STRINGSTRING
ilvA ilvA AJS61323.1 AJS61323.1 AJS57178.1 AJS57178.1 AJS57204.1 AJS57204.1 AJS57431.1 AJS57431.1 sdhA sdhA sdhB sdhB AJS57620.1 AJS57620.1 AJS57821.1 AJS57821.1 AJS57832.1 AJS57832.1 AJS57867.1 AJS57867.1 AJS57939.1 AJS57939.1 AJS57940.1 AJS57940.1 folD folD AJS57964.1 AJS57964.1 AJS58004.1 AJS58004.1 AJS58054.1 AJS58054.1 AJS58081.1 AJS58081.1 ackA ackA pdhA pdhA AJS58348.1 AJS58348.1 AJS58349.1 AJS58349.1 AJS58350.1 AJS58350.1 AJS58429.1 AJS58429.1 AJS58505.1 AJS58505.1 AJS58507.1 AJS58507.1 AJS58508.1 AJS58508.1 glyA glyA AJS58626.1 AJS58626.1 AJS58707.1 AJS58707.1 tal tal AJS58718.1 AJS58718.1 AJS58949.1 AJS58949.1 AJS58974.1 AJS58974.1 AJS59015.1 AJS59015.1 AJS59089.1 AJS59089.1 AJS59090.1 AJS59090.1 AJS59099.1 AJS59099.1 sucD sucD sucC sucC rpiA rpiA AJS61545.1 AJS61545.1 AJS59342.1 AJS59342.1 AJS59377.1 AJS59377.1 pfkA pfkA AJS59486.1 AJS59486.1 AJS61563.1 AJS61563.1 AJS59557.1 AJS59557.1 mdh mdh AJS59583.1 AJS59583.1 AJS59584.1 AJS59584.1 AJS59587.1 AJS59587.1 accA accA accD accD serC serC AJS59728.1 AJS59728.1 odhA odhA pgi pgi AJS59811.1 AJS59811.1 zwf zwf fabV fabV AJS60174.1 AJS60174.1 iolA iolA ppc ppc AJS60299.1 AJS60299.1 glyA-2 glyA-2 AJS60414.1 AJS60414.1 fhs fhs fumC fumC gpmA gpmA AJS60511.1 AJS60511.1 AJS60577.1 AJS60577.1 AJS60636.1 AJS60636.1 prs prs AJS60756.1 AJS60756.1 AJS60795.1 AJS60795.1 prs-2 prs-2 AJS60824.1 AJS60824.1 AJS60838.1 AJS60838.1 pgk pgk tpiA tpiA gpmI gpmI eno eno AJS60899.1 AJS60899.1 AJS61017.1 AJS61017.1 AJS61134.1 AJS61134.1 AJS61199.1 AJS61199.1 AJS61298.1 AJS61298.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (410 aa)
AJS61323.1Gluconokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FGGY kinase family. (509 aa)
AJS57178.16-phosphogluconate dehydrogenase; Similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
AJS57204.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (411 aa)
AJS57431.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (581 aa)
sdhBPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
AJS57620.13-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (798 aa)
AJS57821.16-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (470 aa)
AJS57832.1acetyl-CoA synthetase; Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa)
AJS57867.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (220 aa)
AJS57939.1acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (163 aa)
AJS57940.1acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
folD5,10-methylene-tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa)
AJS57964.1Dihydrolipoamide dehydrogenase; E3 component of the branched-chain alpha-keto acid dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
AJS58004.1D-3-phosphoglycerate dehydrogenase; Catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (530 aa)
AJS58054.1Phosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
AJS58081.13-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa)
pdhAPyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (355 aa)
AJS58348.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
AJS58349.1Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
AJS58350.1Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
AJS58429.1acyl--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (530 aa)
AJS58505.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (520 aa)
AJS58507.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (298 aa)
AJS58508.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (232 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (414 aa)
AJS58626.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa)
AJS58707.1Transaldolase; Similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (222 aa)
AJS58718.16-phosphogluconate dehydrogenase; Similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
AJS58949.1Propanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (211 aa)
AJS58974.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
AJS59015.13-carboxymuconate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
AJS59089.1Pyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (768 aa)
AJS59090.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
AJS59099.1Propanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (190 aa)
sucDsuccinyl-CoA synthetase subsunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (309 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (223 aa)
AJS61545.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (305 aa)
AJS59342.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (222 aa)
AJS59377.1Gluconokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FGGY kinase family. (521 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (322 aa)
AJS59486.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
AJS61563.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
AJS59557.1Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (313 aa)
AJS59583.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
AJS59584.1Citrate synthase; Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
AJS59587.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
accAacetyl-CoA carboxyl transferase; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (334 aa)
accDacetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (296 aa)
serCMFS transporter; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (362 aa)
AJS59728.1Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (439 aa)
odhA2-oxoglutarate dehydrogenase; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (958 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (451 aa)
AJS59811.1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (680 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (515 aa)
fabVtrans-2-enoyl-CoA reductase; Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA); Belongs to the TER reductase family. (397 aa)
AJS60174.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (470 aa)
iolAMethylmalonate-semialdehyde dehydrogenase; Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively. (483 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (933 aa)
AJS60299.1Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa)
AJS60414.1Ribose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (151 aa)
fhsFormate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. (543 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (249 aa)
AJS60511.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (304 aa)
AJS60577.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
AJS60636.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (412 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa)
AJS60756.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (312 aa)
AJS60795.1Fructose-bisphosphate aldolase; Catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; induced by anaerobic conditions in Bacillus subtilis; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
prs-2Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)
AJS60824.1Glucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
AJS60838.1Glyceraldehyde-3-phosphate dehydrogenase; NAD-dependent; catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; active during glycolysis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (393 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa)
gpmIPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
AJS60899.12-dehydro-3-deoxygluconokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
AJS61017.16-phosphogluconolactonase; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
AJS61134.1Catalase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the catalase family. (485 aa)
AJS61199.1Reduces fumarate to succinate in anaerobic bacterial respiration; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (509 aa)
AJS61298.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
Your Current Organism:
Paenibacillus sp. IHBB10380
NCBI taxonomy Id: 1566358
Other names: P. sp. IHBB 10380, Paenibacillus sp. IHBB 10380
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