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ilvA ilvA ldh-3 ldh-3 AJS57431.1 AJS57431.1 sdhA sdhA sdhB sdhB ilvE ilvE AJS57528.1 AJS57528.1 ilvD ilvD AJS57576.1 AJS57576.1 AJS57832.1 AJS57832.1 AJS57912.1 AJS57912.1 AJS57913.1 AJS57913.1 AJS57914.1 AJS57914.1 AJS57964.1 AJS57964.1 AJS57965.1 AJS57965.1 AJS57966.1 AJS57966.1 lipB lipB ilvD-2 ilvD-2 ackA ackA leuC leuC leuD leuD AJS61422.1 AJS61422.1 pdhA pdhA AJS58348.1 AJS58348.1 AJS58349.1 AJS58349.1 AJS58350.1 AJS58350.1 AJS58429.1 AJS58429.1 AJS58547.1 AJS58547.1 AJS58687.1 AJS58687.1 AJS58949.1 AJS58949.1 AJS61501.1 AJS61501.1 AJS59044.1 AJS59044.1 AJS59088.1 AJS59088.1 AJS59089.1 AJS59089.1 AJS59090.1 AJS59090.1 AJS59099.1 AJS59099.1 sucD sucD sucC sucC AJS59414.1 AJS59414.1 AJS59557.1 AJS59557.1 mdh mdh AJS59583.1 AJS59583.1 AJS59584.1 AJS59584.1 AJS59587.1 AJS59587.1 AJS59696.1 AJS59696.1 leuB leuB leuA leuA ilvC ilvC AJS59707.1 AJS59707.1 AJS59708.1 AJS59708.1 AJS59728.1 AJS59728.1 odhA odhA AJS59750.1 AJS59750.1 AJS60017.1 AJS60017.1 lipA lipA AJS60174.1 AJS60174.1 iolA iolA ppc ppc AJS61663.1 AJS61663.1 fumC fumC AJS61669.1 AJS61669.1 AJS60577.1 AJS60577.1 AJS60591.1 AJS60591.1 ldh ldh ldh-2 ldh-2 AJS61721.1 AJS61721.1 AJS61199.1 AJS61199.1 AJS61298.1 AJS61298.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (410 aa)
ldh-3Lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (309 aa)
AJS57431.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (581 aa)
sdhBPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (294 aa)
AJS57528.1Branched-chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
ilvDDihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (561 aa)
AJS57576.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (592 aa)
AJS57832.1acetyl-CoA synthetase; Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa)
AJS57912.1Acetaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (869 aa)
AJS57913.1Formate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (753 aa)
AJS57914.1Pyruvate formate lyase-activating protein; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (246 aa)
AJS57964.1Dihydrolipoamide dehydrogenase; E3 component of the branched-chain alpha-keto acid dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
AJS57965.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
AJS57966.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
lipBOctanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (234 aa)
ilvD-2Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (563 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa)
leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (473 aa)
leuDIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa)
AJS61422.1Fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (600 aa)
pdhAPyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (355 aa)
AJS58348.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
AJS58349.1Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
AJS58350.1Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
AJS58429.1acyl--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (530 aa)
AJS58547.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
AJS58687.1Oxalate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
AJS58949.1Propanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (211 aa)
AJS61501.1Acylphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (89 aa)
AJS59044.1Leucine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (368 aa)
AJS59088.1Quinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
AJS59089.1Pyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (768 aa)
AJS59090.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
AJS59099.1Propanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (190 aa)
sucDsuccinyl-CoA synthetase subsunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (309 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
AJS59414.1Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (539 aa)
AJS59557.1Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (313 aa)
AJS59583.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
AJS59584.1Citrate synthase; Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
AJS59587.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
AJS59696.1Nucleoid-structuring protein H-NS; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (359 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (505 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa)
AJS59707.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (161 aa)
AJS59708.1Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (582 aa)
AJS59728.1Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (439 aa)
odhA2-oxoglutarate dehydrogenase; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (958 aa)
AJS59750.1Lipoate--protein ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
AJS60017.12-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). Belongs to the alpha-IPM synthase/homocitrate synthase family. (509 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (293 aa)
AJS60174.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (470 aa)
iolAMethylmalonate-semialdehyde dehydrogenase; Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively. (483 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (933 aa)
AJS61663.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (459 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
AJS61669.1Ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
AJS60577.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
AJS60591.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (294 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (309 aa)
ldh-2Lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (318 aa)
AJS61721.1Aminotransferase class III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (433 aa)
AJS61199.1Reduces fumarate to succinate in anaerobic bacterial respiration; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (509 aa)
AJS61298.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
Your Current Organism:
Paenibacillus sp. IHBB10380
NCBI taxonomy Id: 1566358
Other names: P. sp. IHBB 10380, Paenibacillus sp. IHBB 10380
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