(46 nodes) Valine, leucine and isoleucine degradation network (Jaminaea rosea)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A316V3Z2	NAD(P)-binding protein. (280 aa)
	A0A316UGY4	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (572 aa)
	A0A316UHD6	Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (413 aa)
	A0A316UHI0	Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (425 aa)
	A0A316UIL7	Putative short chain 3-hydroxyacyl-CoA dehydrogenase mitochondrial. (329 aa)
	A0A316UIQ4	Aldolase. (925 aa)
	A0A316UIS9	Putative indole-3-acetaldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (497 aa)
	A0A316UJP5	FAD/NAD(P)-binding domain-containing protein. (591 aa)
	A0A316UKV3	SET domain-containing protein. (615 aa)
	A0A316ULI9	Uncharacterized protein. (643 aa)
	A0A316UM07	Acetoacetate-CoA ligase. (786 aa)
	A0A316UM30	Dihydrolipoyl dehydrogenase. (507 aa)
	A0A316UME0	SET domain-containing protein. (387 aa)
	A0A316UMG3	Acyl-CoA dehydrogenase NM domain-like protein. (454 aa)
	A0A316UMW2	Uncharacterized protein. (589 aa)
	A0A316UPA0	ClpP/crotonase; Belongs to the enoyl-CoA hydratase/isomerase family. (309 aa)
	A0A316UQ35	Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
	A0A316UQ74	Putative 3-hydroxyisobutyrate dehydrogenase mitochondrial. (379 aa)
	A0A316UQW6	Putative aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (509 aa)
	A0A316UR38	Putative enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (289 aa)
	A0A316URW3	Uncharacterized protein. (875 aa)
	A0A316URY7	Amine oxidase. (583 aa)
	A0A316USW7	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (470 aa)
	A0A316UTA0	Thiamine diphosphate-binding protein. (338 aa)
	A0A316UTB7	Uncharacterized protein. (339 aa)
	A0A316UTJ5	3-oxoacid CoA-transferase. (526 aa)
	A0A316UUD5	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (386 aa)
	A0A316UUN2	ARM repeat-containing protein. (1001 aa)
	A0A316UUV6	Uncharacterized protein. (947 aa)
	A0A316UVL3	Uncharacterized protein. (551 aa)
	A0A316UWF4	Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
	A0A316UWQ7	Acyl-CoA dehydrogenase NM domain-like protein. (462 aa)
	A0A316UXH1	4-aminobutyrate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (492 aa)
	A0A316UXK1	Uncharacterized protein. (309 aa)
	A0A316UXP7	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (512 aa)
	A0A316UXZ7	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (411 aa)
	A0A316UYA2	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (464 aa)
	A0A316UYG9	Homoserine acetyltransferase. (550 aa)
	A0A316UYZ7	APH-domain-containing protein. (420 aa)
	A0A316UZK2	Methylmalonate-semialdehyde dehydrogenase. (548 aa)
	A0A316UZW6	Acyl-CoA dehydrogenase NM domain-like protein. (435 aa)
	A0A316V087	SET domain-containing protein. (543 aa)
	A0A316V0F1	Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
	A0A316V198	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (531 aa)
	A0A316V215	Uncharacterized protein. (218 aa)
	A0A316V2R9	Acyl-CoA dehydrogenase NM domain-like protein. (528 aa)

Your Current Organism:

Jaminaea rosea

NCBI taxonomy Id: 1569628
Other names: CBS 14051, J. rosea, Jaminaea sp. MCA 5214, Jaminaea sp. MCA5214, MCA 5214

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A316UGY4	A0A316UHD6	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.825
A0A316UGY4	A0A316UHI0	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.825
A0A316UGY4	A0A316UIL7	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Putative short chain 3-hydroxyacyl-CoA dehydrogenase mitochondrial.	0.859
A0A316UGY4	A0A316UIQ4	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Aldolase.	0.537
A0A316UGY4	A0A316UM07	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Acetoacetate-CoA ligase.	0.549
A0A316UGY4	A0A316UMG3	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Acyl-CoA dehydrogenase NM domain-like protein.	0.795
A0A316UGY4	A0A316UPA0	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	ClpP/crotonase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.656
A0A316UGY4	A0A316UQ35	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.832
A0A316UGY4	A0A316UQ74	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Putative 3-hydroxyisobutyrate dehydrogenase mitochondrial.	0.889
A0A316UGY4	A0A316UR38	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Putative enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family.	0.884
A0A316UGY4	A0A316URW3	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein.	0.825
A0A316UGY4	A0A316USW7	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.616
A0A316UGY4	A0A316UTJ5	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	3-oxoacid CoA-transferase.	0.709
A0A316UGY4	A0A316UUV6	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein.	0.537
A0A316UGY4	A0A316UWF4	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.825
A0A316UGY4	A0A316UWQ7	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Acyl-CoA dehydrogenase NM domain-like protein.	0.641
A0A316UGY4	A0A316UXH1	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	4-aminobutyrate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.453
A0A316UGY4	A0A316UXK1	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein.	0.931
A0A316UGY4	A0A316UYZ7	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	APH-domain-containing protein.	0.590
A0A316UGY4	A0A316UZK2	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Methylmalonate-semialdehyde dehydrogenase.	0.792