(13 nodes) ACT domain network (Streptomyces sp. CCMMD2014)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AIV33831.1	Kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (725 aa)
	AIV35436.1	Prephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
	AIV35117.1	Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (425 aa)
	AIV34491.1	Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
	AIV34206.1	Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
	AIV34057.1	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (174 aa)
	AIV34055.1	3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
	glnD	protein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (840 aa)
	AIV37278.1	Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (361 aa)
	AIV37237.1	Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (414 aa)
	AIV36161.1	Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
	purU	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (297 aa)
	AIV37505.1	GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (847 aa)

Your Current Organism:

Streptomyces sp. CCMMD2014

NCBI taxonomy Id: 1561022
Other names: S. sp. CCM_MD2014, Streptomyces sp. CCM_MD2014

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIV33831.1	AIV37505.1	NI25_10250	NI25_31650	Kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.912
AIV34055.1	AIV34057.1	NI25_11640	NI25_11650	3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.856
AIV34055.1	AIV34206.1	NI25_11640	NI25_12470	3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.652
AIV34055.1	AIV34491.1	NI25_11640	NI25_14105	3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.540
AIV34055.1	AIV35117.1	NI25_11640	NI25_17710	3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family.	0.476
AIV34055.1	AIV37237.1	NI25_11640	NI25_30165	3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.711
AIV34055.1	purU	NI25_11640	NI25_22265	3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).	0.476
AIV34057.1	AIV34055.1	NI25_11650	NI25_11640	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.856
AIV34057.1	AIV34206.1	NI25_11650	NI25_12470	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.824
AIV34057.1	AIV34491.1	NI25_11650	NI25_14105	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.979
AIV34057.1	AIV35436.1	NI25_11650	NI25_19565	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Prephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.813
AIV34057.1	AIV36161.1	NI25_11650	NI25_24005	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.828
AIV34206.1	AIV34055.1	NI25_12470	NI25_11640	Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.652
AIV34206.1	AIV34057.1	NI25_12470	NI25_11650	Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.824
AIV34206.1	AIV34491.1	NI25_12470	NI25_14105	Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.456
AIV34206.1	AIV35117.1	NI25_12470	NI25_17710	Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family.	0.913
AIV34206.1	AIV35436.1	NI25_12470	NI25_19565	Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Prephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.456
AIV34206.1	AIV37278.1	NI25_12470	NI25_30415	Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.528
AIV34491.1	AIV34055.1	NI25_14105	NI25_11640	Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.540
AIV34491.1	AIV34057.1	NI25_14105	NI25_11650	Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.979