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AJS57431.1 AJS57431.1 sdhA sdhA sdhB sdhB AJS57964.1 AJS57964.1 pdhA pdhA AJS58348.1 AJS58348.1 AJS58349.1 AJS58349.1 AJS58350.1 AJS58350.1 AJS59089.1 AJS59089.1 AJS59090.1 AJS59090.1 sucD sucD sucC sucC AJS59557.1 AJS59557.1 mdh mdh AJS59583.1 AJS59583.1 AJS59584.1 AJS59584.1 AJS59728.1 AJS59728.1 odhA odhA fumC fumC AJS61199.1 AJS61199.1 AJS61298.1 AJS61298.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AJS57431.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (581 aa)
sdhBPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
AJS57964.1Dihydrolipoamide dehydrogenase; E3 component of the branched-chain alpha-keto acid dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
pdhAPyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (355 aa)
AJS58348.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
AJS58349.1Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
AJS58350.1Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
AJS59089.1Pyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (768 aa)
AJS59090.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
sucDsuccinyl-CoA synthetase subsunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (309 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
AJS59557.1Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (313 aa)
AJS59583.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
AJS59584.1Citrate synthase; Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
AJS59728.1Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (439 aa)
odhA2-oxoglutarate dehydrogenase; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (958 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
AJS61199.1Reduces fumarate to succinate in anaerobic bacterial respiration; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (509 aa)
AJS61298.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
Your Current Organism:
Paenibacillus sp. IHBB10380
NCBI taxonomy Id: 1566358
Other names: P. sp. IHBB 10380, Paenibacillus sp. IHBB 10380
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