa)
argHArgininosuccinate lyase; Catalyzes the formation of arginine from (N-L-arginino)succinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (442 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa)
AOH83065.12-keto-4-pentenoate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
AOH83083.1Pterin-4-alpha-carbinolamine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (96 aa)
AOH83181.1Phenylalanine-4-hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
AOH83182.1Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
AOH83183.1Fumarylacetoacetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
AOH83184.1Maleylacetoacetate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
AOH86484.1Pterin-4-alpha-carbinolamine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (101 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (359 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (269 aa)
argGArgininosuccinate synthase; Catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (405 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (317 aa)
AOH83517.1Cyclohexadienyl dehydrogenase; Dual function enzyme catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate and the formation of tyrosine from arogenate; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
hisCHistidinol-phosphate aminotransferase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa)
AOH86573.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
AOH83704.1Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
AOH83705.1Aminobenzoate synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (591 aa)
AOH83853.1Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (94 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (144 aa)
AOH84002.1Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (306 aa)
argDAcetylornithine aminotransferase; Catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (397 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (349 aa)
AOH84183.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
AOH84225.1Shikimate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (245 aa)
AOH84298.1Fumarylacetoacetate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
AOH86694.1Dihydrodipicolinate synthase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DapA family. (303 aa)
AOH84428.1Amino acid permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (522 aa)
AOH84429.1Histidine triad nucleotide-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (126 aa)
hisEphosphoribosyl-ATP pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
AOH84431.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (63 aa)
hisFImidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (255 aa)
AOH84433.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (80 aa)
hisA1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase; Catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-hosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (201 aa)
hisBImidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
AOH84482.1An oxygenase that acts to open the ring of homogentisate formingmaleylacetoacetate as part of the catabolism of L-tyrosine and L-phenylalanine; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
AOH84483.14-hydroxyphenylpyruvate dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
AOH84756.1Fumarylacetoacetate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
AOH84796.1Acetylornithine deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (409 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (212 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (366 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (158 aa)
AOH84837.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (309 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (120 aa)
AOH84978.1Fumarylacetoacetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (448 aa)
AOH85232.1Fumarylacetoacetate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
asd-2Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa)
dadAD-amino acid dehydrogenase small subunit; Oxidative deamination of D-amino acids. (416 aa)
AOH85495.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
AOH85905.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (218 aa)
dapF-2Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (266 aa)
AOH85958.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
AOH86088.1Anthranilate synthase; With component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; Derived by automated computational analysis using gene prediction method: Protein Homology. (506 aa)
AOH86988.1Aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (331 aa)
trpCIndole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (261 aa)
argJArginine biosynthesis protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (409 aa)
AOH86220.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (528 aa)
Your Current Organism:
Sphingomonas panacis
NCBI taxonomy Id: 1560345
Other names: JCM 30806, KCTC 42347, S. panacis, Sphingomonas panacis Singh et al. 2017, Sphingomonas sp. DCY99, strain DCY99
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