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AQM60419.1 AQM60419.1 upp upp tdk tdk pyrG pyrG NPD11_142 NPD11_142 nrdB nrdB AQM59919.1 AQM59919.1 pyrR pyrR AQM59158.1 AQM59158.1 AQM60870.1 AQM60870.1 nrdD nrdD carB carB carA carA thyA thyA pyrH pyrH hydA hydA AQM59424.1 AQM59424.1 udp udp dut dut cdd cdd ndk ndk cmk cmk pdp pdp udk udk deoD deoD NPD11_729 NPD11_729 NPD11_730 NPD11_730 pyrE pyrE pyrD pyrD pyrF pyrF pyrC pyrC NPD11_986 NPD11_986 pyrB pyrB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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AQM60419.1Cytidine and deoxycytidylate deaminase zinc-binding region family protein; [F] COG2131 Deoxycytidylate deaminase. (164 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
tdk[F] COG1435 Thymidine kinase. (195 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (539 aa)
NPD11_142[G] COG0524 Sugar kinases, ribokinase family. (316 aa)
nrdBRibonucleotide reductase, small chain family protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (345 aa)
AQM59919.1Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (743 aa)
pyrRPhosphoribosyl transferase domain protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (179 aa)
AQM59158.1[F] COG0125 Thymidylate kinase. (226 aa)
AQM60870.1Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa)
nrdDnrdD: anaerobic ribonucleoside-triphosphate reductase; [F] COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase. (705 aa)
carBCPSaseII_lrg: carbamoyl-phosphate synthase, large subunit; [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. (1071 aa)
carACPSaseIIsmall: carbamoyl-phosphate synthase, small subunit; [EF] COG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (349 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (263 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (236 aa)
hydAD-hydantoinase: dihydropyrimidinase; [F] COG0044 Dihydroorotase and related cyclic amidohydrolases. (460 aa)
AQM59424.1Phosphoribulokinase / Uridine kinase family protein; [F] COG0572 Uridine kinase. (551 aa)
udpUridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (257 aa)
dutdUTP diphosphatase family protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (146 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (132 aa)
ndkNucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (135 aa)
cmkCmk: cytidylate kinase; [F] COG0283 Cytidylate kinase. (218 aa)
pdp[F] COG0213 Thymidine phosphorylase. (434 aa)
udkUdk: uridine kinase; [F] COG0572 Uridine kinase. (205 aa)
deoDdeoD: purine nucleoside phosphorylase; [F] COG0813 Purine-nucleoside phosphorylase. (238 aa)
NPD11_729pyrD_sub1_fam: dihydroorotate dehydrogenase family domain protein; [F] COG0167 Dihydroorotate dehydrogenase. (411 aa)
NPD11_730FAD dependent oxidoreductase family protein; [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. (424 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (225 aa)
pyrDDihydroorotate dehydrogenase family domain protein; Catalyzes the conversion of dihydroorotate to orotate. (298 aa)
pyrFpyrF_sub2: orotidine 5'-phosphate decarboxylase; [F] COG0284 Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (289 aa)
pyrCDihydroorotase, multifunctional complex type domain protein; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (398 aa)
NPD11_986Aspartate carbamoyltransferase regulatory chain, metal binding domain protein; [F] COG1781 Aspartate carbamoyltransferase, regulatory subunit. (141 aa)
pyrBAsp_carb_tr: aspartate carbamoyltransferase; [F] COG0540 Aspartate carbamoyltransferase, catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (307 aa)
Your Current Organism:
Clostridium baratii
NCBI taxonomy Id: 1561
Other names: ATCC 27638, Acuformis perennis, BCRC 14541, C. baratii, CCRC 14541, CCRC:14541, CCUG 24033, CIP 104306, Clostridium barati, Clostridium paraperfringens, Clostridium perenne, DSM 601, Inflabilis barati
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