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AOH82726.1 AOH82726.1 AOH82750.1 AOH82750.1 AOH86400.1 AOH86400.1 AOH82782.1 AOH82782.1 metK metK metK-2 metK-2 AOH82862.1 AOH82862.1 mdh mdh AOH83182.1 AOH83182.1 AOH83187.1 AOH83187.1 AOH83483.1 AOH83483.1 AOH83484.1 AOH83484.1 AOH83510.1 AOH83510.1 AOH83704.1 AOH83704.1 AOH83873.1 AOH83873.1 gshB gshB AOH84126.1 AOH84126.1 sseA sseA mtnA mtnA mtnC mtnC mtnD mtnD mtnB mtnB AOH84141.1 AOH84141.1 asd asd AOH84183.1 AOH84183.1 AOH84550.1 AOH84550.1 mtnP mtnP AOH84761.1 AOH84761.1 AOH84895.1 AOH84895.1 AOH84973.1 AOH84973.1 AOH85075.1 AOH85075.1 AOH85303.1 AOH85303.1 metAA metAA metZ metZ AOH85426.1 AOH85426.1 ahcY ahcY AOH86899.1 AOH86899.1 asd-2 asd-2 AOH86928.1 AOH86928.1 AOH85925.1 AOH85925.1 AOH86078.1 AOH86078.1 AOH86121.1 AOH86121.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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AOH82726.1Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
AOH82750.1Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (380 aa)
AOH86400.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (525 aa)
AOH82782.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (420 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (406 aa)
metK-2S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa)
AOH82862.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (399 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
AOH83182.1Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
AOH83187.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (459 aa)
AOH83483.15-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
AOH83484.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (889 aa)
AOH83510.1Methionine gamma-lyase; Catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
AOH83704.1Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
AOH83873.1Phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
gshBGlutathione synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic GSH synthase family. (318 aa)
AOH84126.1Cystathionine beta-lyase; Catalyzes the formation of L-homocysteine from cystathionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
sseA3-mercaptopyruvate sulfurtransferase; Catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; Derived by automated computational analysis using gene prediction method: Protein Homology. (279 aa)
mtnAMethylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (343 aa)
mtnCEnolase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (215 aa)
mtnDCupin; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (179 aa)
mtnBMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (205 aa)
AOH84141.1Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. (461 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (349 aa)
AOH84183.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
AOH84550.1Cysteine synthase; CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
mtnP5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (289 aa)
AOH84761.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa)
AOH84895.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (306 aa)
AOH84973.1Enterotoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
AOH85075.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
AOH85303.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (196 aa)
metAAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (307 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (402 aa)
AOH85426.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (161 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (472 aa)
AOH86899.1Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
asd-2Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa)
AOH86928.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (487 aa)
AOH85925.15-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
AOH86078.1Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
AOH86121.1Phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
Your Current Organism:
Sphingomonas panacis
NCBI taxonomy Id: 1560345
Other names: JCM 30806, KCTC 42347, S. panacis, Sphingomonas panacis Singh et al. 2017, Sphingomonas sp. DCY99, strain DCY99
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