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AKV59740.1 AKV59740.1 AKV57920.1 AKV57920.1 AKV58013.1 AKV58013.1 AKV58038.1 AKV58038.1 AKV58091.1 AKV58091.1 ilvA ilvA AKV58281.1 AKV58281.1 metK metK leuD leuD leuC leuC leuB leuB ilvC ilvC AKV58526.1 AKV58526.1 AKV58527.1 AKV58527.1 ilvD ilvD thrB thrB AKV58585.1 AKV58585.1 AKV59021.1 AKV59021.1 metXA metXA AKV59121.1 AKV59121.1 leuA leuA AKV59374.1 AKV59374.1 AKV59981.1 AKV59981.1 AKV59570.1 AKV59570.1 cysS cysS AKV59726.1 AKV59726.1 AKV59727.1 AKV59727.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKV59740.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
AKV57920.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
AKV58013.1Threonine synthase; Catalyzes the formation of L-threonine from O-phospho-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (492 aa)
AKV58038.1Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. (366 aa)
AKV58091.1Methionine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (424 aa)
AKV58281.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (466 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (412 aa)
leuDIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa)
leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (477 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (338 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
AKV58526.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (175 aa)
AKV58527.1Acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (624 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (612 aa)
thrBSerine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (307 aa)
AKV58585.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (447 aa)
AKV59021.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
metXAHomoserine acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (378 aa)
AKV59121.15-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the vitamin-B12 independent methionine synthase family. (534 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (609 aa)
AKV59374.15-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (750 aa)
AKV59981.1Methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (329 aa)
AKV59570.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
cysScysteinyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (450 aa)
AKV59726.1Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)
AKV59727.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (313 aa)
Your Current Organism:
Corynebacterium riegelii
NCBI taxonomy Id: 156976
Other names: ATCC 700782, C. riegelii, CCUG 38180, CIP 105310, DMMZ 2415, DSM 44326, JCM 10389
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